| Full name: PDZ domain containing ring finger 4 | Alias Symbol: DKFZp434B0417|LNX4|FLJ33777|IMAGE5767589 | ||
| Type: protein-coding gene | Cytoband: 12q12 | ||
| Entrez ID: 29951 | HGNC ID: HGNC:30552 | Ensembl Gene: ENSG00000165966 | OMIM ID: 609730 |
| Drug and gene relationship at DGIdb | |||
Expression of PDZRN4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDZRN4 | 29951 | 220595_at | -2.1168 | 0.1411 | |
| GSE20347 | PDZRN4 | 29951 | 220595_at | -0.3715 | 0.1716 | |
| GSE23400 | PDZRN4 | 29951 | 220595_at | -0.4580 | 0.0007 | |
| GSE26886 | PDZRN4 | 29951 | 220595_at | -0.0539 | 0.6805 | |
| GSE29001 | PDZRN4 | 29951 | 220595_at | -0.6144 | 0.0033 | |
| GSE38129 | PDZRN4 | 29951 | 220595_at | -1.2457 | 0.0079 | |
| GSE45670 | PDZRN4 | 29951 | 220595_at | -3.3075 | 0.0000 | |
| GSE53622 | PDZRN4 | 29951 | 62342 | -2.4574 | 0.0000 | |
| GSE53624 | PDZRN4 | 29951 | 67064 | -2.4922 | 0.0000 | |
| GSE63941 | PDZRN4 | 29951 | 220595_at | -0.3141 | 0.0161 | |
| GSE77861 | PDZRN4 | 29951 | 220595_at | -0.1025 | 0.2412 | |
| GSE97050 | PDZRN4 | 29951 | A_23_P105651 | -1.6305 | 0.0969 | |
| SRP064894 | PDZRN4 | 29951 | RNAseq | -0.4327 | 0.3902 | |
| SRP133303 | PDZRN4 | 29951 | RNAseq | -1.8433 | 0.0000 | |
| SRP159526 | PDZRN4 | 29951 | RNAseq | -1.4926 | 0.1281 | |
| SRP219564 | PDZRN4 | 29951 | RNAseq | -0.5077 | 0.7241 | |
| TCGA | PDZRN4 | 29951 | RNAseq | -1.4169 | 0.0022 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by PDZRN4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDZRN4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDZRN4 | 29951 | 6 | 1 | 23 | |
| GSE20123 | PDZRN4 | 29951 | 6 | 1 | 23 | |
| GSE43470 | PDZRN4 | 29951 | 4 | 3 | 36 | |
| GSE46452 | PDZRN4 | 29951 | 8 | 1 | 50 | |
| GSE47630 | PDZRN4 | 29951 | 11 | 2 | 27 | |
| GSE54993 | PDZRN4 | 29951 | 0 | 8 | 62 | |
| GSE54994 | PDZRN4 | 29951 | 7 | 1 | 45 | |
| GSE60625 | PDZRN4 | 29951 | 0 | 0 | 11 | |
| GSE74703 | PDZRN4 | 29951 | 4 | 2 | 30 | |
| GSE74704 | PDZRN4 | 29951 | 2 | 1 | 17 | |
| TCGA | PDZRN4 | 29951 | 17 | 12 | 67 |
Total number of gains: 65; Total number of losses: 32; Total Number of normals: 391.
Somatic mutations of PDZRN4:
Generating mutation plots.
Highly correlated genes for PDZRN4:
Showing top 20/1282 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDZRN4 | ATP1A2 | 0.872563 | 9 | 0 | 9 |
| PDZRN4 | CASQ2 | 0.872352 | 9 | 0 | 9 |
| PDZRN4 | TCEAL2 | 0.834904 | 8 | 0 | 8 |
| PDZRN4 | LMOD1 | 0.829625 | 10 | 0 | 10 |
| PDZRN4 | CYP21A2 | 0.823422 | 3 | 0 | 3 |
| PDZRN4 | KCNMB1 | 0.820774 | 9 | 0 | 9 |
| PDZRN4 | NCAM1 | 0.816845 | 9 | 0 | 8 |
| PDZRN4 | CLEC3B | 0.81604 | 3 | 0 | 3 |
| PDZRN4 | SGCA | 0.813066 | 9 | 0 | 9 |
| PDZRN4 | XKR4 | 0.810667 | 6 | 0 | 5 |
| PDZRN4 | PRUNE2 | 0.808756 | 10 | 0 | 10 |
| PDZRN4 | PLN | 0.808619 | 10 | 0 | 10 |
| PDZRN4 | AOC3 | 0.80831 | 10 | 0 | 10 |
| PDZRN4 | SYNM | 0.807843 | 9 | 0 | 9 |
| PDZRN4 | PYGM | 0.807483 | 9 | 0 | 8 |
| PDZRN4 | MBNL1-AS1 | 0.799317 | 3 | 0 | 3 |
| PDZRN4 | CDH19 | 0.7985 | 9 | 0 | 9 |
| PDZRN4 | HSPB7 | 0.798409 | 10 | 0 | 10 |
| PDZRN4 | CACNB2 | 0.790296 | 8 | 0 | 7 |
| PDZRN4 | C1QTNF7 | 0.789863 | 6 | 0 | 6 |
For details and further investigation, click here
