| Full name: holocarboxylase synthetase | Alias Symbol: HCS | ||
| Type: protein-coding gene | Cytoband: 21q22.13 | ||
| Entrez ID: 3141 | HGNC ID: HGNC:4976 | Ensembl Gene: ENSG00000159267 | OMIM ID: 609018 |
| Drug and gene relationship at DGIdb | |||
Expression of HLCS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HLCS | 3141 | 209399_at | 0.0692 | 0.8842 | |
| GSE20347 | HLCS | 3141 | 209399_at | -0.2078 | 0.0288 | |
| GSE23400 | HLCS | 3141 | 207833_s_at | -0.1634 | 0.0055 | |
| GSE26886 | HLCS | 3141 | 209399_at | 0.1195 | 0.5119 | |
| GSE29001 | HLCS | 3141 | 207833_s_at | -0.2525 | 0.3633 | |
| GSE38129 | HLCS | 3141 | 209399_at | -0.1923 | 0.0259 | |
| GSE45670 | HLCS | 3141 | 209399_at | -0.1505 | 0.2444 | |
| GSE53622 | HLCS | 3141 | 125186 | -0.1838 | 0.0198 | |
| GSE53624 | HLCS | 3141 | 72588 | -0.1759 | 0.0648 | |
| GSE63941 | HLCS | 3141 | 207833_s_at | 0.8401 | 0.1214 | |
| GSE77861 | HLCS | 3141 | 209399_at | -0.1111 | 0.4255 | |
| GSE97050 | HLCS | 3141 | A_23_P304991 | -0.3776 | 0.3379 | |
| SRP007169 | HLCS | 3141 | RNAseq | -2.1294 | 0.0000 | |
| SRP008496 | HLCS | 3141 | RNAseq | -1.1899 | 0.0005 | |
| SRP064894 | HLCS | 3141 | RNAseq | -1.0152 | 0.0000 | |
| SRP133303 | HLCS | 3141 | RNAseq | -0.7015 | 0.0000 | |
| SRP159526 | HLCS | 3141 | RNAseq | -0.3631 | 0.1961 | |
| SRP193095 | HLCS | 3141 | RNAseq | -0.5663 | 0.0000 | |
| SRP219564 | HLCS | 3141 | RNAseq | -0.9691 | 0.0649 | |
| TCGA | HLCS | 3141 | RNAseq | -0.1295 | 0.0203 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by HLCS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HLCS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HLCS | 3141 | 2 | 8 | 20 | |
| GSE20123 | HLCS | 3141 | 2 | 9 | 19 | |
| GSE43470 | HLCS | 3141 | 1 | 11 | 31 | |
| GSE46452 | HLCS | 3141 | 1 | 21 | 37 | |
| GSE47630 | HLCS | 3141 | 6 | 17 | 17 | |
| GSE54993 | HLCS | 3141 | 8 | 1 | 61 | |
| GSE54994 | HLCS | 3141 | 2 | 9 | 42 | |
| GSE60625 | HLCS | 3141 | 0 | 0 | 11 | |
| GSE74703 | HLCS | 3141 | 1 | 8 | 27 | |
| GSE74704 | HLCS | 3141 | 1 | 6 | 13 | |
| TCGA | HLCS | 3141 | 9 | 39 | 48 |
Total number of gains: 33; Total number of losses: 129; Total Number of normals: 326.
Somatic mutations of HLCS:
Generating mutation plots.
Highly correlated genes for HLCS:
Showing top 20/123 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HLCS | SLC24A1 | 0.753702 | 3 | 0 | 3 |
| HLCS | EXD2 | 0.73652 | 3 | 0 | 3 |
| HLCS | FIS1 | 0.724153 | 3 | 0 | 3 |
| HLCS | RRAGA | 0.707784 | 3 | 0 | 3 |
| HLCS | AGBL5 | 0.704939 | 3 | 0 | 3 |
| HLCS | NCOA2 | 0.702423 | 3 | 0 | 3 |
| HLCS | RAPGEF2 | 0.700427 | 3 | 0 | 3 |
| HLCS | INTS8 | 0.693615 | 3 | 0 | 3 |
| HLCS | CRIP1 | 0.687551 | 4 | 0 | 3 |
| HLCS | RSBN1 | 0.687218 | 3 | 0 | 3 |
| HLCS | ATP6V0E2 | 0.685287 | 3 | 0 | 3 |
| HLCS | KBTBD4 | 0.684371 | 3 | 0 | 3 |
| HLCS | TMEM25 | 0.68187 | 4 | 0 | 4 |
| HLCS | GTF3A | 0.673179 | 3 | 0 | 3 |
| HLCS | PEX2 | 0.669525 | 3 | 0 | 3 |
| HLCS | ZNF704 | 0.668095 | 4 | 0 | 3 |
| HLCS | EEFSEC | 0.66058 | 3 | 0 | 3 |
| HLCS | ACP6 | 0.657883 | 5 | 0 | 4 |
| HLCS | IRF2BP1 | 0.654399 | 3 | 0 | 3 |
| HLCS | KDM5C | 0.654121 | 3 | 0 | 3 |
For details and further investigation, click here
