| Full name: exosome component 4 | Alias Symbol: hRrp41p|FLJ20591|Rrp41p|RRP41|RRP41A|Ski6p|SKI6|p12A | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 54512 | HGNC ID: HGNC:18189 | Ensembl Gene: ENSG00000178896 | OMIM ID: 606491 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of EXOSC4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EXOSC4 | 54512 | 58696_at | 1.1237 | 0.0103 | |
| GSE20347 | EXOSC4 | 54512 | 58696_at | 0.3339 | 0.0109 | |
| GSE23400 | EXOSC4 | 54512 | 58696_at | 0.4918 | 0.0000 | |
| GSE26886 | EXOSC4 | 54512 | 218695_at | 0.7266 | 0.0050 | |
| GSE29001 | EXOSC4 | 54512 | 58696_at | 0.4482 | 0.1011 | |
| GSE38129 | EXOSC4 | 54512 | 58696_at | 0.4441 | 0.0000 | |
| GSE45670 | EXOSC4 | 54512 | 58696_at | 0.6676 | 0.0009 | |
| GSE53622 | EXOSC4 | 54512 | 147193 | 0.7975 | 0.0000 | |
| GSE53624 | EXOSC4 | 54512 | 147193 | 1.0825 | 0.0000 | |
| GSE63941 | EXOSC4 | 54512 | 58696_at | 1.0376 | 0.0359 | |
| GSE77861 | EXOSC4 | 54512 | 58696_at | 0.2786 | 0.0859 | |
| GSE97050 | EXOSC4 | 54512 | A_33_P3301410 | 0.4680 | 0.2501 | |
| SRP007169 | EXOSC4 | 54512 | RNAseq | -0.3898 | 0.2812 | |
| SRP008496 | EXOSC4 | 54512 | RNAseq | -0.1642 | 0.5642 | |
| SRP064894 | EXOSC4 | 54512 | RNAseq | 1.2415 | 0.0028 | |
| SRP133303 | EXOSC4 | 54512 | RNAseq | 0.6204 | 0.0049 | |
| SRP159526 | EXOSC4 | 54512 | RNAseq | 0.7328 | 0.0213 | |
| SRP193095 | EXOSC4 | 54512 | RNAseq | 0.6070 | 0.0007 | |
| SRP219564 | EXOSC4 | 54512 | RNAseq | 0.6491 | 0.1084 | |
| TCGA | EXOSC4 | 54512 | RNAseq | 0.3305 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by EXOSC4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EXOSC4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EXOSC4 | 54512 | 17 | 1 | 12 | |
| GSE20123 | EXOSC4 | 54512 | 17 | 1 | 12 | |
| GSE43470 | EXOSC4 | 54512 | 16 | 2 | 25 | |
| GSE46452 | EXOSC4 | 54512 | 27 | 0 | 32 | |
| GSE47630 | EXOSC4 | 54512 | 23 | 1 | 16 | |
| GSE54993 | EXOSC4 | 54512 | 0 | 25 | 45 | |
| GSE54994 | EXOSC4 | 54512 | 39 | 1 | 13 | |
| GSE60625 | EXOSC4 | 54512 | 3 | 4 | 4 | |
| GSE74703 | EXOSC4 | 54512 | 14 | 1 | 21 | |
| GSE74704 | EXOSC4 | 54512 | 10 | 0 | 10 | |
| TCGA | EXOSC4 | 54512 | 63 | 2 | 31 |
Total number of gains: 229; Total number of losses: 38; Total Number of normals: 221.
Somatic mutations of EXOSC4:
Generating mutation plots.
Highly correlated genes for EXOSC4:
Showing top 20/1864 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EXOSC4 | ZNF707 | 0.824478 | 3 | 0 | 3 |
| EXOSC4 | TP53RK | 0.793238 | 3 | 0 | 3 |
| EXOSC4 | PUF60 | 0.785217 | 13 | 0 | 13 |
| EXOSC4 | TOP1MT | 0.76431 | 9 | 0 | 8 |
| EXOSC4 | SEMA4C | 0.759004 | 3 | 0 | 3 |
| EXOSC4 | DPP9 | 0.75728 | 4 | 0 | 3 |
| EXOSC4 | RTKN | 0.753063 | 7 | 0 | 7 |
| EXOSC4 | ALKBH6 | 0.74607 | 3 | 0 | 3 |
| EXOSC4 | FAM89A | 0.740514 | 3 | 0 | 3 |
| EXOSC4 | SLC39A3 | 0.725476 | 4 | 0 | 3 |
| EXOSC4 | CXCL16 | 0.72293 | 4 | 0 | 3 |
| EXOSC4 | CIAO1 | 0.721302 | 5 | 0 | 4 |
| EXOSC4 | PPIL4 | 0.718947 | 3 | 0 | 3 |
| EXOSC4 | GDAP1 | 0.71426 | 5 | 0 | 4 |
| EXOSC4 | ANLN | 0.714119 | 5 | 0 | 5 |
| EXOSC4 | PTCD1 | 0.713961 | 3 | 0 | 3 |
| EXOSC4 | NDUFB9 | 0.712232 | 9 | 0 | 8 |
| EXOSC4 | ISG20L2 | 0.711701 | 8 | 0 | 8 |
| EXOSC4 | MRPL17 | 0.710911 | 11 | 0 | 9 |
| EXOSC4 | DNAJB11 | 0.709583 | 6 | 0 | 5 |
For details and further investigation, click here
