| Full name: fibroblast growth factor 18 | Alias Symbol: FGF-18|ZFGF5 | ||
| Type: protein-coding gene | Cytoband: 5q35.1 | ||
| Entrez ID: 8817 | HGNC ID: HGNC:3674 | Ensembl Gene: ENSG00000156427 | OMIM ID: 603726 |
| Drug and gene relationship at DGIdb | |||
FGF18 involved pathways:
Expression of FGF18:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FGF18 | 8817 | 211029_x_at | -0.2597 | 0.2928 | |
| GSE20347 | FGF18 | 8817 | 211485_s_at | -0.0445 | 0.5528 | |
| GSE23400 | FGF18 | 8817 | 211029_x_at | -0.0788 | 0.0240 | |
| GSE26886 | FGF18 | 8817 | 206986_at | 0.0579 | 0.7896 | |
| GSE29001 | FGF18 | 8817 | 214284_s_at | -0.3436 | 0.0453 | |
| GSE38129 | FGF18 | 8817 | 211485_s_at | -0.2229 | 0.0264 | |
| GSE45670 | FGF18 | 8817 | 206986_at | -0.1674 | 0.0993 | |
| GSE53622 | FGF18 | 8817 | 57237 | 0.5550 | 0.0000 | |
| GSE53624 | FGF18 | 8817 | 57237 | 0.2546 | 0.0125 | |
| GSE63941 | FGF18 | 8817 | 211485_s_at | 0.1338 | 0.4809 | |
| GSE77861 | FGF18 | 8817 | 211485_s_at | 0.0257 | 0.8310 | |
| GSE97050 | FGF18 | 8817 | A_23_P412389 | 0.5165 | 0.1788 | |
| SRP219564 | FGF18 | 8817 | RNAseq | 1.1617 | 0.2548 | |
| TCGA | FGF18 | 8817 | RNAseq | -1.4239 | 0.0006 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by FGF18 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FGF18:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FGF18 | 8817 | 1 | 13 | 16 | |
| GSE20123 | FGF18 | 8817 | 1 | 13 | 16 | |
| GSE43470 | FGF18 | 8817 | 1 | 11 | 31 | |
| GSE46452 | FGF18 | 8817 | 0 | 27 | 32 | |
| GSE47630 | FGF18 | 8817 | 0 | 20 | 20 | |
| GSE54993 | FGF18 | 8817 | 9 | 2 | 59 | |
| GSE54994 | FGF18 | 8817 | 2 | 15 | 36 | |
| GSE60625 | FGF18 | 8817 | 1 | 0 | 10 | |
| GSE74703 | FGF18 | 8817 | 1 | 7 | 28 | |
| GSE74704 | FGF18 | 8817 | 0 | 6 | 14 | |
| TCGA | FGF18 | 8817 | 9 | 35 | 52 |
Total number of gains: 25; Total number of losses: 149; Total Number of normals: 314.
Somatic mutations of FGF18:
Generating mutation plots.
Highly correlated genes for FGF18:
Showing top 20/549 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FGF18 | DOK7 | 0.807612 | 3 | 0 | 3 |
| FGF18 | ABCC2 | 0.751191 | 3 | 0 | 3 |
| FGF18 | PGC | 0.745597 | 3 | 0 | 3 |
| FGF18 | SYCE3 | 0.722823 | 3 | 0 | 3 |
| FGF18 | DCAF15 | 0.718322 | 3 | 0 | 3 |
| FGF18 | CNPY1 | 0.715391 | 3 | 0 | 3 |
| FGF18 | FMNL1 | 0.709709 | 4 | 0 | 4 |
| FGF18 | PLA2G4F | 0.701457 | 3 | 0 | 3 |
| FGF18 | C20orf85 | 0.7005 | 3 | 0 | 3 |
| FGF18 | ALPL | 0.690288 | 4 | 0 | 3 |
| FGF18 | D2HGDH | 0.68755 | 3 | 0 | 3 |
| FGF18 | TM4SF20 | 0.687345 | 4 | 0 | 4 |
| FGF18 | FKBP6 | 0.68621 | 4 | 0 | 3 |
| FGF18 | MOGAT3 | 0.685992 | 3 | 0 | 3 |
| FGF18 | SLC16A11 | 0.685342 | 4 | 0 | 3 |
| FGF18 | TRIM17 | 0.675469 | 5 | 0 | 4 |
| FGF18 | SSPO | 0.672823 | 3 | 0 | 3 |
| FGF18 | CHRNA2 | 0.672639 | 5 | 0 | 5 |
| FGF18 | ARL5C | 0.668506 | 3 | 0 | 3 |
| FGF18 | CELA3B | 0.667277 | 4 | 0 | 3 |
For details and further investigation, click here
