| Full name: protein C, inactivator of coagulation factors Va and VIIIa | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q14.3 | ||
| Entrez ID: 5624 | HGNC ID: HGNC:9451 | Ensembl Gene: ENSG00000115718 | OMIM ID: 612283 |
| Drug and gene relationship at DGIdb | |||
PROC involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04610 | Complement and coagulation cascades |
Expression of PROC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PROC | 5624 | 206259_at | 0.3546 | 0.3210 | |
| GSE20347 | PROC | 5624 | 206259_at | 0.0878 | 0.2852 | |
| GSE23400 | PROC | 5624 | 206259_at | -0.0694 | 0.1201 | |
| GSE26886 | PROC | 5624 | 206259_at | 1.1473 | 0.0000 | |
| GSE29001 | PROC | 5624 | 206259_at | 0.4825 | 0.1732 | |
| GSE38129 | PROC | 5624 | 206259_at | 0.0576 | 0.7108 | |
| GSE45670 | PROC | 5624 | 206259_at | 0.2559 | 0.1167 | |
| GSE53622 | PROC | 5624 | 75276 | 1.3865 | 0.0000 | |
| GSE53624 | PROC | 5624 | 75276 | 1.5877 | 0.0000 | |
| GSE63941 | PROC | 5624 | 206259_at | 0.9946 | 0.1635 | |
| GSE77861 | PROC | 5624 | 206259_at | 0.0122 | 0.9412 | |
| GSE97050 | PROC | 5624 | A_33_P3379922 | 0.0979 | 0.7460 | |
| SRP133303 | PROC | 5624 | RNAseq | 1.8961 | 0.0000 | |
| SRP159526 | PROC | 5624 | RNAseq | 2.0245 | 0.0030 | |
| TCGA | PROC | 5624 | RNAseq | -0.2335 | 0.5300 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by PROC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PROC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PROC | 5624 | 5 | 3 | 22 | |
| GSE20123 | PROC | 5624 | 6 | 3 | 21 | |
| GSE43470 | PROC | 5624 | 2 | 1 | 40 | |
| GSE46452 | PROC | 5624 | 1 | 3 | 55 | |
| GSE47630 | PROC | 5624 | 6 | 0 | 34 | |
| GSE54993 | PROC | 5624 | 0 | 6 | 64 | |
| GSE54994 | PROC | 5624 | 11 | 0 | 42 | |
| GSE60625 | PROC | 5624 | 0 | 3 | 8 | |
| GSE74703 | PROC | 5624 | 2 | 1 | 33 | |
| GSE74704 | PROC | 5624 | 3 | 1 | 16 | |
| TCGA | PROC | 5624 | 22 | 8 | 66 |
Total number of gains: 58; Total number of losses: 29; Total Number of normals: 401.
Somatic mutations of PROC:
Generating mutation plots.
Highly correlated genes for PROC:
Showing top 20/425 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PROC | MGAT5B | 0.776905 | 3 | 0 | 3 |
| PROC | ZFPM1 | 0.77444 | 3 | 0 | 3 |
| PROC | JSRP1 | 0.767264 | 3 | 0 | 3 |
| PROC | SPRED3 | 0.766668 | 3 | 0 | 3 |
| PROC | NPW | 0.763896 | 4 | 0 | 3 |
| PROC | CHRD | 0.761079 | 3 | 0 | 3 |
| PROC | MAPK15 | 0.755889 | 3 | 0 | 3 |
| PROC | TSPAN10 | 0.750128 | 4 | 0 | 4 |
| PROC | TMEM102 | 0.745847 | 4 | 0 | 3 |
| PROC | RETN | 0.73534 | 3 | 0 | 3 |
| PROC | CDH4 | 0.733363 | 3 | 0 | 3 |
| PROC | FGF17 | 0.728367 | 3 | 0 | 3 |
| PROC | PEX11G | 0.7226 | 3 | 0 | 3 |
| PROC | EGR4 | 0.721375 | 4 | 0 | 4 |
| PROC | GLTPD2 | 0.70573 | 4 | 0 | 3 |
| PROC | TOR2A | 0.703575 | 3 | 0 | 3 |
| PROC | RFX8 | 0.703209 | 3 | 0 | 3 |
| PROC | SLC18A3 | 0.702284 | 4 | 0 | 4 |
| PROC | FFAR1 | 0.701769 | 5 | 0 | 5 |
| PROC | DUSP9 | 0.695705 | 6 | 0 | 4 |
For details and further investigation, click here
