RPS6KA3

 

Full name: ribosomal protein S6 kinase A3 Alias Symbol: RSK2|HU-3
Type: protein-coding gene Cytoband: Xp22.12
Entrez ID: 6197 HGNC ID: HGNC:10432 Ensembl Gene: ENSG00000177189 OMIM ID: 300075
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

RPS6KA3 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04114Oocyte meiosis
hsa04150mTOR signaling pathway
hsa04720Long-term potentiation
hsa04722Neurotrophin signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04931Insulin resistance

 

Expression of RPS6KA3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RPS6KA3 6197 226335_at -0.0576 0.9394
GSE20347 RPS6KA3 6197 203843_at 0.2315 0.3119
GSE23400 RPS6KA3 6197 203843_at 0.2196 0.0007
GSE26886 RPS6KA3 6197 226335_at -0.1399 0.6045
GSE29001 RPS6KA3 6197 203843_at 0.1172 0.7471
GSE38129 RPS6KA3 6197 203843_at 0.2207 0.1934
GSE45670 RPS6KA3 6197 226335_at -0.2493 0.2362
GSE53622 RPS6KA3 6197 100941 -0.5193 0.0000
GSE53624 RPS6KA3 6197 100941 -0.3693 0.0000
GSE63941 RPS6KA3 6197 203843_at 0.4170 0.4109
GSE77861 RPS6KA3 6197 226335_at 0.4747 0.1076
GSE97050 RPS6KA3 6197 A_23_P417331 0.1013 0.6396
SRP007169 RPS6KA3 6197 RNAseq 0.5082 0.1256
SRP008496 RPS6KA3 6197 RNAseq 0.5275 0.0222
SRP064894 RPS6KA3 6197 RNAseq -0.1904 0.4578
SRP133303 RPS6KA3 6197 RNAseq 0.3892 0.1625
SRP159526 RPS6KA3 6197 RNAseq -0.0836 0.8245
SRP193095 RPS6KA3 6197 RNAseq -0.1809 0.1335
SRP219564 RPS6KA3 6197 RNAseq -0.0243 0.9494
TCGA RPS6KA3 6197 RNAseq -0.0268 0.5712

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by RPS6KA3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RPS6KA3:

 

No record found for this gene.

 

Somatic mutations of RPS6KA3:

 

Generating mutation plots.

 

Highly correlated genes for RPS6KA3:

 

Showing top 20/352 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RPS6KA3FMR10.853717303
RPS6KA3ASH2L0.828048303
RPS6KA3SPPL2A0.819064303
RPS6KA3C6orf1200.812768303
RPS6KA3ERI20.775998303
RPS6KA3MIEN10.763092303
RPS6KA3KANSL20.752877303
RPS6KA3HAUS60.748517303
RPS6KA3ANKIB10.746652303
RPS6KA3EZH20.744702404
RPS6KA3ELOF10.742857303
RPS6KA3MRPS330.738088504
RPS6KA3ATXN7L3B0.728345303
RPS6KA3TRMT61B0.724624303
RPS6KA3CASC40.723793303
RPS6KA3SPTBN10.723002303
RPS6KA3GCSH0.721962303
RPS6KA3DDX230.708675303
RPS6KA3PSMD10.704625404
RPS6KA3SNAP230.70457303

For details and further investigation, click here