TBL1XR1

 

Full name: transducin beta like 1 X-linked receptor 1 Alias Symbol: IRA1|FLJ12894|TBLR1|C21|DC42
Type: protein-coding gene Cytoband: 3q26.32
Entrez ID: 79718 HGNC ID: HGNC:29529 Ensembl Gene: ENSG00000177565 OMIM ID: 608628
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 81/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

TBL1XR1 involved pathways:

KEGG pathway Description View
hsa04310Wnt signaling pathway

 

Expression of TBL1XR1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TBL1XR1 79718 223013_at 0.8684 0.0822
GSE20347 TBL1XR1 79718 221428_s_at 1.1847 0.0001
GSE23400 TBL1XR1 79718 221428_s_at 1.2113 0.0000
GSE26886 TBL1XR1 79718 223013_at 0.9364 0.0001
GSE29001 TBL1XR1 79718 221428_s_at 1.0942 0.0582
GSE38129 TBL1XR1 79718 221428_s_at 1.4923 0.0000
GSE45670 TBL1XR1 79718 223013_at 0.5702 0.0095
GSE53622 TBL1XR1 79718 19881 0.8543 0.0000
GSE53624 TBL1XR1 79718 19881 0.7586 0.0000
GSE63941 TBL1XR1 79718 223013_at 0.1273 0.8576
GSE77861 TBL1XR1 79718 223013_at 0.9965 0.0086
GSE97050 TBL1XR1 79718 A_33_P3348614 0.5212 0.1455
SRP007169 TBL1XR1 79718 RNAseq 1.1674 0.0056
SRP008496 TBL1XR1 79718 RNAseq 1.3501 0.0000
SRP064894 TBL1XR1 79718 RNAseq 0.9113 0.0000
SRP133303 TBL1XR1 79718 RNAseq 1.4739 0.0000
SRP159526 TBL1XR1 79718 RNAseq 1.4540 0.0002
SRP193095 TBL1XR1 79718 RNAseq 0.7740 0.0000
SRP219564 TBL1XR1 79718 RNAseq 0.5544 0.2521
TCGA TBL1XR1 79718 RNAseq 0.2624 0.0000

Upregulated datasets: 7; Downregulated datasets: 0.  

 

Survival by TBL1XR1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TBL1XR1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TBL1XR1 79718 24 0 6
GSE20123 TBL1XR1 79718 24 0 6
GSE43470 TBL1XR1 79718 24 0 19
GSE46452 TBL1XR1 79718 19 1 39
GSE47630 TBL1XR1 79718 27 2 11
GSE54993 TBL1XR1 79718 1 18 51
GSE54994 TBL1XR1 79718 41 0 12
GSE60625 TBL1XR1 79718 0 6 5
GSE74703 TBL1XR1 79718 20 0 16
GSE74704 TBL1XR1 79718 16 0 4
TCGA TBL1XR1 79718 78 0 18

Total number of gains: 274; Total number of losses: 27; Total Number of normals: 187.  

 

Somatic mutations of TBL1XR1:

 

Generating mutation plots.

 

Highly correlated genes for TBL1XR1:

 

Showing top 20/1939 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TBL1XR1ACTL6A0.76405113012
TBL1XR1GHDC0.762115303
TBL1XR1RWDD2A0.74342303
TBL1XR1PPT10.73430311011
TBL1XR1RFC40.73268512011
TBL1XR1AURKAIP10.732317303
TBL1XR1TRIM590.731143504
TBL1XR1MRPL470.729581908
TBL1XR1LRRC580.724808606
TBL1XR1POLRMT0.721947303
TBL1XR1DGUOK0.72113611010
TBL1XR1ALKBH60.720816404
TBL1XR1HPS30.719045605
TBL1XR1LSM100.717645404
TBL1XR1HLTF0.71632812011
TBL1XR1FXR10.7157191109
TBL1XR1DESI20.715193909
TBL1XR1PSMD20.71350212011
TBL1XR1TOPBP10.711612011
TBL1XR1HMCES0.709743909

For details and further investigation, click here