FBXL6

 

Full name: F-box and leucine rich repeat protein 6 Alias Symbol: FBL6
Type: protein-coding gene Cytoband: 8q24.3
Entrez ID: 26233 HGNC ID: HGNC:13603 Ensembl Gene: ENSG00000182325 OMIM ID: 609076
Drug and gene relationship at DGIdb

 

Expression of FBXL6:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FBXL6 26233 219189_at 1.2074 0.0438
GSE20347 FBXL6 26233 219189_at 0.4267 0.0041
GSE23400 FBXL6 26233 219189_at 0.4432 0.0000
GSE26886 FBXL6 26233 239416_at 0.1175 0.2885
GSE29001 FBXL6 26233 219189_at 0.2251 0.2011
GSE38129 FBXL6 26233 219189_at 0.5936 0.0012
GSE45670 FBXL6 26233 219189_at 0.5081 0.0062
GSE53622 FBXL6 26233 3896 0.6203 0.0000
GSE53624 FBXL6 26233 3896 0.7157 0.0000
GSE63941 FBXL6 26233 219189_at 1.2527 0.0091
GSE77861 FBXL6 26233 219189_at 0.1903 0.3302
GSE97050 FBXL6 26233 A_33_P3284646 0.5731 0.1095
SRP007169 FBXL6 26233 RNAseq -0.2277 0.6695
SRP008496 FBXL6 26233 RNAseq 0.0798 0.8068
SRP064894 FBXL6 26233 RNAseq 1.4997 0.0000
SRP133303 FBXL6 26233 RNAseq 0.5401 0.0027
SRP159526 FBXL6 26233 RNAseq 0.7007 0.0169
SRP193095 FBXL6 26233 RNAseq 0.6329 0.0004
TCGA FBXL6 26233 RNAseq 0.3284 0.0000

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by FBXL6 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FBXL6:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FBXL6 26233 17 1 12
GSE20123 FBXL6 26233 17 1 12
GSE43470 FBXL6 26233 16 2 25
GSE46452 FBXL6 26233 28 0 31
GSE47630 FBXL6 26233 25 1 14
GSE54993 FBXL6 26233 0 25 45
GSE54994 FBXL6 26233 39 1 13
GSE60625 FBXL6 26233 3 4 4
GSE74703 FBXL6 26233 14 1 21
GSE74704 FBXL6 26233 10 0 10
TCGA FBXL6 26233 63 2 31

Total number of gains: 232; Total number of losses: 38; Total Number of normals: 218.  

 

Somatic mutations of FBXL6:

 

Generating mutation plots.

 

Highly correlated genes for FBXL6:

 

Showing top 20/1300 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FBXL6CMTM40.789156303
FBXL6PRRC2C0.788737303
FBXL6COMMD50.766341404
FBXL6PSPC10.755942303
FBXL6GGN0.744907404
FBXL6SLC41A10.731053303
FBXL6MRPL380.722147404
FBXL6KRTCAP20.722056404
FBXL6ZNF4960.721817303
FBXL6RNF40.710046403
FBXL6EGLN20.708872303
FBXL6EBNA1BP20.708656303
FBXL6WDR40.707456504
FBXL6LRRC8A0.706211303
FBXL6VGLL40.704973303
FBXL6ENPEP0.702692303
FBXL6SAMD10.698097808
FBXL6EXOSC40.69715912010
FBXL6DAB2IP0.696867303
FBXL6PPP5C0.69489504

For details and further investigation, click here