| Full name: proteasome 26S subunit, ATPase 4 | Alias Symbol: TBP7|S6|MGC8570|MGC13687|MGC23214|TBP-7 | ||
| Type: protein-coding gene | Cytoband: 19q13.11-q13.13 | ||
| Entrez ID: 5704 | HGNC ID: HGNC:9551 | Ensembl Gene: ENSG00000013275 | OMIM ID: 602707 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PSMC4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PSMC4 | 5704 | 201252_at | 0.2166 | 0.5762 | |
| GSE20347 | PSMC4 | 5704 | 201252_at | 0.3012 | 0.0787 | |
| GSE23400 | PSMC4 | 5704 | 201252_at | 0.4420 | 0.0000 | |
| GSE26886 | PSMC4 | 5704 | 201252_at | 0.4956 | 0.0016 | |
| GSE29001 | PSMC4 | 5704 | 201252_at | 0.1139 | 0.6525 | |
| GSE38129 | PSMC4 | 5704 | 201252_at | 0.6075 | 0.0000 | |
| GSE45670 | PSMC4 | 5704 | 201252_at | 0.3499 | 0.0159 | |
| GSE53622 | PSMC4 | 5704 | 42396 | 0.3624 | 0.0000 | |
| GSE53624 | PSMC4 | 5704 | 42396 | 0.5168 | 0.0000 | |
| GSE63941 | PSMC4 | 5704 | 201252_at | 1.0309 | 0.0256 | |
| GSE77861 | PSMC4 | 5704 | 201252_at | 0.5625 | 0.0362 | |
| GSE97050 | PSMC4 | 5704 | A_24_P91310 | 0.5480 | 0.0972 | |
| SRP007169 | PSMC4 | 5704 | RNAseq | -0.2242 | 0.4745 | |
| SRP008496 | PSMC4 | 5704 | RNAseq | -0.2985 | 0.1075 | |
| SRP064894 | PSMC4 | 5704 | RNAseq | 0.4194 | 0.0180 | |
| SRP133303 | PSMC4 | 5704 | RNAseq | 0.6577 | 0.0026 | |
| SRP159526 | PSMC4 | 5704 | RNAseq | 0.7788 | 0.0002 | |
| SRP193095 | PSMC4 | 5704 | RNAseq | 0.3797 | 0.0002 | |
| SRP219564 | PSMC4 | 5704 | RNAseq | 0.6829 | 0.0737 | |
| TCGA | PSMC4 | 5704 | RNAseq | 0.2066 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PSMC4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PSMC4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PSMC4 | 5704 | 7 | 4 | 19 | |
| GSE20123 | PSMC4 | 5704 | 7 | 3 | 20 | |
| GSE43470 | PSMC4 | 5704 | 3 | 9 | 31 | |
| GSE46452 | PSMC4 | 5704 | 48 | 1 | 10 | |
| GSE47630 | PSMC4 | 5704 | 9 | 5 | 26 | |
| GSE54993 | PSMC4 | 5704 | 17 | 3 | 50 | |
| GSE54994 | PSMC4 | 5704 | 8 | 9 | 36 | |
| GSE60625 | PSMC4 | 5704 | 9 | 0 | 2 | |
| GSE74703 | PSMC4 | 5704 | 3 | 6 | 27 | |
| GSE74704 | PSMC4 | 5704 | 7 | 1 | 12 | |
| TCGA | PSMC4 | 5704 | 14 | 16 | 66 |
Total number of gains: 132; Total number of losses: 57; Total Number of normals: 299.
Somatic mutations of PSMC4:
Generating mutation plots.
Highly correlated genes for PSMC4:
Showing top 20/965 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PSMC4 | COMMD9 | 0.792481 | 3 | 0 | 3 |
| PSMC4 | MFGE8 | 0.781903 | 4 | 0 | 4 |
| PSMC4 | RILPL1 | 0.762816 | 3 | 0 | 3 |
| PSMC4 | ZHX2 | 0.755324 | 3 | 0 | 3 |
| PSMC4 | PDZD11 | 0.755083 | 3 | 0 | 3 |
| PSMC4 | PIAS3 | 0.748284 | 3 | 0 | 3 |
| PSMC4 | SLC39A3 | 0.74656 | 3 | 0 | 3 |
| PSMC4 | CRTC2 | 0.738486 | 3 | 0 | 3 |
| PSMC4 | LDLRAP1 | 0.722795 | 3 | 0 | 3 |
| PSMC4 | MRPS11 | 0.720116 | 3 | 0 | 3 |
| PSMC4 | VEGFB | 0.718672 | 3 | 0 | 3 |
| PSMC4 | EBNA1BP2 | 0.717368 | 3 | 0 | 3 |
| PSMC4 | SND1 | 0.711425 | 3 | 0 | 3 |
| PSMC4 | ACBD6 | 0.703196 | 5 | 0 | 5 |
| PSMC4 | ERCC8 | 0.696663 | 3 | 0 | 3 |
| PSMC4 | MRPL38 | 0.696 | 4 | 0 | 4 |
| PSMC4 | YIF1B | 0.693749 | 5 | 0 | 4 |
| PSMC4 | CHD7 | 0.69156 | 3 | 0 | 3 |
| PSMC4 | CAPRIN1 | 0.688996 | 4 | 0 | 3 |
| PSMC4 | PHF23 | 0.686001 | 4 | 0 | 3 |
For details and further investigation, click here
