GAB1

 

Full name: GRB2 associated binding protein 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 4q31.21
Entrez ID: 2549 HGNC ID: HGNC:4066 Ensembl Gene: ENSG00000109458 OMIM ID: 604439
Drug and gene relationship at DGIdb
Screen Evidence:

 

GAB1 involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04722Neurotrophin signaling pathway
hsa05100Bacterial invasion of epithelial cells
hsa05205Proteoglycans in cancer
hsa05211Renal cell carcinoma

 

Expression of GAB1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GAB1 2549 226002_at -1.6194 0.0137
GSE20347 GAB1 2549 214987_at -0.5547 0.0000
GSE23400 GAB1 2549 214987_at -0.1780 0.0000
GSE26886 GAB1 2549 229114_at -2.0484 0.0000
GSE29001 GAB1 2549 214987_at -0.8940 0.0023
GSE38129 GAB1 2549 214987_at -0.8239 0.0000
GSE45670 GAB1 2549 225998_at -0.7508 0.0031
GSE53622 GAB1 2549 55835 -1.4087 0.0000
GSE53624 GAB1 2549 55835 -1.3587 0.0000
GSE63941 GAB1 2549 225998_at -0.8801 0.0245
GSE77861 GAB1 2549 225998_at -1.2018 0.0004
GSE97050 GAB1 2549 A_23_P335239 -1.5895 0.0826
SRP007169 GAB1 2549 RNAseq -1.9439 0.0000
SRP008496 GAB1 2549 RNAseq -1.4498 0.0000
SRP064894 GAB1 2549 RNAseq -1.2910 0.0000
SRP133303 GAB1 2549 RNAseq -1.0774 0.0000
SRP159526 GAB1 2549 RNAseq -1.4511 0.0000
SRP193095 GAB1 2549 RNAseq -1.2503 0.0000
SRP219564 GAB1 2549 RNAseq -1.0809 0.0621
TCGA GAB1 2549 RNAseq -0.2889 0.0001

Upregulated datasets: 0; Downregulated datasets: 11.  

 

Survival by GAB1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GAB1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GAB1 2549 0 12 18
GSE20123 GAB1 2549 0 12 18
GSE43470 GAB1 2549 2 11 30
GSE46452 GAB1 2549 1 36 22
GSE47630 GAB1 2549 0 22 18
GSE54993 GAB1 2549 10 0 60
GSE54994 GAB1 2549 2 11 40
GSE60625 GAB1 2549 0 1 10
GSE74703 GAB1 2549 1 10 25
GSE74704 GAB1 2549 0 6 14
TCGA GAB1 2549 14 31 51

Total number of gains: 30; Total number of losses: 152; Total Number of normals: 306.  

 

Somatic mutations of GAB1:

 

Generating mutation plots.

 

Highly correlated genes for GAB1:

 

Showing top 20/1867 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GAB1SLMAP0.774646707
GAB1RHOJ0.774266303
GAB1SLC25A30.768275303
GAB1EIF4E30.764967706
GAB1SH3BGRL20.764596707
GAB1SLC25A510.763746303
GAB1FCHO20.762764807
GAB1MMRN10.753973404
GAB1KDM5D0.753302303
GAB1FAM214A0.749468606
GAB1KRT780.745358606
GAB1FIBIN0.743324303
GAB1SPAG170.74123404
GAB1ACADM0.740415909
GAB1TCEAL10.739634404
GAB1CAB39L0.73929111010
GAB1RNF1410.738185909
GAB1COMMD10.737051504
GAB1ZNF667-AS10.736974303
GAB1IK0.734899808

For details and further investigation, click here