THEMIS2

 

Full name: thymocyte selection associated family member 2 Alias Symbol: ICB-1|Icb-1
Type: protein-coding gene Cytoband: 1p35.3
Entrez ID: 9473 HGNC ID: HGNC:16839 Ensembl Gene: ENSG00000130775 OMIM ID: 617856
Drug and gene relationship at DGIdb

 

Expression of THEMIS2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 THEMIS2 9473 207571_x_at 0.2358 0.8462
GSE20347 THEMIS2 9473 207571_x_at 0.1989 0.1899
GSE23400 THEMIS2 9473 207571_x_at 0.1678 0.0545
GSE26886 THEMIS2 9473 207571_x_at -0.2081 0.2575
GSE29001 THEMIS2 9473 207571_x_at 0.3823 0.1319
GSE38129 THEMIS2 9473 207571_x_at 0.2374 0.1451
GSE45670 THEMIS2 9473 207571_x_at 0.4747 0.0636
GSE53622 THEMIS2 9473 11249 0.3207 0.0037
GSE53624 THEMIS2 9473 11249 0.2690 0.0100
GSE63941 THEMIS2 9473 207571_x_at -1.1451 0.0145
GSE77861 THEMIS2 9473 207571_x_at 0.0796 0.6000
SRP007169 THEMIS2 9473 RNAseq 0.5179 0.3989
SRP008496 THEMIS2 9473 RNAseq 0.0702 0.8738
SRP064894 THEMIS2 9473 RNAseq 1.1747 0.0000
SRP133303 THEMIS2 9473 RNAseq 0.4874 0.0391
SRP159526 THEMIS2 9473 RNAseq -0.1884 0.7519
SRP193095 THEMIS2 9473 RNAseq 0.8762 0.0006
SRP219564 THEMIS2 9473 RNAseq 0.7248 0.2365

Upregulated datasets: 1; Downregulated datasets: 1.  

 

Survival by THEMIS2 expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  

Copy number change of THEMIS2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 THEMIS2 9473 0 6 24
GSE20123 THEMIS2 9473 0 5 25
GSE43470 THEMIS2 9473 3 6 34
GSE46452 THEMIS2 9473 5 1 53
GSE47630 THEMIS2 9473 8 3 29
GSE54993 THEMIS2 9473 2 1 67
GSE54994 THEMIS2 9473 10 4 39
GSE60625 THEMIS2 9473 0 0 11
GSE74703 THEMIS2 9473 2 4 30
GSE74704 THEMIS2 9473 0 0 20
TCGA THEMIS2 9473 11 23 62

Total number of gains: 41; Total number of losses: 53; Total Number of normals: 394.  

 

Somatic mutations of THEMIS2:

 

Generating mutation plots.

 

Highly correlated genes for THEMIS2:

 

Showing top 20/263 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
THEMIS2PIK3AP10.761388303
THEMIS2MFNG0.707721403
THEMIS2GMFG0.698127807
THEMIS2IL2RB0.696634606
THEMIS2PIK3R50.692957403
THEMIS2RASAL30.690317303
THEMIS2SLA0.689914807
THEMIS2IL10RA0.679921807
THEMIS2TNFRSF1B0.6798451109
THEMIS2SAMSN10.67424807
THEMIS2LAPTM50.66576907
THEMIS2LCP20.663428907
THEMIS2EVI2B0.662449806
THEMIS2SUCNR10.662317303
THEMIS2CD370.6578706
THEMIS2TMEM1190.65277403
THEMIS2HLA-DMB0.652143707
THEMIS2FCN10.65207404
THEMIS2SIGLEC100.651691504
THEMIS2CCR10.65085908

For details and further investigation, click here