| Full name: Fc fragment of IgA receptor | Alias Symbol: CD89 | ||
| Type: protein-coding gene | Cytoband: 19q13.42 | ||
| Entrez ID: 2204 | HGNC ID: HGNC:3608 | Ensembl Gene: ENSG00000186431 | OMIM ID: 147045 |
| Drug and gene relationship at DGIdb | |||
FCAR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05150 | Staphylococcus aureus infection |
Expression of FCAR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FCAR | 2204 | 211305_x_at | 0.0344 | 0.8839 | |
| GSE20347 | FCAR | 2204 | 211816_x_at | 0.0238 | 0.8302 | |
| GSE23400 | FCAR | 2204 | 211816_x_at | -0.1364 | 0.0000 | |
| GSE26886 | FCAR | 2204 | 211816_x_at | 0.0340 | 0.7616 | |
| GSE29001 | FCAR | 2204 | 211816_x_at | -0.0297 | 0.8497 | |
| GSE38129 | FCAR | 2204 | 211816_x_at | -0.0538 | 0.4368 | |
| GSE45670 | FCAR | 2204 | 211816_x_at | 0.1386 | 0.0738 | |
| GSE53622 | FCAR | 2204 | 3481 | 0.6982 | 0.0004 | |
| GSE53624 | FCAR | 2204 | 3481 | 0.5323 | 0.0002 | |
| GSE63941 | FCAR | 2204 | 211305_x_at | -0.0093 | 0.9438 | |
| GSE77861 | FCAR | 2204 | 211816_x_at | -0.1640 | 0.0868 | |
| GSE97050 | FCAR | 2204 | A_23_P208768 | 0.4710 | 0.2332 | |
| SRP007169 | FCAR | 2204 | RNAseq | 1.2361 | 0.0840 | |
| SRP064894 | FCAR | 2204 | RNAseq | 0.4682 | 0.0977 | |
| SRP133303 | FCAR | 2204 | RNAseq | 0.1652 | 0.2547 | |
| SRP159526 | FCAR | 2204 | RNAseq | 1.1922 | 0.0381 | |
| SRP193095 | FCAR | 2204 | RNAseq | 0.4296 | 0.0117 | |
| SRP219564 | FCAR | 2204 | RNAseq | 0.8773 | 0.0249 | |
| TCGA | FCAR | 2204 | RNAseq | -0.1907 | 0.7399 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by FCAR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FCAR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FCAR | 2204 | 3 | 4 | 23 | |
| GSE20123 | FCAR | 2204 | 3 | 3 | 24 | |
| GSE43470 | FCAR | 2204 | 3 | 11 | 29 | |
| GSE46452 | FCAR | 2204 | 45 | 1 | 13 | |
| GSE47630 | FCAR | 2204 | 8 | 6 | 26 | |
| GSE54993 | FCAR | 2204 | 17 | 4 | 49 | |
| GSE54994 | FCAR | 2204 | 4 | 13 | 36 | |
| GSE60625 | FCAR | 2204 | 9 | 0 | 2 | |
| GSE74703 | FCAR | 2204 | 3 | 7 | 26 | |
| GSE74704 | FCAR | 2204 | 3 | 1 | 16 | |
| TCGA | FCAR | 2204 | 19 | 14 | 63 |
Total number of gains: 117; Total number of losses: 64; Total Number of normals: 307.
Somatic mutations of FCAR:
Generating mutation plots.
Highly correlated genes for FCAR:
Showing top 20/728 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FCAR | DMC1 | 0.732722 | 3 | 0 | 3 |
| FCAR | KCNA1 | 0.732699 | 4 | 0 | 4 |
| FCAR | ATG10 | 0.701728 | 6 | 0 | 5 |
| FCAR | IL5RA | 0.690638 | 4 | 0 | 4 |
| FCAR | FSCN3 | 0.677605 | 4 | 0 | 3 |
| FCAR | CYLC1 | 0.675901 | 3 | 0 | 3 |
| FCAR | IFT122 | 0.675529 | 4 | 0 | 3 |
| FCAR | CHST4 | 0.671056 | 4 | 0 | 4 |
| FCAR | DCC | 0.670648 | 4 | 0 | 4 |
| FCAR | KIR3DL3 | 0.670595 | 5 | 0 | 4 |
| FCAR | SERPINC1 | 0.668335 | 4 | 0 | 4 |
| FCAR | SLC5A7 | 0.667521 | 6 | 0 | 6 |
| FCAR | NXPE4 | 0.666612 | 4 | 0 | 4 |
| FCAR | KCNV1 | 0.664389 | 3 | 0 | 3 |
| FCAR | RFPL2 | 0.663921 | 4 | 0 | 4 |
| FCAR | TSHB | 0.66383 | 5 | 0 | 5 |
| FCAR | MAFF | 0.662934 | 4 | 0 | 3 |
| FCAR | SLC45A2 | 0.659425 | 6 | 0 | 5 |
| FCAR | GALNT8 | 0.657547 | 5 | 0 | 4 |
| FCAR | ZMAT4 | 0.656982 | 7 | 0 | 6 |
For details and further investigation, click here
