| Full name: transmembrane serine protease 11E | Alias Symbol: DESC1 | ||
| Type: protein-coding gene | Cytoband: 4q13.2 | ||
| Entrez ID: 28983 | HGNC ID: HGNC:24465 | Ensembl Gene: ENSG00000087128 | OMIM ID: 610399 |
| Drug and gene relationship at DGIdb | |||
Expression of TMPRSS11E:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMPRSS11E | 28983 | 220431_at | -3.7426 | 0.1756 | |
| GSE20347 | TMPRSS11E | 28983 | 220431_at | -4.4179 | 0.0000 | |
| GSE23400 | TMPRSS11E | 28983 | 220431_at | -3.9360 | 0.0000 | |
| GSE26886 | TMPRSS11E | 28983 | 220431_at | -7.3590 | 0.0000 | |
| GSE29001 | TMPRSS11E | 28983 | 220431_at | -4.2725 | 0.0000 | |
| GSE38129 | TMPRSS11E | 28983 | 220431_at | -3.1030 | 0.0001 | |
| GSE45670 | TMPRSS11E | 28983 | 220431_at | -1.2930 | 0.0484 | |
| GSE53622 | TMPRSS11E | 28983 | 79920 | -3.3621 | 0.0000 | |
| GSE53624 | TMPRSS11E | 28983 | 79920 | -4.1682 | 0.0000 | |
| GSE63941 | TMPRSS11E | 28983 | 220431_at | 1.5026 | 0.3598 | |
| GSE77861 | TMPRSS11E | 28983 | 220431_at | -2.7336 | 0.0425 | |
| GSE97050 | TMPRSS11E | 28983 | A_23_P18751 | -0.7989 | 0.3828 | |
| SRP007169 | TMPRSS11E | 28983 | RNAseq | -5.6263 | 0.0000 | |
| SRP008496 | TMPRSS11E | 28983 | RNAseq | -5.9747 | 0.0000 | |
| SRP064894 | TMPRSS11E | 28983 | RNAseq | -4.4373 | 0.0000 | |
| SRP133303 | TMPRSS11E | 28983 | RNAseq | -4.1947 | 0.0000 | |
| SRP159526 | TMPRSS11E | 28983 | RNAseq | -4.5898 | 0.0000 | |
| SRP219564 | TMPRSS11E | 28983 | RNAseq | -4.8865 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 15.
Survival by TMPRSS11E expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of TMPRSS11E:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMPRSS11E | 28983 | 1 | 11 | 18 | |
| GSE20123 | TMPRSS11E | 28983 | 1 | 12 | 17 | |
| GSE43470 | TMPRSS11E | 28983 | 0 | 13 | 30 | |
| GSE46452 | TMPRSS11E | 28983 | 2 | 35 | 22 | |
| GSE47630 | TMPRSS11E | 28983 | 0 | 31 | 9 | |
| GSE54993 | TMPRSS11E | 28983 | 7 | 0 | 63 | |
| GSE54994 | TMPRSS11E | 28983 | 1 | 9 | 43 | |
| GSE60625 | TMPRSS11E | 28983 | 0 | 0 | 11 | |
| GSE74703 | TMPRSS11E | 28983 | 0 | 11 | 25 | |
| GSE74704 | TMPRSS11E | 28983 | 1 | 8 | 11 | |
| TCGA | TMPRSS11E | 28983 | 18 | 26 | 52 |
Total number of gains: 31; Total number of losses: 156; Total Number of normals: 301.
Somatic mutations of TMPRSS11E:
Generating mutation plots.
Highly correlated genes for TMPRSS11E:
Showing top 20/1410 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMPRSS11E | NCCRP1 | 0.920103 | 3 | 0 | 3 |
| TMPRSS11E | SCEL | 0.916733 | 12 | 0 | 12 |
| TMPRSS11E | CNFN | 0.913015 | 7 | 0 | 7 |
| TMPRSS11E | TMPRSS11B | 0.906338 | 7 | 0 | 7 |
| TMPRSS11E | TMPRSS11A | 0.906233 | 3 | 0 | 3 |
| TMPRSS11E | SPINK7 | 0.901422 | 7 | 0 | 7 |
| TMPRSS11E | CLIC3 | 0.891165 | 9 | 0 | 9 |
| TMPRSS11E | VSIG10L | 0.890335 | 7 | 0 | 7 |
| TMPRSS11E | KLK13 | 0.889898 | 11 | 0 | 11 |
| TMPRSS11E | CRNN | 0.88921 | 11 | 0 | 11 |
| TMPRSS11E | CLCA4 | 0.886601 | 12 | 0 | 12 |
| TMPRSS11E | A2ML1 | 0.885957 | 7 | 0 | 7 |
| TMPRSS11E | CSTB | 0.882891 | 11 | 0 | 11 |
| TMPRSS11E | CRCT1 | 0.882225 | 11 | 0 | 11 |
| TMPRSS11E | PRSS3 | 0.881789 | 11 | 0 | 11 |
| TMPRSS11E | CAPN14 | 0.879235 | 6 | 0 | 6 |
| TMPRSS11E | CEACAM7 | 0.877476 | 11 | 0 | 11 |
| TMPRSS11E | TGM3 | 0.872653 | 12 | 0 | 11 |
| TMPRSS11E | MXD1 | 0.872391 | 11 | 0 | 11 |
| TMPRSS11E | TGM1 | 0.872154 | 11 | 0 | 11 |
For details and further investigation, click here
