| Full name: FXYD domain containing ion transport regulator 3 | Alias Symbol: MAT-8 | ||
| Type: protein-coding gene | Cytoband: 19q13.12 | ||
| Entrez ID: 5349 | HGNC ID: HGNC:4027 | Ensembl Gene: ENSG00000089356 | OMIM ID: 604996 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of FXYD3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FXYD3 | 5349 | 202489_s_at | 0.4281 | 0.4809 | |
| GSE20347 | FXYD3 | 5349 | 202489_s_at | -0.0877 | 0.8428 | |
| GSE23400 | FXYD3 | 5349 | 202489_s_at | 0.4055 | 0.0148 | |
| GSE26886 | FXYD3 | 5349 | 202489_s_at | 0.4028 | 0.0658 | |
| GSE29001 | FXYD3 | 5349 | 202489_s_at | 0.0782 | 0.8295 | |
| GSE38129 | FXYD3 | 5349 | 202489_s_at | 0.5214 | 0.3945 | |
| GSE45670 | FXYD3 | 5349 | 202489_s_at | 0.8121 | 0.0001 | |
| GSE53622 | FXYD3 | 5349 | 73830 | 0.4720 | 0.0388 | |
| GSE53624 | FXYD3 | 5349 | 73830 | 0.4363 | 0.0000 | |
| GSE63941 | FXYD3 | 5349 | 202489_s_at | 6.4908 | 0.0001 | |
| GSE77861 | FXYD3 | 5349 | 202489_s_at | 0.5956 | 0.0398 | |
| GSE97050 | FXYD3 | 5349 | A_33_P3228460 | 0.8613 | 0.3116 | |
| SRP007169 | FXYD3 | 5349 | RNAseq | -0.1289 | 0.8114 | |
| SRP008496 | FXYD3 | 5349 | RNAseq | -0.3472 | 0.3177 | |
| SRP064894 | FXYD3 | 5349 | RNAseq | 0.0100 | 0.9825 | |
| SRP133303 | FXYD3 | 5349 | RNAseq | 0.3827 | 0.2700 | |
| SRP159526 | FXYD3 | 5349 | RNAseq | 0.9812 | 0.0000 | |
| SRP193095 | FXYD3 | 5349 | RNAseq | 0.0439 | 0.8323 | |
| SRP219564 | FXYD3 | 5349 | RNAseq | -0.2108 | 0.8295 | |
| TCGA | FXYD3 | 5349 | RNAseq | 0.3229 | 0.0451 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by FXYD3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FXYD3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FXYD3 | 5349 | 6 | 4 | 20 | |
| GSE20123 | FXYD3 | 5349 | 6 | 3 | 21 | |
| GSE43470 | FXYD3 | 5349 | 4 | 7 | 32 | |
| GSE46452 | FXYD3 | 5349 | 48 | 1 | 10 | |
| GSE47630 | FXYD3 | 5349 | 9 | 5 | 26 | |
| GSE54993 | FXYD3 | 5349 | 17 | 3 | 50 | |
| GSE54994 | FXYD3 | 5349 | 9 | 9 | 35 | |
| GSE60625 | FXYD3 | 5349 | 9 | 0 | 2 | |
| GSE74703 | FXYD3 | 5349 | 4 | 4 | 28 | |
| GSE74704 | FXYD3 | 5349 | 6 | 1 | 13 | |
| TCGA | FXYD3 | 5349 | 21 | 11 | 64 |
Total number of gains: 139; Total number of losses: 48; Total Number of normals: 301.
Somatic mutations of FXYD3:
Generating mutation plots.
Highly correlated genes for FXYD3:
Showing top 20/500 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FXYD3 | ZBED1 | 0.767458 | 3 | 0 | 3 |
| FXYD3 | ZNF296 | 0.7382 | 3 | 0 | 3 |
| FXYD3 | S100A11 | 0.737939 | 5 | 0 | 4 |
| FXYD3 | MIA3 | 0.731859 | 3 | 0 | 3 |
| FXYD3 | CEP19 | 0.717736 | 3 | 0 | 3 |
| FXYD3 | IRF6 | 0.716972 | 8 | 0 | 7 |
| FXYD3 | ST14 | 0.714834 | 5 | 0 | 4 |
| FXYD3 | CDH1 | 0.705917 | 7 | 0 | 5 |
| FXYD3 | AP1S3 | 0.701393 | 3 | 0 | 3 |
| FXYD3 | DHPS | 0.698322 | 3 | 0 | 3 |
| FXYD3 | RASAL3 | 0.6978 | 3 | 0 | 3 |
| FXYD3 | F11R | 0.693842 | 10 | 0 | 8 |
| FXYD3 | HPS3 | 0.684505 | 3 | 0 | 3 |
| FXYD3 | TRIM29 | 0.682993 | 5 | 0 | 4 |
| FXYD3 | CHD1L | 0.682877 | 3 | 0 | 3 |
| FXYD3 | ZMYM3 | 0.681438 | 3 | 0 | 3 |
| FXYD3 | EXO1 | 0.675413 | 4 | 0 | 4 |
| FXYD3 | ZNF652 | 0.674643 | 3 | 0 | 3 |
| FXYD3 | SPINT2 | 0.67138 | 10 | 0 | 9 |
| FXYD3 | ULBP2 | 0.669535 | 3 | 0 | 3 |
For details and further investigation, click here
