FLT4

 

Full name: fms related tyrosine kinase 4 Alias Symbol: VEGFR3|PCL
Type: protein-coding gene Cytoband: 5q35.3
Entrez ID: 2324 HGNC ID: HGNC:3767 Ensembl Gene: ENSG00000037280 OMIM ID: 136352
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

FLT4 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04510Focal adhesion

 

Expression of FLT4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FLT4 2324 234379_at -0.0207 0.9467
GSE20347 FLT4 2324 210316_at 0.0588 0.4491
GSE23400 FLT4 2324 210316_at -0.0046 0.8451
GSE26886 FLT4 2324 234379_at 0.3305 0.0116
GSE29001 FLT4 2324 210316_at 0.0827 0.6122
GSE38129 FLT4 2324 210316_at 0.0216 0.8147
GSE45670 FLT4 2324 234379_at 0.0215 0.8206
GSE53622 FLT4 2324 56039 0.0081 0.9295
GSE53624 FLT4 2324 56039 -0.1675 0.0343
GSE63941 FLT4 2324 210316_at 0.3668 0.4561
GSE77861 FLT4 2324 234379_at -0.0001 0.9995
GSE97050 FLT4 2324 A_33_P3409269 0.3653 0.2433
SRP007169 FLT4 2324 RNAseq 2.5449 0.0027
SRP064894 FLT4 2324 RNAseq 0.4119 0.0912
SRP133303 FLT4 2324 RNAseq -0.2640 0.3631
SRP159526 FLT4 2324 RNAseq 0.6845 0.0661
SRP193095 FLT4 2324 RNAseq 0.5986 0.0110
SRP219564 FLT4 2324 RNAseq 0.2442 0.5376
TCGA FLT4 2324 RNAseq -0.2886 0.0135

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by FLT4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FLT4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FLT4 2324 2 13 15
GSE20123 FLT4 2324 2 13 15
GSE43470 FLT4 2324 1 10 32
GSE46452 FLT4 2324 0 27 32
GSE47630 FLT4 2324 1 20 19
GSE54993 FLT4 2324 10 2 58
GSE54994 FLT4 2324 3 18 32
GSE60625 FLT4 2324 1 0 10
GSE74703 FLT4 2324 1 6 29
GSE74704 FLT4 2324 1 6 13
TCGA FLT4 2324 12 34 50

Total number of gains: 34; Total number of losses: 149; Total Number of normals: 305.  

 

Somatic mutations of FLT4:

 

Generating mutation plots.

 

Highly correlated genes for FLT4:

 

Showing top 20/304 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FLT4SPRED30.749028303
FLT4GLI40.741893303
FLT4JAZF1-AS10.74169303
FLT4CD720.737392303
FLT4CCDC1540.732275404
FLT4SCT0.717186404
FLT4ACY10.711869505
FLT4ARSI0.707196303
FLT4KLF160.702124505
FLT4ACRBP0.694152303
FLT4KIR3DL20.692339303
FLT4SYT90.685537404
FLT4OST40.684186303
FLT4PYDC10.682073303
FLT4IGF20.677025303
FLT4PRR70.676604404
FLT4MAPRE30.675123303
FLT4RSPH90.674846504
FLT4RBBP8NL0.671165403
FLT4DIO3OS0.670823303

For details and further investigation, click here