FAT1

 

Full name: FAT atypical cadherin 1 Alias Symbol: CDHF7|CDHR8
Type: protein-coding gene Cytoband: 4q35.2
Entrez ID: 2195 HGNC ID: HGNC:3595 Ensembl Gene: ENSG00000083857 OMIM ID: 600976
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of FAT1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FAT1 2195 201579_at 1.0670 0.0538
GSE20347 FAT1 2195 201579_at 1.2403 0.0000
GSE23400 FAT1 2195 201579_at 1.3979 0.0000
GSE26886 FAT1 2195 201579_at 2.1969 0.0001
GSE29001 FAT1 2195 201579_at 0.8153 0.1693
GSE38129 FAT1 2195 201579_at 1.2034 0.0000
GSE45670 FAT1 2195 201579_at 0.8806 0.0036
GSE53622 FAT1 2195 94961 0.7619 0.0000
GSE53624 FAT1 2195 94961 -0.0383 0.6669
GSE63941 FAT1 2195 201579_at -1.8020 0.0883
GSE77861 FAT1 2195 201579_at 1.9906 0.0030
GSE97050 FAT1 2195 A_23_P69586 0.7813 0.0938
SRP007169 FAT1 2195 RNAseq 2.6213 0.0000
SRP008496 FAT1 2195 RNAseq 2.4558 0.0000
SRP064894 FAT1 2195 RNAseq 1.1682 0.0019
SRP133303 FAT1 2195 RNAseq 1.6200 0.0000
SRP159526 FAT1 2195 RNAseq 1.3443 0.0278
SRP193095 FAT1 2195 RNAseq 1.3759 0.0000
SRP219564 FAT1 2195 RNAseq 1.1256 0.0367
TCGA FAT1 2195 RNAseq 0.1261 0.1040

Upregulated datasets: 12; Downregulated datasets: 0.  

 

Survival by FAT1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FAT1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FAT1 2195 2 12 16
GSE20123 FAT1 2195 2 12 16
GSE43470 FAT1 2195 1 15 27
GSE46452 FAT1 2195 1 36 22
GSE47630 FAT1 2195 0 22 18
GSE54993 FAT1 2195 10 0 60
GSE54994 FAT1 2195 2 14 37
GSE60625 FAT1 2195 1 0 10
GSE74703 FAT1 2195 1 12 23
GSE74704 FAT1 2195 0 6 14
TCGA FAT1 2195 10 35 51

Total number of gains: 30; Total number of losses: 164; Total Number of normals: 294.  

 

Somatic mutations of FAT1:

 

Generating mutation plots.

 

Highly correlated genes for FAT1:

 

Showing top 20/1449 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FAT1WDR810.779838303
FAT1KLHL130.775337303
FAT1KLF130.741189303
FAT1RILPL10.737253303
FAT1ATP11C0.734962404
FAT1WDR660.732866505
FAT1KCTD130.732318303
FAT1ACBD60.71439404
FAT1PLAU0.70958909
FAT1PHF5A0.70915404
FAT1FMNL20.707742707
FAT1FNDC3B0.7068631008
FAT1MBOAT70.702284303
FAT1ITGAV0.7004751009
FAT1THEM40.696964303
FAT1CCM20.694864505
FAT1TBL1XR10.694715707
FAT1LPCAT10.6935181009
FAT1ALKBH60.690851403
FAT1FUCA20.685805403

For details and further investigation, click here