| Full name: F-box and leucine rich repeat protein 22 | Alias Symbol: Fbl22|FLJ39626 | ||
| Type: protein-coding gene | Cytoband: 15q22.31 | ||
| Entrez ID: 283807 | HGNC ID: HGNC:27537 | Ensembl Gene: ENSG00000197361 | OMIM ID: 609088 |
| Drug and gene relationship at DGIdb | |||
Expression of FBXL22:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FBXL22 | 283807 | 241350_at | -0.9107 | 0.0567 | |
| GSE26886 | FBXL22 | 283807 | 241350_at | 0.1906 | 0.1003 | |
| GSE45670 | FBXL22 | 283807 | 241350_at | -0.7873 | 0.0000 | |
| GSE53622 | FBXL22 | 283807 | 159836 | -0.5932 | 0.0001 | |
| GSE53624 | FBXL22 | 283807 | 159836 | -0.7773 | 0.0000 | |
| GSE63941 | FBXL22 | 283807 | 241350_at | 0.0943 | 0.6678 | |
| GSE77861 | FBXL22 | 283807 | 241350_at | -0.0428 | 0.6834 | |
| GSE97050 | FBXL22 | 283807 | A_33_P3277674 | -0.5483 | 0.1754 | |
| SRP064894 | FBXL22 | 283807 | RNAseq | -0.9120 | 0.0310 | |
| SRP133303 | FBXL22 | 283807 | RNAseq | -0.8076 | 0.1083 | |
| SRP159526 | FBXL22 | 283807 | RNAseq | -1.1888 | 0.0330 | |
| SRP193095 | FBXL22 | 283807 | RNAseq | -0.3294 | 0.0513 | |
| SRP219564 | FBXL22 | 283807 | RNAseq | -0.6289 | 0.5316 | |
| TCGA | FBXL22 | 283807 | RNAseq | -0.6939 | 0.0008 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by FBXL22 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FBXL22:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FBXL22 | 283807 | 8 | 2 | 20 | |
| GSE20123 | FBXL22 | 283807 | 8 | 2 | 20 | |
| GSE43470 | FBXL22 | 283807 | 4 | 6 | 33 | |
| GSE46452 | FBXL22 | 283807 | 3 | 7 | 49 | |
| GSE47630 | FBXL22 | 283807 | 8 | 10 | 22 | |
| GSE54993 | FBXL22 | 283807 | 5 | 6 | 59 | |
| GSE54994 | FBXL22 | 283807 | 6 | 8 | 39 | |
| GSE60625 | FBXL22 | 283807 | 4 | 0 | 7 | |
| GSE74703 | FBXL22 | 283807 | 4 | 3 | 29 | |
| GSE74704 | FBXL22 | 283807 | 4 | 2 | 14 | |
| TCGA | FBXL22 | 283807 | 10 | 16 | 70 |
Total number of gains: 64; Total number of losses: 62; Total Number of normals: 362.
Somatic mutations of FBXL22:
Generating mutation plots.
Highly correlated genes for FBXL22:
Showing top 20/421 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FBXL22 | DACT3 | 0.755122 | 7 | 0 | 7 |
| FBXL22 | ANGPTL1 | 0.754923 | 4 | 0 | 4 |
| FBXL22 | RAB9B | 0.751105 | 4 | 0 | 4 |
| FBXL22 | NEGR1 | 0.734828 | 5 | 0 | 5 |
| FBXL22 | SCN7A | 0.733243 | 5 | 0 | 5 |
| FBXL22 | RAI2 | 0.731288 | 5 | 0 | 5 |
| FBXL22 | RYR2 | 0.728803 | 5 | 0 | 5 |
| FBXL22 | HPSE2 | 0.724788 | 4 | 0 | 4 |
| FBXL22 | PDK4 | 0.723625 | 5 | 0 | 5 |
| FBXL22 | ITGA1 | 0.712013 | 3 | 0 | 3 |
| FBXL22 | ADCY5 | 0.711175 | 5 | 0 | 5 |
| FBXL22 | FENDRR | 0.709799 | 5 | 0 | 5 |
| FBXL22 | COX7A1 | 0.709615 | 5 | 0 | 5 |
| FBXL22 | SH3BGR | 0.70561 | 5 | 0 | 5 |
| FBXL22 | PGM5 | 0.702812 | 7 | 0 | 6 |
| FBXL22 | MYOM1 | 0.701354 | 6 | 0 | 5 |
| FBXL22 | PTCHD1 | 0.700903 | 5 | 0 | 5 |
| FBXL22 | PDE5A | 0.700644 | 5 | 0 | 4 |
| FBXL22 | C1QTNF7 | 0.699504 | 4 | 0 | 4 |
| FBXL22 | OGN | 0.698772 | 4 | 0 | 3 |
For details and further investigation, click here
