| Full name: chromosome 21 open reading frame 58 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 21q22.3 | ||
| Entrez ID: 54058 | HGNC ID: HGNC:1300 | Ensembl Gene: ENSG00000160298 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of C21orf58:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | C21orf58 | 54058 | 238541_at | 0.4399 | 0.2006 | |
| GSE26886 | C21orf58 | 54058 | 238541_at | 0.2897 | 0.0610 | |
| GSE45670 | C21orf58 | 54058 | 1555198_x_at | -0.0247 | 0.7689 | |
| GSE53622 | C21orf58 | 54058 | 112057 | 0.4611 | 0.0000 | |
| GSE53624 | C21orf58 | 54058 | 112057 | 0.3085 | 0.0081 | |
| GSE63941 | C21orf58 | 54058 | 238541_at | 0.6596 | 0.0145 | |
| GSE77861 | C21orf58 | 54058 | 1559438_at | -0.0709 | 0.6736 | |
| GSE97050 | C21orf58 | 54058 | A_23_P132139 | 0.2572 | 0.3948 | |
| SRP007169 | C21orf58 | 54058 | RNAseq | 0.2417 | 0.6561 | |
| SRP008496 | C21orf58 | 54058 | RNAseq | 0.1299 | 0.7256 | |
| SRP064894 | C21orf58 | 54058 | RNAseq | 1.3897 | 0.0001 | |
| SRP133303 | C21orf58 | 54058 | RNAseq | 0.2820 | 0.1923 | |
| SRP159526 | C21orf58 | 54058 | RNAseq | 1.1506 | 0.0061 | |
| SRP193095 | C21orf58 | 54058 | RNAseq | 0.5885 | 0.0001 | |
| SRP219564 | C21orf58 | 54058 | RNAseq | 0.5423 | 0.3497 | |
| TCGA | C21orf58 | 54058 | RNAseq | 0.7491 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by C21orf58 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of C21orf58:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | C21orf58 | 54058 | 3 | 9 | 18 | |
| GSE20123 | C21orf58 | 54058 | 3 | 9 | 18 | |
| GSE43470 | C21orf58 | 54058 | 0 | 14 | 29 | |
| GSE46452 | C21orf58 | 54058 | 1 | 21 | 37 | |
| GSE47630 | C21orf58 | 54058 | 6 | 17 | 17 | |
| GSE54993 | C21orf58 | 54058 | 8 | 1 | 61 | |
| GSE54994 | C21orf58 | 54058 | 5 | 8 | 40 | |
| GSE60625 | C21orf58 | 54058 | 0 | 0 | 11 | |
| GSE74703 | C21orf58 | 54058 | 0 | 10 | 26 | |
| GSE74704 | C21orf58 | 54058 | 1 | 5 | 14 | |
| TCGA | C21orf58 | 54058 | 10 | 37 | 49 |
Total number of gains: 37; Total number of losses: 131; Total Number of normals: 320.
Somatic mutations of C21orf58:
Generating mutation plots.
Highly correlated genes for C21orf58:
Showing top 20/397 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| C21orf58 | FASN | 0.748027 | 3 | 0 | 3 |
| C21orf58 | CBS | 0.745609 | 3 | 0 | 3 |
| C21orf58 | SLC32A1 | 0.720222 | 3 | 0 | 3 |
| C21orf58 | TYK2 | 0.716685 | 4 | 0 | 3 |
| C21orf58 | MBD4 | 0.713148 | 4 | 0 | 4 |
| C21orf58 | GRINA | 0.709597 | 3 | 0 | 3 |
| C21orf58 | PNPT1 | 0.704692 | 3 | 0 | 3 |
| C21orf58 | SRSF10 | 0.704253 | 3 | 0 | 3 |
| C21orf58 | OR2T12 | 0.699045 | 3 | 0 | 3 |
| C21orf58 | ZFP41 | 0.698747 | 3 | 0 | 3 |
| C21orf58 | CDC25A | 0.698145 | 4 | 0 | 4 |
| C21orf58 | GORAB | 0.695892 | 3 | 0 | 3 |
| C21orf58 | CYHR1 | 0.693589 | 4 | 0 | 3 |
| C21orf58 | MAP2K2 | 0.691352 | 3 | 0 | 3 |
| C21orf58 | SNAPC4 | 0.682313 | 3 | 0 | 3 |
| C21orf58 | PPP6R1 | 0.681813 | 4 | 0 | 3 |
| C21orf58 | DNMT1 | 0.681799 | 5 | 0 | 4 |
| C21orf58 | RAVER1 | 0.676447 | 5 | 0 | 5 |
| C21orf58 | SPPL2B | 0.675979 | 4 | 0 | 4 |
| C21orf58 | DNAJB11 | 0.675657 | 3 | 0 | 3 |
For details and further investigation, click here
