KIF11

 

Full name: kinesin family member 11 Alias Symbol: Eg5|HKSP|TRIP5
Type: protein-coding gene Cytoband: 10q23.33
Entrez ID: 3832 HGNC ID: HGNC:6388 Ensembl Gene: ENSG00000138160 OMIM ID: 148760
Drug and gene relationship at DGIdb

 

Expression of KIF11:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 KIF11 3832 204444_at 0.9715 0.3100
GSE20347 KIF11 3832 204444_at 0.8762 0.0025
GSE23400 KIF11 3832 204444_at 1.1993 0.0000
GSE26886 KIF11 3832 204444_at -0.1376 0.6580
GSE29001 KIF11 3832 204444_at 1.1431 0.0051
GSE38129 KIF11 3832 204444_at 1.5521 0.0000
GSE45670 KIF11 3832 204444_at 0.8051 0.0003
GSE53622 KIF11 3832 25267 0.8083 0.0000
GSE53624 KIF11 3832 25267 0.9684 0.0000
GSE63941 KIF11 3832 204444_at 2.3756 0.0004
GSE77861 KIF11 3832 204444_at 0.8326 0.1903
GSE97050 KIF11 3832 A_24_P227091 1.6250 0.1453
SRP007169 KIF11 3832 RNAseq 1.3111 0.0083
SRP008496 KIF11 3832 RNAseq 1.1296 0.0004
SRP064894 KIF11 3832 RNAseq 0.7326 0.0127
SRP133303 KIF11 3832 RNAseq 1.0987 0.0001
SRP159526 KIF11 3832 RNAseq 0.8694 0.0035
SRP193095 KIF11 3832 RNAseq 0.6359 0.0000
SRP219564 KIF11 3832 RNAseq 0.7868 0.2491
TCGA KIF11 3832 RNAseq 0.9204 0.0000

Upregulated datasets: 7; Downregulated datasets: 0.  

 

Survival by KIF11 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of KIF11:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 KIF11 3832 2 7 21
GSE20123 KIF11 3832 2 6 22
GSE43470 KIF11 3832 0 8 35
GSE46452 KIF11 3832 0 11 48
GSE47630 KIF11 3832 2 14 24
GSE54993 KIF11 3832 7 0 63
GSE54994 KIF11 3832 1 10 42
GSE60625 KIF11 3832 0 0 11
GSE74703 KIF11 3832 0 6 30
GSE74704 KIF11 3832 0 4 16
TCGA KIF11 3832 7 26 63

Total number of gains: 21; Total number of losses: 92; Total Number of normals: 375.  

 

Somatic mutations of KIF11:

 

Generating mutation plots.

 

Highly correlated genes for KIF11:

 

Showing top 20/1244 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
KIF11CDK10.85385112012
KIF11CEP550.84445813013
KIF11NUSAP10.83043813013
KIF11KIF150.8194712012
KIF11MKI670.8180413013
KIF11BUB1B0.8173981009
KIF11ASPM0.81164213013
KIF11NEK20.80258513013
KIF11PBK0.80226813013
KIF11DNAJC90.79599910010
KIF11PRC10.79424313013
KIF11ZWINT0.79118712012
KIF11MELK0.78966113013
KIF11CCNA20.785713012
KIF11CCNB20.78294512011
KIF11CENPF0.77901113011
KIF11RACGAP10.77827311010
KIF11KIF20B0.77532813012
KIF11DTL0.77476513012
KIF11GMNN0.77335512012

For details and further investigation, click here