| Full name: sestrin 1 | Alias Symbol: SEST1|PA26 | ||
| Type: protein-coding gene | Cytoband: 6q21 | ||
| Entrez ID: 27244 | HGNC ID: HGNC:21595 | Ensembl Gene: ENSG00000080546 | OMIM ID: 606103 |
| Drug and gene relationship at DGIdb | |||
SESN1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04115 | p53 signaling pathway | |
| hsa04211 | Longevity regulating pathway - mammal |
Expression of SESN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SESN1 | 27244 | 218346_s_at | -0.9272 | 0.1091 | |
| GSE20347 | SESN1 | 27244 | 218346_s_at | -0.6921 | 0.0004 | |
| GSE23400 | SESN1 | 27244 | 218346_s_at | -0.3417 | 0.0000 | |
| GSE26886 | SESN1 | 27244 | 218346_s_at | -1.0420 | 0.0004 | |
| GSE29001 | SESN1 | 27244 | 218346_s_at | -0.3236 | 0.1717 | |
| GSE38129 | SESN1 | 27244 | 218346_s_at | -0.7932 | 0.0000 | |
| GSE45670 | SESN1 | 27244 | 218346_s_at | -0.8210 | 0.0034 | |
| GSE53622 | SESN1 | 27244 | 47899 | -1.0080 | 0.0000 | |
| GSE53624 | SESN1 | 27244 | 47899 | -0.9991 | 0.0000 | |
| GSE63941 | SESN1 | 27244 | 218346_s_at | -1.3837 | 0.0024 | |
| GSE77861 | SESN1 | 27244 | 218346_s_at | -0.5612 | 0.0125 | |
| GSE97050 | SESN1 | 27244 | A_23_P93562 | -0.3169 | 0.2468 | |
| SRP007169 | SESN1 | 27244 | RNAseq | -0.9833 | 0.0089 | |
| SRP008496 | SESN1 | 27244 | RNAseq | -0.8672 | 0.0065 | |
| SRP064894 | SESN1 | 27244 | RNAseq | -0.5958 | 0.0230 | |
| SRP133303 | SESN1 | 27244 | RNAseq | -0.8403 | 0.0003 | |
| SRP159526 | SESN1 | 27244 | RNAseq | -1.0843 | 0.0010 | |
| SRP193095 | SESN1 | 27244 | RNAseq | -0.9750 | 0.0000 | |
| SRP219564 | SESN1 | 27244 | RNAseq | -0.4308 | 0.2451 | |
| TCGA | SESN1 | 27244 | RNAseq | -0.5427 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by SESN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SESN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SESN1 | 27244 | 3 | 3 | 24 | |
| GSE20123 | SESN1 | 27244 | 3 | 2 | 25 | |
| GSE43470 | SESN1 | 27244 | 3 | 1 | 39 | |
| GSE46452 | SESN1 | 27244 | 2 | 11 | 46 | |
| GSE47630 | SESN1 | 27244 | 9 | 4 | 27 | |
| GSE54993 | SESN1 | 27244 | 3 | 2 | 65 | |
| GSE54994 | SESN1 | 27244 | 9 | 8 | 36 | |
| GSE60625 | SESN1 | 27244 | 0 | 2 | 9 | |
| GSE74703 | SESN1 | 27244 | 2 | 1 | 33 | |
| GSE74704 | SESN1 | 27244 | 1 | 0 | 19 | |
| TCGA | SESN1 | 27244 | 6 | 24 | 66 |
Total number of gains: 41; Total number of losses: 58; Total Number of normals: 389.
Somatic mutations of SESN1:
Generating mutation plots.
Highly correlated genes for SESN1:
Showing top 20/1520 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SESN1 | ZMAT1 | 0.780207 | 4 | 0 | 4 |
| SESN1 | GGA3 | 0.761836 | 3 | 0 | 3 |
| SESN1 | SAT2 | 0.757842 | 3 | 0 | 3 |
| SESN1 | KPNA4 | 0.749033 | 3 | 0 | 3 |
| SESN1 | SGIP1 | 0.741026 | 3 | 0 | 3 |
| SESN1 | INMT | 0.735954 | 4 | 0 | 4 |
| SESN1 | PARD3B | 0.735052 | 5 | 0 | 5 |
| SESN1 | LRRK2 | 0.730274 | 8 | 0 | 7 |
| SESN1 | ST6GALNAC6 | 0.727914 | 5 | 0 | 5 |
| SESN1 | EIF4E3 | 0.723691 | 7 | 0 | 6 |
| SESN1 | KDM5D | 0.719786 | 4 | 0 | 4 |
| SESN1 | SLC44A3 | 0.718904 | 6 | 0 | 6 |
| SESN1 | RBM20 | 0.718196 | 5 | 0 | 5 |
| SESN1 | EVC2 | 0.716271 | 3 | 0 | 3 |
| SESN1 | ANAPC16 | 0.715922 | 4 | 0 | 3 |
| SESN1 | ZNF626 | 0.71512 | 5 | 0 | 5 |
| SESN1 | SLC4A4 | 0.712925 | 6 | 0 | 5 |
| SESN1 | CLMP | 0.710259 | 3 | 0 | 3 |
| SESN1 | ZFY | 0.705739 | 3 | 0 | 3 |
| SESN1 | FBXO8 | 0.702871 | 7 | 0 | 7 |
For details and further investigation, click here
