| Full name: formyl peptide receptor 1 | Alias Symbol: FPR|FMLP | ||
| Type: protein-coding gene | Cytoband: 19q13.41 | ||
| Entrez ID: 2357 | HGNC ID: HGNC:3826 | Ensembl Gene: ENSG00000171051 | OMIM ID: 136537 |
| Drug and gene relationship at DGIdb | |||
FPR1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04015 | Rap1 signaling pathway | |
| hsa05150 | Staphylococcus aureus infection |
Expression of FPR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FPR1 | 2357 | 205119_s_at | 1.3095 | 0.3660 | |
| GSE20347 | FPR1 | 2357 | 205119_s_at | 0.3621 | 0.0375 | |
| GSE23400 | FPR1 | 2357 | 205119_s_at | -0.0784 | 0.2646 | |
| GSE26886 | FPR1 | 2357 | 205119_s_at | 0.0286 | 0.9184 | |
| GSE29001 | FPR1 | 2357 | 205119_s_at | 0.2916 | 0.2721 | |
| GSE38129 | FPR1 | 2357 | 205119_s_at | 0.3883 | 0.0262 | |
| GSE45670 | FPR1 | 2357 | 205119_s_at | 0.3407 | 0.3771 | |
| GSE53622 | FPR1 | 2357 | 48325 | 0.1903 | 0.2362 | |
| GSE53624 | FPR1 | 2357 | 48325 | 0.3119 | 0.0996 | |
| GSE63941 | FPR1 | 2357 | 205119_s_at | 0.0875 | 0.6753 | |
| GSE77861 | FPR1 | 2357 | 205119_s_at | 0.3693 | 0.0505 | |
| GSE97050 | FPR1 | 2357 | A_23_P38795 | 0.0358 | 0.8914 | |
| SRP007169 | FPR1 | 2357 | RNAseq | 1.9289 | 0.0007 | |
| SRP008496 | FPR1 | 2357 | RNAseq | 1.6850 | 0.0001 | |
| SRP064894 | FPR1 | 2357 | RNAseq | 1.1232 | 0.0168 | |
| SRP133303 | FPR1 | 2357 | RNAseq | 1.6982 | 0.0000 | |
| SRP159526 | FPR1 | 2357 | RNAseq | 1.9449 | 0.0143 | |
| SRP193095 | FPR1 | 2357 | RNAseq | 2.5731 | 0.0000 | |
| SRP219564 | FPR1 | 2357 | RNAseq | 1.2697 | 0.1183 | |
| TCGA | FPR1 | 2357 | RNAseq | 0.0997 | 0.6178 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by FPR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FPR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FPR1 | 2357 | 3 | 4 | 23 | |
| GSE20123 | FPR1 | 2357 | 3 | 3 | 24 | |
| GSE43470 | FPR1 | 2357 | 3 | 12 | 28 | |
| GSE46452 | FPR1 | 2357 | 45 | 1 | 13 | |
| GSE47630 | FPR1 | 2357 | 10 | 6 | 24 | |
| GSE54993 | FPR1 | 2357 | 17 | 4 | 49 | |
| GSE54994 | FPR1 | 2357 | 4 | 14 | 35 | |
| GSE60625 | FPR1 | 2357 | 9 | 0 | 2 | |
| GSE74703 | FPR1 | 2357 | 3 | 8 | 25 | |
| GSE74704 | FPR1 | 2357 | 3 | 1 | 16 | |
| TCGA | FPR1 | 2357 | 14 | 20 | 62 |
Total number of gains: 114; Total number of losses: 73; Total Number of normals: 301.
Somatic mutations of FPR1:
Generating mutation plots.
Highly correlated genes for FPR1:
Showing top 20/117 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FPR1 | LAYN | 0.770209 | 3 | 0 | 3 |
| FPR1 | LRRC25 | 0.758219 | 3 | 0 | 3 |
| FPR1 | CMTM2 | 0.75126 | 4 | 0 | 4 |
| FPR1 | PGF | 0.750611 | 3 | 0 | 3 |
| FPR1 | FCGR3B | 0.717023 | 8 | 0 | 7 |
| FPR1 | NSUN6 | 0.715401 | 3 | 0 | 3 |
| FPR1 | SELL | 0.714718 | 9 | 0 | 9 |
| FPR1 | EPB41L4B | 0.693404 | 3 | 0 | 3 |
| FPR1 | TSR1 | 0.690836 | 4 | 0 | 3 |
| FPR1 | DHX34 | 0.685374 | 3 | 0 | 3 |
| FPR1 | MYO10 | 0.681598 | 3 | 0 | 3 |
| FPR1 | NCR3 | 0.670309 | 4 | 0 | 3 |
| FPR1 | FCRLB | 0.668616 | 3 | 0 | 3 |
| FPR1 | ALOX12B | 0.666742 | 3 | 0 | 3 |
| FPR1 | TREM1 | 0.655375 | 8 | 0 | 6 |
| FPR1 | AVL9 | 0.654338 | 3 | 0 | 3 |
| FPR1 | C6orf15 | 0.647982 | 3 | 0 | 3 |
| FPR1 | THEMIS2 | 0.645691 | 8 | 0 | 6 |
| FPR1 | SLA | 0.644794 | 9 | 0 | 8 |
| FPR1 | CD300LF | 0.643661 | 7 | 0 | 6 |
For details and further investigation, click here
