| Full name: ladinin 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 3898 | HGNC ID: HGNC:6472 | Ensembl Gene: ENSG00000159166 | OMIM ID: 602314 |
| Drug and gene relationship at DGIdb | |||
Expression of LAD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LAD1 | 3898 | 203287_at | -0.0059 | 0.9955 | |
| GSE20347 | LAD1 | 3898 | 203287_at | -0.8216 | 0.0000 | |
| GSE23400 | LAD1 | 3898 | 203287_at | -0.2602 | 0.0452 | |
| GSE26886 | LAD1 | 3898 | 203287_at | -0.9831 | 0.0002 | |
| GSE29001 | LAD1 | 3898 | 203287_at | -0.5483 | 0.1014 | |
| GSE38129 | LAD1 | 3898 | 203287_at | -0.1736 | 0.7264 | |
| GSE45670 | LAD1 | 3898 | 203287_at | 0.0610 | 0.6908 | |
| GSE53622 | LAD1 | 3898 | 102823 | -0.5820 | 0.0134 | |
| GSE53624 | LAD1 | 3898 | 102823 | -0.7953 | 0.0000 | |
| GSE63941 | LAD1 | 3898 | 203287_at | 1.8400 | 0.0006 | |
| GSE77861 | LAD1 | 3898 | 203287_at | -0.0981 | 0.7973 | |
| GSE97050 | LAD1 | 3898 | A_33_P3303810 | 0.6840 | 0.6154 | |
| SRP007169 | LAD1 | 3898 | RNAseq | -2.2890 | 0.0000 | |
| SRP008496 | LAD1 | 3898 | RNAseq | -2.0111 | 0.0000 | |
| SRP064894 | LAD1 | 3898 | RNAseq | -0.9430 | 0.0161 | |
| SRP133303 | LAD1 | 3898 | RNAseq | -0.8637 | 0.0001 | |
| SRP159526 | LAD1 | 3898 | RNAseq | -0.7719 | 0.1348 | |
| SRP193095 | LAD1 | 3898 | RNAseq | -0.8575 | 0.0000 | |
| SRP219564 | LAD1 | 3898 | RNAseq | -0.6143 | 0.5932 | |
| TCGA | LAD1 | 3898 | RNAseq | 0.4878 | 0.0001 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by LAD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LAD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LAD1 | 3898 | 11 | 0 | 19 | |
| GSE20123 | LAD1 | 3898 | 11 | 0 | 19 | |
| GSE43470 | LAD1 | 3898 | 6 | 0 | 37 | |
| GSE46452 | LAD1 | 3898 | 3 | 1 | 55 | |
| GSE47630 | LAD1 | 3898 | 14 | 0 | 26 | |
| GSE54993 | LAD1 | 3898 | 0 | 6 | 64 | |
| GSE54994 | LAD1 | 3898 | 15 | 0 | 38 | |
| GSE60625 | LAD1 | 3898 | 0 | 0 | 11 | |
| GSE74703 | LAD1 | 3898 | 6 | 0 | 30 | |
| GSE74704 | LAD1 | 3898 | 5 | 0 | 15 | |
| TCGA | LAD1 | 3898 | 43 | 4 | 49 |
Total number of gains: 114; Total number of losses: 11; Total Number of normals: 363.
Somatic mutations of LAD1:
Generating mutation plots.
Highly correlated genes for LAD1:
Showing top 20/1008 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LAD1 | KRT75 | 0.795661 | 3 | 0 | 3 |
| LAD1 | JUP | 0.791451 | 13 | 0 | 13 |
| LAD1 | PKP3 | 0.769668 | 13 | 0 | 12 |
| LAD1 | ARAP2 | 0.759716 | 3 | 0 | 3 |
| LAD1 | S100A11 | 0.757133 | 13 | 0 | 12 |
| LAD1 | NIPAL1 | 0.753278 | 3 | 0 | 3 |
| LAD1 | PTBP3 | 0.746264 | 7 | 0 | 7 |
| LAD1 | S100A16 | 0.746098 | 9 | 0 | 9 |
| LAD1 | GRHL2 | 0.745783 | 6 | 0 | 5 |
| LAD1 | LYPD3 | 0.74503 | 12 | 0 | 12 |
| LAD1 | GNA15 | 0.744439 | 13 | 0 | 12 |
| LAD1 | MAL2 | 0.731923 | 7 | 0 | 6 |
| LAD1 | KRT6C | 0.731847 | 4 | 0 | 3 |
| LAD1 | SDC1 | 0.728217 | 12 | 0 | 10 |
| LAD1 | CAPN1 | 0.726261 | 13 | 0 | 13 |
| LAD1 | PKP1 | 0.725219 | 13 | 0 | 13 |
| LAD1 | TRIM29 | 0.724598 | 13 | 0 | 13 |
| LAD1 | GJB5 | 0.724079 | 11 | 0 | 9 |
| LAD1 | SLC9A3R1 | 0.721709 | 12 | 0 | 12 |
| LAD1 | CTNND1 | 0.717651 | 3 | 0 | 3 |
For details and further investigation, click here
