| Full name: ectonucleotide pyrophosphatase/phosphodiesterase 6 | Alias Symbol: MGC33971 | ||
| Type: protein-coding gene | Cytoband: 4q35.1 | ||
| Entrez ID: 133121 | HGNC ID: HGNC:23409 | Ensembl Gene: ENSG00000164303 | OMIM ID: 616983 |
| Drug and gene relationship at DGIdb | |||
Expression of ENPP6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ENPP6 | 133121 | 229916_at | -0.4091 | 0.3687 | |
| GSE26886 | ENPP6 | 133121 | 229916_at | 0.2810 | 0.1516 | |
| GSE45670 | ENPP6 | 133121 | 229916_at | -0.6750 | 0.0015 | |
| GSE53622 | ENPP6 | 133121 | 3088 | -1.5800 | 0.0000 | |
| GSE53624 | ENPP6 | 133121 | 3088 | -2.1122 | 0.0000 | |
| GSE63941 | ENPP6 | 133121 | 229916_at | -0.0341 | 0.8034 | |
| GSE77861 | ENPP6 | 133121 | 229916_at | -0.0244 | 0.7276 | |
| SRP064894 | ENPP6 | 133121 | RNAseq | -0.9104 | 0.0165 | |
| SRP133303 | ENPP6 | 133121 | RNAseq | -0.4275 | 0.0028 | |
| SRP159526 | ENPP6 | 133121 | RNAseq | 0.5643 | 0.3343 | |
| SRP193095 | ENPP6 | 133121 | RNAseq | -0.1829 | 0.2970 | |
| SRP219564 | ENPP6 | 133121 | RNAseq | 0.0087 | 0.9916 | |
| TCGA | ENPP6 | 133121 | RNAseq | -1.4970 | 0.0068 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by ENPP6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ENPP6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ENPP6 | 133121 | 3 | 12 | 15 | |
| GSE20123 | ENPP6 | 133121 | 3 | 12 | 15 | |
| GSE43470 | ENPP6 | 133121 | 1 | 12 | 30 | |
| GSE46452 | ENPP6 | 133121 | 1 | 36 | 22 | |
| GSE47630 | ENPP6 | 133121 | 0 | 22 | 18 | |
| GSE54993 | ENPP6 | 133121 | 10 | 0 | 60 | |
| GSE54994 | ENPP6 | 133121 | 2 | 12 | 39 | |
| GSE60625 | ENPP6 | 133121 | 0 | 0 | 11 | |
| GSE74703 | ENPP6 | 133121 | 1 | 9 | 26 | |
| GSE74704 | ENPP6 | 133121 | 1 | 5 | 14 | |
| TCGA | ENPP6 | 133121 | 11 | 32 | 53 |
Total number of gains: 33; Total number of losses: 152; Total Number of normals: 303.
Somatic mutations of ENPP6:
Generating mutation plots.
Highly correlated genes for ENPP6:
Showing top 20/454 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ENPP6 | SEMA3E | 0.766348 | 4 | 0 | 4 |
| ENPP6 | XKR4 | 0.749054 | 5 | 0 | 5 |
| ENPP6 | RNF150 | 0.73585 | 5 | 0 | 5 |
| ENPP6 | NEGR1 | 0.734159 | 5 | 0 | 5 |
| ENPP6 | PWAR5 | 0.733835 | 3 | 0 | 3 |
| ENPP6 | C1QTNF7 | 0.731841 | 5 | 0 | 4 |
| ENPP6 | PLCXD3 | 0.726712 | 5 | 0 | 5 |
| ENPP6 | PARD3B | 0.724234 | 3 | 0 | 3 |
| ENPP6 | ABCA6 | 0.723988 | 4 | 0 | 4 |
| ENPP6 | CASQ2 | 0.723739 | 4 | 0 | 4 |
| ENPP6 | JAM2 | 0.721619 | 4 | 0 | 4 |
| ENPP6 | NDNF | 0.720366 | 4 | 0 | 4 |
| ENPP6 | ARRB1 | 0.719431 | 4 | 0 | 4 |
| ENPP6 | CBX7 | 0.718019 | 4 | 0 | 4 |
| ENPP6 | FAT3 | 0.717997 | 4 | 0 | 4 |
| ENPP6 | RASL12 | 0.71792 | 4 | 0 | 4 |
| ENPP6 | MYOC | 0.716041 | 4 | 0 | 4 |
| ENPP6 | BBS1 | 0.704363 | 3 | 0 | 3 |
| ENPP6 | SGCA | 0.703895 | 4 | 0 | 3 |
| ENPP6 | PABPC5 | 0.70086 | 4 | 0 | 3 |
For details and further investigation, click here
