CCNE1

 

Full name: cyclin E1 Alias Symbol: 
Type: protein-coding gene Cytoband: 19q12
Entrez ID: 898 HGNC ID: HGNC:1589 Ensembl Gene: ENSG00000105173 OMIM ID: 123837
Drug and gene relationship at DGIdb
Screen Evidence:

 

CCNE1 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle
hsa04114Oocyte meiosis
hsa04115p53 signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa05162Measles
hsa05200Pathways in cancer
hsa05215Prostate cancer
hsa05222Small cell lung cancer

 

Expression of CCNE1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CCNE1 898 213523_at 1.5640 0.0186
GSE20347 CCNE1 898 213523_at 0.7258 0.0002
GSE23400 CCNE1 898 213523_at 0.3971 0.0001
GSE26886 CCNE1 898 213523_at 0.5445 0.0109
GSE29001 CCNE1 898 213523_at 1.0519 0.0022
GSE38129 CCNE1 898 213523_at 0.9035 0.0000
GSE45670 CCNE1 898 213523_at 1.0885 0.0002
GSE53622 CCNE1 898 57509 0.6861 0.0000
GSE53624 CCNE1 898 57509 1.0744 0.0000
GSE63941 CCNE1 898 213523_at -0.1794 0.8320
GSE77861 CCNE1 898 213523_at 0.5361 0.1287
GSE97050 CCNE1 898 A_23_P209200 0.5359 0.2416
SRP007169 CCNE1 898 RNAseq 0.0462 0.9408
SRP008496 CCNE1 898 RNAseq 0.1649 0.6709
SRP064894 CCNE1 898 RNAseq 1.0269 0.0010
SRP133303 CCNE1 898 RNAseq 1.0235 0.0004
SRP159526 CCNE1 898 RNAseq 1.4267 0.0010
SRP193095 CCNE1 898 RNAseq 0.6228 0.0001
SRP219564 CCNE1 898 RNAseq 0.5612 0.3241
TCGA CCNE1 898 RNAseq 0.8392 0.0000

Upregulated datasets: 7; Downregulated datasets: 0.  

 

Survival by CCNE1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CCNE1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CCNE1 898 6 7 17
GSE20123 CCNE1 898 6 6 18
GSE43470 CCNE1 898 6 6 31
GSE46452 CCNE1 898 47 1 11
GSE47630 CCNE1 898 8 6 26
GSE54993 CCNE1 898 17 3 50
GSE54994 CCNE1 898 7 11 35
GSE60625 CCNE1 898 9 0 2
GSE74703 CCNE1 898 6 4 26
GSE74704 CCNE1 898 5 4 11
TCGA CCNE1 898 18 12 66

Total number of gains: 135; Total number of losses: 60; Total Number of normals: 293.  

 

Somatic mutations of CCNE1:

 

Generating mutation plots.

 

Highly correlated genes for CCNE1:

 

Showing top 20/1437 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CCNE1CDCA20.788169303
CCNE1DHX330.757204404
CCNE1GORAB0.743547403
CCNE1UBQLN40.740848404
CCNE1DOCK60.736826404
CCNE1WIPI10.736807303
CCNE1UBE2T0.727502505
CCNE1DSCC10.722523605
CCNE1STX160.719468303
CCNE1LRRC580.718864403
CCNE1FABP40.714741303
CCNE1ZFYVE270.710121303
CCNE1ZNF8300.703687303
CCNE1EXOC80.700518303
CCNE1MRPL140.699833504
CCNE1DHX370.69824606
CCNE1F2RL10.69716303
CCNE1ZAP700.696679303
CCNE1MAGOHB0.693816605
CCNE1NACC10.692607605

For details and further investigation, click here