FZD2

 

Full name: frizzled class receptor 2 Alias Symbol: 
Type: protein-coding gene Cytoband: 17q21.31
Entrez ID: 2535 HGNC ID: HGNC:4040 Ensembl Gene: ENSG00000180340 OMIM ID: 600667
Drug and gene relationship at DGIdb

 

FZD2 involved pathways:

KEGG pathway Description View
hsa04150mTOR signaling pathway
hsa04310Wnt signaling pathway
hsa04390Hippo signaling pathway
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04916Melanogenesis
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05217Basal cell carcinoma

 

Expression of FZD2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FZD2 2535 238129_s_at 0.3105 0.2458
GSE20347 FZD2 2535 210220_at 1.2618 0.0000
GSE23400 FZD2 2535 210220_at 0.4572 0.0000
GSE26886 FZD2 2535 238129_s_at 0.1830 0.0941
GSE29001 FZD2 2535 210220_at 1.3892 0.0081
GSE38129 FZD2 2535 210220_at 1.3103 0.0000
GSE45670 FZD2 2535 210220_at 0.8613 0.0077
GSE53622 FZD2 2535 50016 1.4897 0.0000
GSE53624 FZD2 2535 50016 1.8208 0.0000
GSE63941 FZD2 2535 210220_at -0.9716 0.2378
GSE77861 FZD2 2535 238129_s_at 0.1431 0.1523
GSE97050 FZD2 2535 A_23_P141362 0.5131 0.1889
SRP007169 FZD2 2535 RNAseq 2.7475 0.0021
SRP008496 FZD2 2535 RNAseq 1.9098 0.0011
SRP064894 FZD2 2535 RNAseq 1.9682 0.0000
SRP133303 FZD2 2535 RNAseq 0.9453 0.0000
SRP159526 FZD2 2535 RNAseq 1.6912 0.0038
SRP219564 FZD2 2535 RNAseq 1.4224 0.0059
TCGA FZD2 2535 RNAseq 1.2044 0.0000

Upregulated datasets: 11; Downregulated datasets: 0.  

 

Survival by FZD2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FZD2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FZD2 2535 5 2 23
GSE20123 FZD2 2535 5 2 23
GSE43470 FZD2 2535 1 2 40
GSE46452 FZD2 2535 32 0 27
GSE47630 FZD2 2535 9 0 31
GSE54993 FZD2 2535 3 4 63
GSE54994 FZD2 2535 8 5 40
GSE60625 FZD2 2535 4 0 7
GSE74703 FZD2 2535 1 1 34
GSE74704 FZD2 2535 3 1 16
TCGA FZD2 2535 24 7 65

Total number of gains: 95; Total number of losses: 24; Total Number of normals: 369.  

 

Somatic mutations of FZD2:

 

Generating mutation plots.

 

Highly correlated genes for FZD2:

 

Showing top 20/1652 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FZD2SPON20.820794303
FZD2RAB340.809208303
FZD2SHISA20.772811505
FZD2GNG100.768779303
FZD2PYCR20.762725303
FZD2FCGR3A0.761876303
FZD2CEP1700.761629303
FZD2PDIA50.736675303
FZD2TMEM2140.735656303
FZD2MMS22L0.728594303
FZD2LRRC8C0.727096303
FZD2GORAB0.721314505
FZD2PLOD10.71556810010
FZD2SERPINH10.7104761009
FZD2MAD2L20.709921403
FZD2GPX80.707577504
FZD2STARD3NL0.705816303
FZD2CAD0.70474511010
FZD2SCNM10.704037303
FZD2IL2RA0.70079404

For details and further investigation, click here