| Full name: ryanodine receptor 2 | Alias Symbol: ARVC2|VTSIP | ||
| Type: protein-coding gene | Cytoband: 1q43 | ||
| Entrez ID: 6262 | HGNC ID: HGNC:10484 | Ensembl Gene: ENSG00000198626 | OMIM ID: 180902 |
| Drug and gene relationship at DGIdb | |||
RYR2 involved pathways:
Expression of RYR2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RYR2 | 6262 | 214044_at | -2.0180 | 0.1833 | |
| GSE20347 | RYR2 | 6262 | 207557_s_at | 0.0937 | 0.5733 | |
| GSE23400 | RYR2 | 6262 | 214044_at | -0.2618 | 0.0045 | |
| GSE26886 | RYR2 | 6262 | 207557_s_at | 0.2076 | 0.0306 | |
| GSE29001 | RYR2 | 6262 | 207557_s_at | -0.0223 | 0.9566 | |
| GSE38129 | RYR2 | 6262 | 207557_s_at | -0.6807 | 0.0876 | |
| GSE45670 | RYR2 | 6262 | 207557_s_at | -1.3052 | 0.0077 | |
| GSE53622 | RYR2 | 6262 | 18156 | -1.2708 | 0.0000 | |
| GSE53624 | RYR2 | 6262 | 12016 | -1.4810 | 0.0000 | |
| GSE63941 | RYR2 | 6262 | 207557_s_at | -0.3880 | 0.1270 | |
| GSE77861 | RYR2 | 6262 | 207557_s_at | 0.0131 | 0.9018 | |
| GSE97050 | RYR2 | 6262 | A_33_P3251727 | -1.2935 | 0.1673 | |
| SRP064894 | RYR2 | 6262 | RNAseq | -0.9133 | 0.0695 | |
| SRP133303 | RYR2 | 6262 | RNAseq | -0.9098 | 0.1663 | |
| SRP159526 | RYR2 | 6262 | RNAseq | -1.2842 | 0.0204 | |
| SRP193095 | RYR2 | 6262 | RNAseq | 0.3716 | 0.4024 | |
| SRP219564 | RYR2 | 6262 | RNAseq | -0.7840 | 0.5152 | |
| TCGA | RYR2 | 6262 | RNAseq | -1.2343 | 0.0006 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by RYR2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RYR2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RYR2 | 6262 | 10 | 1 | 19 | |
| GSE20123 | RYR2 | 6262 | 10 | 1 | 19 | |
| GSE43470 | RYR2 | 6262 | 8 | 1 | 34 | |
| GSE46452 | RYR2 | 6262 | 4 | 2 | 53 | |
| GSE47630 | RYR2 | 6262 | 15 | 0 | 25 | |
| GSE54993 | RYR2 | 6262 | 0 | 6 | 64 | |
| GSE54994 | RYR2 | 6262 | 16 | 0 | 37 | |
| GSE60625 | RYR2 | 6262 | 0 | 0 | 11 | |
| GSE74703 | RYR2 | 6262 | 8 | 1 | 27 | |
| GSE74704 | RYR2 | 6262 | 4 | 0 | 16 | |
| TCGA | RYR2 | 6262 | 43 | 4 | 49 |
Total number of gains: 118; Total number of losses: 16; Total Number of normals: 354.
Somatic mutations of RYR2:
Generating mutation plots.
Highly correlated genes for RYR2:
Showing top 20/674 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RYR2 | PLA2G5 | 0.794177 | 6 | 0 | 6 |
| RYR2 | KIAA0408 | 0.765111 | 5 | 0 | 5 |
| RYR2 | ANO5 | 0.764249 | 5 | 0 | 5 |
| RYR2 | RBFOX3 | 0.764198 | 3 | 0 | 3 |
| RYR2 | PYGM | 0.761719 | 7 | 0 | 6 |
| RYR2 | MBNL1-AS1 | 0.756089 | 3 | 0 | 3 |
| RYR2 | ACACB | 0.752656 | 6 | 0 | 6 |
| RYR2 | MYOM1 | 0.74187 | 9 | 0 | 7 |
| RYR2 | EPM2A | 0.738946 | 6 | 0 | 5 |
| RYR2 | MORN5 | 0.738786 | 3 | 0 | 3 |
| RYR2 | CACNB2 | 0.738099 | 7 | 0 | 6 |
| RYR2 | TLN1 | 0.736759 | 4 | 0 | 4 |
| RYR2 | CSRP1 | 0.736251 | 7 | 0 | 7 |
| RYR2 | PGM5 | 0.730796 | 7 | 0 | 7 |
| RYR2 | ARHGEF25 | 0.729799 | 5 | 0 | 4 |
| RYR2 | SCN7A | 0.728936 | 7 | 0 | 7 |
| RYR2 | FBXL22 | 0.728803 | 5 | 0 | 5 |
| RYR2 | AQP1 | 0.728307 | 7 | 0 | 6 |
| RYR2 | PDZRN4 | 0.724685 | 9 | 0 | 8 |
| RYR2 | VIP | 0.722566 | 6 | 0 | 5 |
For details and further investigation, click here
