FGF1

 

Full name: fibroblast growth factor 1 Alias Symbol: AFGF|ECGF|ECGFA|ECGFB|HBGF1|ECGF-beta|FGF-alpha|GLIO703
Type: protein-coding gene Cytoband: 5q31.3
Entrez ID: 2246 HGNC ID: HGNC:3665 Ensembl Gene: ENSG00000113578 OMIM ID: 131220
Drug and gene relationship at DGIdb

 

FGF1 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04390Hippo signaling pathway
hsa05200Pathways in cancer
hsa05218Melanoma

 

Expression of FGF1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FGF1 2246 205117_at -0.7973 0.1037
GSE20347 FGF1 2246 205117_at -0.0656 0.6377
GSE23400 FGF1 2246 205117_at -0.1181 0.0023
GSE26886 FGF1 2246 205117_at 0.3521 0.2785
GSE29001 FGF1 2246 205117_at 0.0158 0.9697
GSE38129 FGF1 2246 205117_at -0.2338 0.0672
GSE45670 FGF1 2246 205117_at -0.4087 0.0980
GSE53622 FGF1 2246 65231 0.0345 0.8227
GSE53624 FGF1 2246 54660 -0.4440 0.0031
GSE63941 FGF1 2246 205117_at -1.0714 0.0265
GSE77861 FGF1 2246 205117_at 0.0566 0.8260
GSE97050 FGF1 2246 A_23_P213336 0.7403 0.1163
SRP007169 FGF1 2246 RNAseq 1.7960 0.0029
SRP064894 FGF1 2246 RNAseq 0.3033 0.2621
SRP133303 FGF1 2246 RNAseq 0.0804 0.7774
SRP159526 FGF1 2246 RNAseq -0.2282 0.6720
SRP219564 FGF1 2246 RNAseq 0.6334 0.2431
TCGA FGF1 2246 RNAseq 0.1642 0.4572

Upregulated datasets: 1; Downregulated datasets: 1.  

 

Survival by FGF1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FGF1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FGF1 2246 1 12 17
GSE20123 FGF1 2246 1 12 17
GSE43470 FGF1 2246 2 10 31
GSE46452 FGF1 2246 0 27 32
GSE47630 FGF1 2246 0 20 20
GSE54993 FGF1 2246 9 1 60
GSE54994 FGF1 2246 2 14 37
GSE60625 FGF1 2246 0 0 11
GSE74703 FGF1 2246 2 7 27
GSE74704 FGF1 2246 1 6 13
TCGA FGF1 2246 3 38 55

Total number of gains: 21; Total number of losses: 147; Total Number of normals: 320.  

 

Somatic mutations of FGF1:

 

Generating mutation plots.

 

Highly correlated genes for FGF1:

 

Showing top 20/299 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FGF1RILP0.782022303
FGF1TNFRSF10D0.734492303
FGF1YBEY0.730168303
FGF1C1RL0.727956303
FGF1MBLAC10.698912303
FGF1CD440.69667303
FGF1SGMS20.686577303
FGF1CDH60.684019403
FGF1TMEM1580.679823403
FGF1RAB230.679106303
FGF1BMP20.677649303
FGF1EGR20.676169303
FGF1SESN10.675887303
FGF1RAB7B0.675763303
FGF1TLN20.675468303
FGF1LRP100.671996303
FGF1UBE4B0.670973404
FGF1CREB3L10.668965404
FGF1RBP50.666923303
FGF1NLGN4Y0.663772403

For details and further investigation, click here