| Full name: fission, mitochondrial 1 | Alias Symbol: CGI-135|H_NH0132A01.6|Fis1 | ||
| Type: protein-coding gene | Cytoband: 7q22.1 | ||
| Entrez ID: 51024 | HGNC ID: HGNC:21689 | Ensembl Gene: ENSG00000214253 | OMIM ID: 609003 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of FIS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FIS1 | 51024 | 218034_at | -0.3239 | 0.4463 | |
| GSE20347 | FIS1 | 51024 | 218034_at | -0.2796 | 0.1911 | |
| GSE23400 | FIS1 | 51024 | 218034_at | -0.1076 | 0.2420 | |
| GSE26886 | FIS1 | 51024 | 218034_at | -0.0126 | 0.9714 | |
| GSE29001 | FIS1 | 51024 | 218034_at | -0.2306 | 0.6403 | |
| GSE38129 | FIS1 | 51024 | 218034_at | -0.2960 | 0.1091 | |
| GSE45670 | FIS1 | 51024 | 218034_at | -0.3685 | 0.0065 | |
| GSE53622 | FIS1 | 51024 | 135730 | -0.3792 | 0.0000 | |
| GSE53624 | FIS1 | 51024 | 135730 | -0.3069 | 0.0001 | |
| GSE63941 | FIS1 | 51024 | 218034_at | -0.7966 | 0.0578 | |
| GSE77861 | FIS1 | 51024 | 218034_at | -0.3102 | 0.1842 | |
| GSE97050 | FIS1 | 51024 | A_24_P277955 | -0.7417 | 0.1331 | |
| SRP007169 | FIS1 | 51024 | RNAseq | -1.1903 | 0.0005 | |
| SRP008496 | FIS1 | 51024 | RNAseq | -0.8004 | 0.0066 | |
| SRP064894 | FIS1 | 51024 | RNAseq | 0.2458 | 0.5326 | |
| SRP133303 | FIS1 | 51024 | RNAseq | -0.0963 | 0.6055 | |
| SRP159526 | FIS1 | 51024 | RNAseq | -0.3395 | 0.2473 | |
| SRP193095 | FIS1 | 51024 | RNAseq | -0.4291 | 0.0075 | |
| SRP219564 | FIS1 | 51024 | RNAseq | -0.2661 | 0.4436 | |
| TCGA | FIS1 | 51024 | RNAseq | -0.1163 | 0.0194 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by FIS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FIS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FIS1 | 51024 | 13 | 0 | 17 | |
| GSE20123 | FIS1 | 51024 | 13 | 0 | 17 | |
| GSE43470 | FIS1 | 51024 | 7 | 2 | 34 | |
| GSE46452 | FIS1 | 51024 | 11 | 1 | 47 | |
| GSE47630 | FIS1 | 51024 | 7 | 3 | 30 | |
| GSE54993 | FIS1 | 51024 | 1 | 10 | 59 | |
| GSE54994 | FIS1 | 51024 | 15 | 3 | 35 | |
| GSE60625 | FIS1 | 51024 | 0 | 0 | 11 | |
| GSE74703 | FIS1 | 51024 | 7 | 1 | 28 | |
| GSE74704 | FIS1 | 51024 | 9 | 0 | 11 | |
| TCGA | FIS1 | 51024 | 53 | 6 | 37 |
Total number of gains: 136; Total number of losses: 26; Total Number of normals: 326.
Somatic mutations of FIS1:
Generating mutation plots.
Highly correlated genes for FIS1:
Showing top 20/689 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FIS1 | ZNF862 | 0.816057 | 3 | 0 | 3 |
| FIS1 | DLG3 | 0.804971 | 3 | 0 | 3 |
| FIS1 | HIPK1 | 0.769442 | 3 | 0 | 3 |
| FIS1 | CDC26 | 0.76223 | 3 | 0 | 3 |
| FIS1 | GATAD1 | 0.748024 | 3 | 0 | 3 |
| FIS1 | ZFR | 0.744981 | 3 | 0 | 3 |
| FIS1 | NUB1 | 0.742533 | 3 | 0 | 3 |
| FIS1 | BRK1 | 0.7363 | 4 | 0 | 4 |
| FIS1 | SORT1 | 0.734798 | 4 | 0 | 3 |
| FIS1 | NUDT16 | 0.731326 | 4 | 0 | 3 |
| FIS1 | ARID2 | 0.727743 | 3 | 0 | 3 |
| FIS1 | COPS7A | 0.725331 | 4 | 0 | 4 |
| FIS1 | MYCN | 0.724186 | 3 | 0 | 3 |
| FIS1 | HLCS | 0.724153 | 3 | 0 | 3 |
| FIS1 | HNRNPAB | 0.721338 | 3 | 0 | 3 |
| FIS1 | ANTXR2 | 0.721291 | 3 | 0 | 3 |
| FIS1 | GMPPB | 0.719128 | 3 | 0 | 3 |
| FIS1 | SPATS2L | 0.717366 | 3 | 0 | 3 |
| FIS1 | GPRC5B | 0.702455 | 4 | 0 | 3 |
| FIS1 | NSRP1 | 0.702025 | 3 | 0 | 3 |
For details and further investigation, click here
