| Full name: FAT atypical cadherin 3 | Alias Symbol: KIAA1989|CDHF15|CDHR10 | ||
| Type: protein-coding gene | Cytoband: 11q14.3 | ||
| Entrez ID: 120114 | HGNC ID: HGNC:23112 | Ensembl Gene: ENSG00000165323 | OMIM ID: 612483 |
| Drug and gene relationship at DGIdb | |||
Expression of FAT3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FAT3 | 120114 | 236029_at | -0.8858 | 0.6166 | |
| GSE26886 | FAT3 | 120114 | 236029_at | 0.4570 | 0.2402 | |
| GSE45670 | FAT3 | 120114 | 236029_at | -1.1118 | 0.0153 | |
| GSE53622 | FAT3 | 120114 | 89440 | -0.0377 | 0.9027 | |
| GSE53624 | FAT3 | 120114 | 89440 | 0.5515 | 0.0036 | |
| GSE63941 | FAT3 | 120114 | 236029_at | -2.6238 | 0.0058 | |
| GSE77861 | FAT3 | 120114 | 236029_at | -0.0888 | 0.5023 | |
| GSE97050 | FAT3 | 120114 | A_33_P3257513 | 0.2928 | 0.3309 | |
| SRP007169 | FAT3 | 120114 | RNAseq | 2.3964 | 0.0010 | |
| SRP133303 | FAT3 | 120114 | RNAseq | -0.3885 | 0.4638 | |
| SRP159526 | FAT3 | 120114 | RNAseq | -0.4908 | 0.4835 | |
| SRP193095 | FAT3 | 120114 | RNAseq | 0.0135 | 0.9718 | |
| TCGA | FAT3 | 120114 | RNAseq | -0.8379 | 0.0278 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by FAT3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FAT3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FAT3 | 120114 | 3 | 10 | 17 | |
| GSE20123 | FAT3 | 120114 | 3 | 10 | 17 | |
| GSE43470 | FAT3 | 120114 | 2 | 5 | 36 | |
| GSE46452 | FAT3 | 120114 | 5 | 24 | 30 | |
| GSE47630 | FAT3 | 120114 | 2 | 19 | 19 | |
| GSE54993 | FAT3 | 120114 | 8 | 2 | 60 | |
| GSE54994 | FAT3 | 120114 | 5 | 19 | 29 | |
| GSE60625 | FAT3 | 120114 | 0 | 3 | 8 | |
| GSE74703 | FAT3 | 120114 | 1 | 4 | 31 | |
| GSE74704 | FAT3 | 120114 | 3 | 6 | 11 | |
| TCGA | FAT3 | 120114 | 14 | 40 | 42 |
Total number of gains: 46; Total number of losses: 142; Total Number of normals: 300.
Somatic mutations of FAT3:
Generating mutation plots.
Highly correlated genes for FAT3:
Showing top 20/295 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FAT3 | SGCD | 0.749289 | 4 | 0 | 4 |
| FAT3 | MGARP | 0.738602 | 3 | 0 | 3 |
| FAT3 | ENPP6 | 0.717997 | 4 | 0 | 4 |
| FAT3 | PDZRN4 | 0.708612 | 4 | 0 | 3 |
| FAT3 | PDE3A | 0.697619 | 4 | 0 | 3 |
| FAT3 | ZNF471 | 0.689287 | 3 | 0 | 3 |
| FAT3 | CORO2B | 0.688539 | 4 | 0 | 3 |
| FAT3 | CACNA1C | 0.685224 | 5 | 0 | 5 |
| FAT3 | MYOT | 0.684702 | 3 | 0 | 3 |
| FAT3 | SHISA3 | 0.684041 | 5 | 0 | 4 |
| FAT3 | SLC2A13 | 0.67808 | 4 | 0 | 4 |
| FAT3 | SYT11 | 0.671211 | 5 | 0 | 4 |
| FAT3 | RBM7 | 0.662627 | 3 | 0 | 3 |
| FAT3 | ITGBL1 | 0.65686 | 4 | 0 | 4 |
| FAT3 | STAMBPL1 | 0.655804 | 3 | 0 | 3 |
| FAT3 | PIGB | 0.653448 | 3 | 0 | 3 |
| FAT3 | SLC4A4 | 0.652137 | 4 | 0 | 4 |
| FAT3 | JAM2 | 0.649761 | 4 | 0 | 3 |
| FAT3 | PARVA | 0.649708 | 5 | 0 | 4 |
| FAT3 | ARHGEF25 | 0.649417 | 3 | 0 | 3 |
For details and further investigation, click here
