| Full name: mitochondrial pyruvate carrier 1 | Alias Symbol: dJ68L15.3|CGI-129|SLC54A1 | ||
| Type: protein-coding gene | Cytoband: 6q27 | ||
| Entrez ID: 51660 | HGNC ID: HGNC:21606 | Ensembl Gene: ENSG00000060762 | OMIM ID: 614738 |
| Drug and gene relationship at DGIdb | |||
Expression of MPC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MPC1 | 51660 | 218024_at | -0.8483 | 0.0474 | |
| GSE20347 | MPC1 | 51660 | 218024_at | -1.1626 | 0.0000 | |
| GSE23400 | MPC1 | 51660 | 218024_at | -0.7334 | 0.0000 | |
| GSE26886 | MPC1 | 51660 | 218024_at | -1.0882 | 0.0000 | |
| GSE29001 | MPC1 | 51660 | 218024_at | -1.2404 | 0.0000 | |
| GSE38129 | MPC1 | 51660 | 218024_at | -1.1507 | 0.0000 | |
| GSE45670 | MPC1 | 51660 | 218024_at | -0.9189 | 0.0000 | |
| GSE53622 | MPC1 | 51660 | 22753 | -1.4898 | 0.0000 | |
| GSE53624 | MPC1 | 51660 | 22753 | -1.3683 | 0.0000 | |
| GSE63941 | MPC1 | 51660 | 218024_at | -0.6423 | 0.2852 | |
| GSE77861 | MPC1 | 51660 | 218024_at | -1.4937 | 0.0017 | |
| SRP007169 | MPC1 | 51660 | RNAseq | -2.3144 | 0.0000 | |
| SRP008496 | MPC1 | 51660 | RNAseq | -2.2836 | 0.0000 | |
| SRP064894 | MPC1 | 51660 | RNAseq | -1.2280 | 0.0000 | |
| SRP133303 | MPC1 | 51660 | RNAseq | -0.6030 | 0.0007 | |
| SRP159526 | MPC1 | 51660 | RNAseq | -0.8124 | 0.0291 | |
| SRP193095 | MPC1 | 51660 | RNAseq | -1.5217 | 0.0000 | |
| SRP219564 | MPC1 | 51660 | RNAseq | -0.7315 | 0.0033 |
Upregulated datasets: 0; Downregulated datasets: 11.
Survival by MPC1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of MPC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MPC1 | 51660 | 2 | 6 | 22 | |
| GSE20123 | MPC1 | 51660 | 2 | 6 | 22 | |
| GSE43470 | MPC1 | 51660 | 3 | 0 | 40 | |
| GSE46452 | MPC1 | 51660 | 3 | 10 | 46 | |
| GSE47630 | MPC1 | 51660 | 7 | 7 | 26 | |
| GSE54993 | MPC1 | 51660 | 4 | 3 | 63 | |
| GSE54994 | MPC1 | 51660 | 9 | 8 | 36 | |
| GSE60625 | MPC1 | 51660 | 1 | 1 | 9 | |
| GSE74703 | MPC1 | 51660 | 3 | 0 | 33 | |
| GSE74704 | MPC1 | 51660 | 1 | 3 | 16 | |
| TCGA | MPC1 | 51660 | 14 | 21 | 61 |
Total number of gains: 49; Total number of losses: 65; Total Number of normals: 374.
Somatic mutations of MPC1:
Generating mutation plots.
Highly correlated genes for MPC1:
Showing top 20/1773 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MPC1 | GPD1L | 0.848966 | 10 | 0 | 10 |
| MPC1 | HPGD | 0.82839 | 10 | 0 | 10 |
| MPC1 | SNORA68 | 0.826804 | 4 | 0 | 4 |
| MPC1 | SH3BGRL2 | 0.826542 | 6 | 0 | 6 |
| MPC1 | SMIM14 | 0.822077 | 5 | 0 | 5 |
| MPC1 | SMDT1 | 0.812915 | 4 | 0 | 4 |
| MPC1 | EIF4E3 | 0.806836 | 6 | 0 | 6 |
| MPC1 | UBL3 | 0.806721 | 10 | 0 | 10 |
| MPC1 | GBP6 | 0.806114 | 4 | 0 | 4 |
| MPC1 | NUCB2 | 0.802342 | 10 | 0 | 10 |
| MPC1 | ETFDH | 0.793605 | 10 | 0 | 10 |
| MPC1 | FAM3D | 0.791081 | 6 | 0 | 6 |
| MPC1 | FAM214A | 0.790668 | 6 | 0 | 6 |
| MPC1 | FAM3B | 0.787305 | 6 | 0 | 6 |
| MPC1 | SUCLG2 | 0.78454 | 10 | 0 | 10 |
| MPC1 | KAT2B | 0.776913 | 11 | 0 | 10 |
| MPC1 | C5orf66-AS1 | 0.775183 | 6 | 0 | 6 |
| MPC1 | CAB39L | 0.773574 | 10 | 0 | 10 |
| MPC1 | LMBRD1 | 0.773542 | 11 | 0 | 10 |
| MPC1 | HSD17B4 | 0.771581 | 9 | 0 | 9 |
For details and further investigation, click here
