| Full name: FYVE, RhoGEF and PH domain containing 3 | Alias Symbol: FLJ00004|ZFYVE5 | ||
| Type: protein-coding gene | Cytoband: 9q22.31 | ||
| Entrez ID: 89846 | HGNC ID: HGNC:16027 | Ensembl Gene: ENSG00000127084 | OMIM ID: 617554 |
FGD3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04810 | Regulation of actin cytoskeleton |
Expression of FGD3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FGD3 | 89846 | 227811_at | 0.2345 | 0.7480 | |
| GSE26886 | FGD3 | 89846 | 227811_at | 0.3954 | 0.0967 | |
| GSE45670 | FGD3 | 89846 | 227811_at | 0.1304 | 0.3809 | |
| GSE53622 | FGD3 | 89846 | 13614 | -0.2876 | 0.0783 | |
| GSE53624 | FGD3 | 89846 | 13614 | -0.1916 | 0.1092 | |
| GSE63941 | FGD3 | 89846 | 227811_at | 1.9525 | 0.1110 | |
| GSE77861 | FGD3 | 89846 | 227811_at | 0.2046 | 0.1445 | |
| GSE97050 | FGD3 | 89846 | A_24_P153840 | -0.4328 | 0.5680 | |
| SRP007169 | FGD3 | 89846 | RNAseq | -0.0030 | 0.9969 | |
| SRP064894 | FGD3 | 89846 | RNAseq | 0.7289 | 0.0047 | |
| SRP133303 | FGD3 | 89846 | RNAseq | -0.3125 | 0.1479 | |
| SRP159526 | FGD3 | 89846 | RNAseq | -0.6734 | 0.2188 | |
| SRP193095 | FGD3 | 89846 | RNAseq | 0.3197 | 0.1382 | |
| SRP219564 | FGD3 | 89846 | RNAseq | 0.7122 | 0.0243 | |
| TCGA | FGD3 | 89846 | RNAseq | 0.3700 | 0.0048 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by FGD3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FGD3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FGD3 | 89846 | 5 | 9 | 16 | |
| GSE20123 | FGD3 | 89846 | 5 | 9 | 16 | |
| GSE43470 | FGD3 | 89846 | 6 | 3 | 34 | |
| GSE46452 | FGD3 | 89846 | 6 | 14 | 39 | |
| GSE47630 | FGD3 | 89846 | 1 | 17 | 22 | |
| GSE54993 | FGD3 | 89846 | 4 | 2 | 64 | |
| GSE54994 | FGD3 | 89846 | 8 | 11 | 34 | |
| GSE60625 | FGD3 | 89846 | 0 | 0 | 11 | |
| GSE74703 | FGD3 | 89846 | 5 | 3 | 28 | |
| GSE74704 | FGD3 | 89846 | 2 | 7 | 11 | |
| TCGA | FGD3 | 89846 | 24 | 23 | 49 |
Total number of gains: 66; Total number of losses: 98; Total Number of normals: 324.
Somatic mutations of FGD3:
Generating mutation plots.
Highly correlated genes for FGD3:
Showing top 20/310 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FGD3 | SNX20 | 0.710627 | 5 | 0 | 4 |
| FGD3 | SCAMP3 | 0.710261 | 3 | 0 | 3 |
| FGD3 | TRAT1 | 0.69678 | 3 | 0 | 3 |
| FGD3 | ACAP1 | 0.696689 | 5 | 0 | 5 |
| FGD3 | SCARA3 | 0.694118 | 3 | 0 | 3 |
| FGD3 | PSMC4 | 0.685931 | 3 | 0 | 3 |
| FGD3 | WDR81 | 0.685293 | 4 | 0 | 4 |
| FGD3 | PRKX | 0.672812 | 3 | 0 | 3 |
| FGD3 | LGALS8 | 0.661264 | 4 | 0 | 4 |
| FGD3 | BTN2A2 | 0.656936 | 3 | 0 | 3 |
| FGD3 | NCOA5 | 0.654927 | 3 | 0 | 3 |
| FGD3 | C1orf162 | 0.654579 | 4 | 0 | 4 |
| FGD3 | BIN2 | 0.653968 | 5 | 0 | 4 |
| FGD3 | SMAD1 | 0.653804 | 3 | 0 | 3 |
| FGD3 | TNFSF8 | 0.650665 | 4 | 0 | 4 |
| FGD3 | TRRAP | 0.64897 | 3 | 0 | 3 |
| FGD3 | FXYD3 | 0.648389 | 5 | 0 | 4 |
| FGD3 | NAT10 | 0.645551 | 3 | 0 | 3 |
| FGD3 | FBXL4 | 0.645136 | 3 | 0 | 3 |
| FGD3 | GAPT | 0.644605 | 4 | 0 | 4 |
For details and further investigation, click here
