| Full name: myotilin | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q31.2 | ||
| Entrez ID: 9499 | HGNC ID: HGNC:12399 | Ensembl Gene: ENSG00000120729 | OMIM ID: 604103 |
| Drug and gene relationship at DGIdb | |||
Expression of MYOT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MYOT | 9499 | 219728_at | -1.0075 | 0.4909 | |
| GSE20347 | MYOT | 9499 | 219728_at | -0.1491 | 0.3898 | |
| GSE23400 | MYOT | 9499 | 219728_at | -0.0811 | 0.4286 | |
| GSE26886 | MYOT | 9499 | 219728_at | 0.1377 | 0.2774 | |
| GSE29001 | MYOT | 9499 | 219728_at | -0.3860 | 0.0805 | |
| GSE38129 | MYOT | 9499 | 219728_at | -0.9813 | 0.0116 | |
| GSE45670 | MYOT | 9499 | 219728_at | -1.5849 | 0.0000 | |
| GSE53622 | MYOT | 9499 | 134531 | -0.8397 | 0.0000 | |
| GSE53624 | MYOT | 9499 | 134531 | -1.2476 | 0.0000 | |
| GSE63941 | MYOT | 9499 | 219728_at | 0.0776 | 0.7922 | |
| GSE77861 | MYOT | 9499 | 219728_at | -0.0464 | 0.6396 | |
| GSE97050 | MYOT | 9499 | A_23_P110764 | -1.1414 | 0.1581 | |
| SRP064894 | MYOT | 9499 | RNAseq | -0.0138 | 0.9684 | |
| SRP133303 | MYOT | 9499 | RNAseq | 0.2210 | 0.6697 | |
| SRP159526 | MYOT | 9499 | RNAseq | -0.0646 | 0.9181 | |
| TCGA | MYOT | 9499 | RNAseq | -1.3942 | 0.0006 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by MYOT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MYOT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MYOT | 9499 | 3 | 10 | 17 | |
| GSE20123 | MYOT | 9499 | 4 | 10 | 16 | |
| GSE43470 | MYOT | 9499 | 4 | 7 | 32 | |
| GSE46452 | MYOT | 9499 | 0 | 27 | 32 | |
| GSE47630 | MYOT | 9499 | 0 | 21 | 19 | |
| GSE54993 | MYOT | 9499 | 9 | 1 | 60 | |
| GSE54994 | MYOT | 9499 | 3 | 13 | 37 | |
| GSE60625 | MYOT | 9499 | 0 | 0 | 11 | |
| GSE74703 | MYOT | 9499 | 3 | 5 | 28 | |
| GSE74704 | MYOT | 9499 | 3 | 4 | 13 | |
| TCGA | MYOT | 9499 | 4 | 36 | 56 |
Total number of gains: 33; Total number of losses: 134; Total Number of normals: 321.
Somatic mutations of MYOT:
Generating mutation plots.
Highly correlated genes for MYOT:
Showing top 20/967 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MYOT | ADAMTSL1 | 0.807663 | 5 | 0 | 5 |
| MYOT | NEGR1 | 0.806887 | 5 | 0 | 5 |
| MYOT | IQUB | 0.800345 | 3 | 0 | 3 |
| MYOT | CDH19 | 0.79857 | 8 | 0 | 8 |
| MYOT | ANO5 | 0.779789 | 5 | 0 | 5 |
| MYOT | ALDH1A2 | 0.777292 | 4 | 0 | 4 |
| MYOT | CCDC136 | 0.775165 | 3 | 0 | 3 |
| MYOT | DDX42 | 0.769996 | 3 | 0 | 3 |
| MYOT | BHMT2 | 0.769161 | 9 | 0 | 8 |
| MYOT | KLHL41 | 0.76709 | 6 | 0 | 6 |
| MYOT | MYOC | 0.763509 | 9 | 0 | 8 |
| MYOT | MAMDC2 | 0.75059 | 5 | 0 | 5 |
| MYOT | ARHGAP6 | 0.749972 | 9 | 0 | 8 |
| MYOT | PDZRN4 | 0.748144 | 10 | 0 | 9 |
| MYOT | GABRA5 | 0.746561 | 5 | 0 | 4 |
| MYOT | DACT3 | 0.744825 | 5 | 0 | 5 |
| MYOT | PTCHD1 | 0.743883 | 5 | 0 | 5 |
| MYOT | ITGA7 | 0.743042 | 8 | 0 | 8 |
| MYOT | LMO3 | 0.741139 | 10 | 0 | 10 |
| MYOT | NCAM1 | 0.740714 | 8 | 0 | 8 |
For details and further investigation, click here
