| Full name: plasminogen activator, urokinase | Alias Symbol: URK|UPA | ||
| Type: protein-coding gene | Cytoband: 10q22.2 | ||
| Entrez ID: 5328 | HGNC ID: HGNC:9052 | Ensembl Gene: ENSG00000122861 | OMIM ID: 191840 |
| Drug and gene relationship at DGIdb | |||
PLAU involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04064 | NF-kappa B signaling pathway | |
| hsa04610 | Complement and coagulation cascades | |
| hsa05205 | Proteoglycans in cancer |
Expression of PLAU:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLAU | 5328 | 205479_s_at | 2.5771 | 0.0036 | |
| GSE20347 | PLAU | 5328 | 205479_s_at | 2.2848 | 0.0000 | |
| GSE23400 | PLAU | 5328 | 205479_s_at | 2.1484 | 0.0000 | |
| GSE26886 | PLAU | 5328 | 205479_s_at | 2.5508 | 0.0000 | |
| GSE29001 | PLAU | 5328 | 205479_s_at | 2.6500 | 0.0000 | |
| GSE38129 | PLAU | 5328 | 205479_s_at | 2.5034 | 0.0000 | |
| GSE45670 | PLAU | 5328 | 205479_s_at | 2.1105 | 0.0004 | |
| GSE53622 | PLAU | 5328 | 5078 | 2.3236 | 0.0000 | |
| GSE53624 | PLAU | 5328 | 5078 | 2.5992 | 0.0000 | |
| GSE63941 | PLAU | 5328 | 205479_s_at | -0.8794 | 0.6434 | |
| GSE77861 | PLAU | 5328 | 205479_s_at | 1.6047 | 0.0130 | |
| GSE97050 | PLAU | 5328 | A_23_P24104 | 1.3727 | 0.0981 | |
| SRP007169 | PLAU | 5328 | RNAseq | 3.5436 | 0.0000 | |
| SRP008496 | PLAU | 5328 | RNAseq | 3.8302 | 0.0000 | |
| SRP064894 | PLAU | 5328 | RNAseq | 2.8848 | 0.0000 | |
| SRP133303 | PLAU | 5328 | RNAseq | 3.3961 | 0.0000 | |
| SRP159526 | PLAU | 5328 | RNAseq | 2.2075 | 0.0000 | |
| SRP193095 | PLAU | 5328 | RNAseq | 3.5505 | 0.0000 | |
| SRP219564 | PLAU | 5328 | RNAseq | 2.6901 | 0.0000 | |
| TCGA | PLAU | 5328 | RNAseq | 0.9749 | 0.0000 |
Upregulated datasets: 17; Downregulated datasets: 0.
Survival by PLAU expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLAU:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLAU | 5328 | 3 | 4 | 23 | |
| GSE20123 | PLAU | 5328 | 3 | 3 | 24 | |
| GSE43470 | PLAU | 5328 | 1 | 8 | 34 | |
| GSE46452 | PLAU | 5328 | 0 | 11 | 48 | |
| GSE47630 | PLAU | 5328 | 2 | 14 | 24 | |
| GSE54993 | PLAU | 5328 | 7 | 0 | 63 | |
| GSE54994 | PLAU | 5328 | 2 | 10 | 41 | |
| GSE60625 | PLAU | 5328 | 0 | 0 | 11 | |
| GSE74703 | PLAU | 5328 | 1 | 5 | 30 | |
| GSE74704 | PLAU | 5328 | 1 | 1 | 18 | |
| TCGA | PLAU | 5328 | 10 | 23 | 63 |
Total number of gains: 30; Total number of losses: 79; Total Number of normals: 379.
Somatic mutations of PLAU:
Generating mutation plots.
Highly correlated genes for PLAU:
Showing top 20/2165 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLAU | LAMC2 | 0.835383 | 12 | 0 | 12 |
| PLAU | XPR1 | 0.831068 | 7 | 0 | 7 |
| PLAU | COLGALT1 | 0.820536 | 10 | 0 | 10 |
| PLAU | CTHRC1 | 0.818856 | 7 | 0 | 7 |
| PLAU | FNDC3B | 0.804743 | 11 | 0 | 11 |
| PLAU | MFAP2 | 0.802292 | 12 | 0 | 11 |
| PLAU | LAMB3 | 0.798985 | 12 | 0 | 12 |
| PLAU | DNMT1 | 0.797298 | 11 | 0 | 11 |
| PLAU | MMP1 | 0.79432 | 13 | 0 | 12 |
| PLAU | CEP55 | 0.7929 | 10 | 0 | 10 |
| PLAU | WDR66 | 0.791873 | 7 | 0 | 7 |
| PLAU | CKS1B | 0.790798 | 11 | 0 | 11 |
| PLAU | AGRN | 0.787923 | 11 | 0 | 11 |
| PLAU | CBX3 | 0.78644 | 10 | 0 | 10 |
| PLAU | FMNL2 | 0.785893 | 7 | 0 | 7 |
| PLAU | ADAMTS12 | 0.783752 | 7 | 0 | 7 |
| PLAU | COL5A1 | 0.781741 | 11 | 0 | 11 |
| PLAU | ITPR3 | 0.778474 | 11 | 0 | 11 |
| PLAU | CDH3 | 0.776958 | 10 | 0 | 10 |
| PLAU | ITGA6 | 0.776693 | 12 | 0 | 11 |
For details and further investigation, click here
