| Full name: F-box and leucine rich repeat protein 16 | Alias Symbol: MGC33974|Fbl16 | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 146330 | HGNC ID: HGNC:14150 | Ensembl Gene: ENSG00000127585 | OMIM ID: 609082 |
| Drug and gene relationship at DGIdb | |||
Expression of FBXL16:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FBXL16 | 146330 | 227641_at | -2.0470 | 0.0702 | |
| GSE26886 | FBXL16 | 146330 | 227641_at | -1.4380 | 0.0001 | |
| GSE45670 | FBXL16 | 146330 | 227641_at | -1.1248 | 0.0222 | |
| GSE53622 | FBXL16 | 146330 | 16983 | -2.0049 | 0.0000 | |
| GSE53624 | FBXL16 | 146330 | 16983 | -2.1208 | 0.0000 | |
| GSE63941 | FBXL16 | 146330 | 227641_at | 2.4803 | 0.0151 | |
| GSE77861 | FBXL16 | 146330 | 227641_at | -1.4524 | 0.0021 | |
| GSE97050 | FBXL16 | 146330 | A_23_P406385 | -0.6551 | 0.2870 | |
| SRP007169 | FBXL16 | 146330 | RNAseq | -2.3722 | 0.0000 | |
| SRP008496 | FBXL16 | 146330 | RNAseq | -2.6948 | 0.0000 | |
| SRP064894 | FBXL16 | 146330 | RNAseq | -2.1065 | 0.0000 | |
| SRP133303 | FBXL16 | 146330 | RNAseq | -2.1761 | 0.0000 | |
| SRP159526 | FBXL16 | 146330 | RNAseq | -2.6100 | 0.0000 | |
| SRP193095 | FBXL16 | 146330 | RNAseq | -1.6742 | 0.0000 | |
| SRP219564 | FBXL16 | 146330 | RNAseq | -2.6480 | 0.0015 | |
| TCGA | FBXL16 | 146330 | RNAseq | 0.0892 | 0.6276 |
Upregulated datasets: 1; Downregulated datasets: 12.
Survival by FBXL16 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FBXL16:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FBXL16 | 146330 | 5 | 5 | 20 | |
| GSE20123 | FBXL16 | 146330 | 5 | 4 | 21 | |
| GSE43470 | FBXL16 | 146330 | 4 | 7 | 32 | |
| GSE46452 | FBXL16 | 146330 | 38 | 1 | 20 | |
| GSE47630 | FBXL16 | 146330 | 13 | 6 | 21 | |
| GSE54993 | FBXL16 | 146330 | 3 | 5 | 62 | |
| GSE54994 | FBXL16 | 146330 | 5 | 9 | 39 | |
| GSE60625 | FBXL16 | 146330 | 4 | 0 | 7 | |
| GSE74703 | FBXL16 | 146330 | 4 | 5 | 27 | |
| GSE74704 | FBXL16 | 146330 | 3 | 2 | 15 | |
| TCGA | FBXL16 | 146330 | 20 | 15 | 61 |
Total number of gains: 104; Total number of losses: 59; Total Number of normals: 325.
Somatic mutations of FBXL16:
Generating mutation plots.
Highly correlated genes for FBXL16:
Showing top 20/1404 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FBXL16 | SLC16A6 | 0.808582 | 7 | 0 | 7 |
| FBXL16 | TTC9 | 0.800241 | 7 | 0 | 7 |
| FBXL16 | ENDOU | 0.799106 | 7 | 0 | 7 |
| FBXL16 | DEGS2 | 0.795356 | 6 | 0 | 6 |
| FBXL16 | CYSRT1 | 0.793411 | 6 | 0 | 6 |
| FBXL16 | MAPK3 | 0.790969 | 7 | 0 | 7 |
| FBXL16 | GBP6 | 0.789763 | 4 | 0 | 4 |
| FBXL16 | GDPD3 | 0.788622 | 7 | 0 | 7 |
| FBXL16 | SNORA68 | 0.786654 | 4 | 0 | 4 |
| FBXL16 | NUAK2 | 0.77663 | 3 | 0 | 3 |
| FBXL16 | ORMDL2 | 0.775386 | 4 | 0 | 4 |
| FBXL16 | RANBP9 | 0.773864 | 7 | 0 | 7 |
| FBXL16 | ATG9B | 0.769267 | 7 | 0 | 7 |
| FBXL16 | EPGN | 0.768682 | 3 | 0 | 3 |
| FBXL16 | PTK6 | 0.768172 | 6 | 0 | 6 |
| FBXL16 | GYS2 | 0.766523 | 6 | 0 | 6 |
| FBXL16 | ANXA9 | 0.766412 | 7 | 0 | 7 |
| FBXL16 | SLC46A2 | 0.766254 | 7 | 0 | 7 |
| FBXL16 | ABLIM1 | 0.766168 | 7 | 0 | 7 |
| FBXL16 | PHACTR4 | 0.765901 | 7 | 0 | 7 |
For details and further investigation, click here
