| Full name: F-box and WD repeat domain containing 11 | Alias Symbol: KIAA0696|Fbw1b|BTRCP2|BTRC2|Hos|Fbw11 | ||
| Type: protein-coding gene | Cytoband: 5q35.1 | ||
| Entrez ID: 23291 | HGNC ID: HGNC:13607 | Ensembl Gene: ENSG00000072803 | OMIM ID: 605651 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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FBXW11 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04114 | Oocyte meiosis | |
| hsa04310 | Wnt signaling pathway | |
| hsa04340 | Hedgehog signaling pathway | |
| hsa04390 | Hippo signaling pathway | |
| hsa04710 | Circadian rhythm | |
| hsa05131 | Shigellosis |
Expression of FBXW11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FBXW11 | 23291 | 209455_at | -0.3496 | 0.3239 | |
| GSE20347 | FBXW11 | 23291 | 209455_at | -0.9955 | 0.0000 | |
| GSE23400 | FBXW11 | 23291 | 209455_at | -0.7216 | 0.0000 | |
| GSE26886 | FBXW11 | 23291 | 209455_at | -1.3460 | 0.0000 | |
| GSE29001 | FBXW11 | 23291 | 209455_at | -0.8849 | 0.0012 | |
| GSE38129 | FBXW11 | 23291 | 209455_at | -0.7482 | 0.0000 | |
| GSE45670 | FBXW11 | 23291 | 209455_at | -0.2833 | 0.0760 | |
| GSE53622 | FBXW11 | 23291 | 152056 | -0.9455 | 0.0000 | |
| GSE53624 | FBXW11 | 23291 | 152056 | -1.0618 | 0.0000 | |
| GSE63941 | FBXW11 | 23291 | 209455_at | -0.0762 | 0.8567 | |
| GSE77861 | FBXW11 | 23291 | 209455_at | -0.7935 | 0.0293 | |
| GSE97050 | FBXW11 | 23291 | A_23_P214046 | -0.3814 | 0.1657 | |
| SRP007169 | FBXW11 | 23291 | RNAseq | -2.2541 | 0.0000 | |
| SRP008496 | FBXW11 | 23291 | RNAseq | -2.2929 | 0.0000 | |
| SRP064894 | FBXW11 | 23291 | RNAseq | -1.1795 | 0.0000 | |
| SRP133303 | FBXW11 | 23291 | RNAseq | -0.4377 | 0.0016 | |
| SRP159526 | FBXW11 | 23291 | RNAseq | -0.7718 | 0.0604 | |
| SRP193095 | FBXW11 | 23291 | RNAseq | -1.0448 | 0.0000 | |
| SRP219564 | FBXW11 | 23291 | RNAseq | -0.7615 | 0.0044 | |
| TCGA | FBXW11 | 23291 | RNAseq | -0.2594 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by FBXW11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FBXW11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FBXW11 | 23291 | 2 | 13 | 15 | |
| GSE20123 | FBXW11 | 23291 | 2 | 13 | 15 | |
| GSE43470 | FBXW11 | 23291 | 1 | 11 | 31 | |
| GSE46452 | FBXW11 | 23291 | 0 | 27 | 32 | |
| GSE47630 | FBXW11 | 23291 | 0 | 20 | 20 | |
| GSE54993 | FBXW11 | 23291 | 9 | 2 | 59 | |
| GSE54994 | FBXW11 | 23291 | 2 | 15 | 36 | |
| GSE60625 | FBXW11 | 23291 | 1 | 0 | 10 | |
| GSE74703 | FBXW11 | 23291 | 1 | 7 | 28 | |
| GSE74704 | FBXW11 | 23291 | 1 | 6 | 13 | |
| TCGA | FBXW11 | 23291 | 8 | 34 | 54 |
Total number of gains: 27; Total number of losses: 148; Total Number of normals: 313.
Somatic mutations of FBXW11:
Generating mutation plots.
Highly correlated genes for FBXW11:
Showing top 20/1738 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FBXW11 | RMND5B | 0.799555 | 11 | 0 | 11 |
| FBXW11 | ACAA1 | 0.770329 | 8 | 0 | 8 |
| FBXW11 | ARRDC3 | 0.769202 | 7 | 0 | 7 |
| FBXW11 | PPID | 0.763234 | 3 | 0 | 3 |
| FBXW11 | TP53INP2 | 0.759881 | 5 | 0 | 5 |
| FBXW11 | ETFDH | 0.755919 | 10 | 0 | 10 |
| FBXW11 | NAGK | 0.754978 | 11 | 0 | 10 |
| FBXW11 | RAB5B | 0.750784 | 10 | 0 | 10 |
| FBXW11 | BRK1 | 0.749879 | 7 | 0 | 7 |
| FBXW11 | ZNF416 | 0.7488 | 4 | 0 | 4 |
| FBXW11 | CAPN5 | 0.74813 | 11 | 0 | 10 |
| FBXW11 | SORT1 | 0.747049 | 11 | 0 | 11 |
| FBXW11 | VSIG10L | 0.746032 | 6 | 0 | 6 |
| FBXW11 | MXD1 | 0.745583 | 10 | 0 | 10 |
| FBXW11 | RNF10 | 0.745305 | 10 | 0 | 10 |
| FBXW11 | FAM214A | 0.742946 | 6 | 0 | 6 |
| FBXW11 | MTPN | 0.742593 | 7 | 0 | 7 |
| FBXW11 | CUL3 | 0.742287 | 11 | 0 | 10 |
| FBXW11 | SASH1 | 0.74103 | 11 | 0 | 11 |
| FBXW11 | GDPD3 | 0.740474 | 10 | 0 | 10 |
For details and further investigation, click here
