| Full name: pyruvate dehydrogenase phosphatase regulatory subunit | Alias Symbol: PDP3 | ||
| Type: protein-coding gene | Cytoband: 16q22.1 | ||
| Entrez ID: 55066 | HGNC ID: HGNC:30264 | Ensembl Gene: ENSG00000090857 | OMIM ID: 617835 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PDPR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDPR | 55066 | 224902_at | 0.4840 | 0.4279 | |
| GSE20347 | PDPR | 55066 | 220236_at | 0.1521 | 0.1381 | |
| GSE23400 | PDPR | 55066 | 220236_at | -0.0435 | 0.3062 | |
| GSE26886 | PDPR | 55066 | 224904_at | 0.8875 | 0.0006 | |
| GSE29001 | PDPR | 55066 | 220236_at | 0.0915 | 0.6295 | |
| GSE38129 | PDPR | 55066 | 220236_at | 0.1134 | 0.1731 | |
| GSE45670 | PDPR | 55066 | 224904_at | 0.0534 | 0.8590 | |
| GSE53622 | PDPR | 55066 | 59676 | 0.4619 | 0.0000 | |
| GSE53624 | PDPR | 55066 | 59676 | 0.4732 | 0.0000 | |
| GSE63941 | PDPR | 55066 | 224904_at | -0.4782 | 0.3770 | |
| GSE77861 | PDPR | 55066 | 224902_at | 1.1125 | 0.0569 | |
| GSE97050 | PDPR | 55066 | A_33_P3319113 | 0.2348 | 0.2689 | |
| SRP007169 | PDPR | 55066 | RNAseq | 1.1219 | 0.0391 | |
| SRP008496 | PDPR | 55066 | RNAseq | 1.1588 | 0.0082 | |
| SRP064894 | PDPR | 55066 | RNAseq | 0.3727 | 0.1058 | |
| SRP133303 | PDPR | 55066 | RNAseq | 0.2248 | 0.3178 | |
| SRP159526 | PDPR | 55066 | RNAseq | 0.2664 | 0.4135 | |
| SRP193095 | PDPR | 55066 | RNAseq | 0.6281 | 0.0000 | |
| SRP219564 | PDPR | 55066 | RNAseq | -0.2774 | 0.4098 | |
| TCGA | PDPR | 55066 | RNAseq | -0.1155 | 0.0969 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by PDPR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDPR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDPR | 55066 | 6 | 1 | 23 | |
| GSE20123 | PDPR | 55066 | 6 | 1 | 23 | |
| GSE43470 | PDPR | 55066 | 2 | 8 | 33 | |
| GSE46452 | PDPR | 55066 | 38 | 1 | 20 | |
| GSE47630 | PDPR | 55066 | 11 | 8 | 21 | |
| GSE54993 | PDPR | 55066 | 2 | 4 | 64 | |
| GSE54994 | PDPR | 55066 | 8 | 10 | 35 | |
| GSE60625 | PDPR | 55066 | 4 | 0 | 7 | |
| GSE74703 | PDPR | 55066 | 2 | 5 | 29 | |
| GSE74704 | PDPR | 55066 | 3 | 0 | 17 | |
| TCGA | PDPR | 55066 | 28 | 12 | 56 |
Total number of gains: 110; Total number of losses: 50; Total Number of normals: 328.
Somatic mutations of PDPR:
Generating mutation plots.
Highly correlated genes for PDPR:
Showing top 20/731 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDPR | AKR1B1 | 0.814182 | 3 | 0 | 3 |
| PDPR | SRBD1 | 0.808725 | 3 | 0 | 3 |
| PDPR | CPSF3 | 0.808672 | 4 | 0 | 4 |
| PDPR | MRPL11 | 0.807583 | 3 | 0 | 3 |
| PDPR | PHF5A | 0.784802 | 3 | 0 | 3 |
| PDPR | BCL7C | 0.780434 | 3 | 0 | 3 |
| PDPR | ZNF319 | 0.78025 | 3 | 0 | 3 |
| PDPR | ABCF2 | 0.763313 | 3 | 0 | 3 |
| PDPR | TRAF7 | 0.758903 | 4 | 0 | 4 |
| PDPR | POLR2G | 0.754611 | 4 | 0 | 4 |
| PDPR | RAN | 0.75449 | 3 | 0 | 3 |
| PDPR | LCLAT1 | 0.754094 | 5 | 0 | 5 |
| PDPR | SAMM50 | 0.753753 | 3 | 0 | 3 |
| PDPR | MRPL47 | 0.751302 | 4 | 0 | 4 |
| PDPR | IFNGR1 | 0.75119 | 3 | 0 | 3 |
| PDPR | THAP10 | 0.748 | 3 | 0 | 3 |
| PDPR | BAD | 0.747856 | 3 | 0 | 3 |
| PDPR | OLA1 | 0.742647 | 3 | 0 | 3 |
| PDPR | JKAMP | 0.741605 | 3 | 0 | 3 |
| PDPR | DCTPP1 | 0.741102 | 3 | 0 | 3 |
For details and further investigation, click here
