PLAU

 

Full name: plasminogen activator, urokinase Alias Symbol: URK|UPA
Type: protein-coding gene Cytoband: 10q22.2
Entrez ID: 5328 HGNC ID: HGNC:9052 Ensembl Gene: ENSG00000122861 OMIM ID: 191840
Drug and gene relationship at DGIdb

 

PLAU involved pathways:

KEGG pathway Description View
hsa04064NF-kappa B signaling pathway
hsa04610Complement and coagulation cascades
hsa05205Proteoglycans in cancer

 

Expression of PLAU:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PLAU 5328 205479_s_at 2.5771 0.0036
GSE20347 PLAU 5328 205479_s_at 2.2848 0.0000
GSE23400 PLAU 5328 205479_s_at 2.1484 0.0000
GSE26886 PLAU 5328 205479_s_at 2.5508 0.0000
GSE29001 PLAU 5328 205479_s_at 2.6500 0.0000
GSE38129 PLAU 5328 205479_s_at 2.5034 0.0000
GSE45670 PLAU 5328 205479_s_at 2.1105 0.0004
GSE53622 PLAU 5328 5078 2.3236 0.0000
GSE53624 PLAU 5328 5078 2.5992 0.0000
GSE63941 PLAU 5328 205479_s_at -0.8794 0.6434
GSE77861 PLAU 5328 205479_s_at 1.6047 0.0130
GSE97050 PLAU 5328 A_23_P24104 1.3727 0.0981
SRP007169 PLAU 5328 RNAseq 3.5436 0.0000
SRP008496 PLAU 5328 RNAseq 3.8302 0.0000
SRP064894 PLAU 5328 RNAseq 2.8848 0.0000
SRP133303 PLAU 5328 RNAseq 3.3961 0.0000
SRP159526 PLAU 5328 RNAseq 2.2075 0.0000
SRP193095 PLAU 5328 RNAseq 3.5505 0.0000
SRP219564 PLAU 5328 RNAseq 2.6901 0.0000
TCGA PLAU 5328 RNAseq 0.9749 0.0000

Upregulated datasets: 17; Downregulated datasets: 0.  


 

Survival by PLAU expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of PLAU:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PLAU 5328 3 4 23
GSE20123 PLAU 5328 3 3 24
GSE43470 PLAU 5328 1 8 34
GSE46452 PLAU 5328 0 11 48
GSE47630 PLAU 5328 2 14 24
GSE54993 PLAU 5328 7 0 63
GSE54994 PLAU 5328 2 10 41
GSE60625 PLAU 5328 0 0 11
GSE74703 PLAU 5328 1 5 30
GSE74704 PLAU 5328 1 1 18
TCGA PLAU 5328 10 23 63

Total number of gains: 30; Total number of losses: 79; Total Number of normals: 379.  


 

Somatic mutations of PLAU:

 

Generating mutation plots.

 

Highly correlated genes for PLAU:

 

Showing top 20/2165 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PLAULAMC20.83538312012
PLAUXPR10.831068707
PLAUCOLGALT10.82053610010
PLAUCTHRC10.818856707
PLAUFNDC3B0.80474311011
PLAUMFAP20.80229212011
PLAULAMB30.79898512012
PLAUDNMT10.79729811011
PLAUMMP10.7943213012
PLAUCEP550.792910010
PLAUWDR660.791873707
PLAUCKS1B0.79079811011
PLAUAGRN0.78792311011
PLAUCBX30.7864410010
PLAUFMNL20.785893707
PLAUADAMTS120.783752707
PLAUCOL5A10.78174111011
PLAUITPR30.77847411011
PLAUCDH30.77695810010
PLAUITGA60.77669312011

For details and further investigation, click here