| Full name: C-X-C motif chemokine receptor 6 | Alias Symbol: TYMSTR|STRL33|BONZO|CD186 | ||
| Type: protein-coding gene | Cytoband: 3p21.31 | ||
| Entrez ID: 10663 | HGNC ID: HGNC:16647 | Ensembl Gene: ENSG00000172215 | OMIM ID: 605163 |
| Drug and gene relationship at DGIdb | |||
CXCR6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway |
Expression of CXCR6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CXCR6 | 10663 | 211469_s_at | 0.0921 | 0.8636 | |
| GSE20347 | CXCR6 | 10663 | 211469_s_at | -0.0346 | 0.7035 | |
| GSE23400 | CXCR6 | 10663 | 211469_s_at | -0.1016 | 0.0056 | |
| GSE26886 | CXCR6 | 10663 | 206974_at | -0.8081 | 0.0198 | |
| GSE29001 | CXCR6 | 10663 | 211469_s_at | -0.2994 | 0.0334 | |
| GSE38129 | CXCR6 | 10663 | 206974_at | -0.0800 | 0.5130 | |
| GSE45670 | CXCR6 | 10663 | 206974_at | 0.0985 | 0.6973 | |
| GSE63941 | CXCR6 | 10663 | 211469_s_at | 0.3395 | 0.0349 | |
| GSE77861 | CXCR6 | 10663 | 211469_s_at | -0.0343 | 0.7124 | |
| GSE97050 | CXCR6 | 10663 | A_23_P109913 | 0.5081 | 0.2712 | |
| SRP007169 | CXCR6 | 10663 | RNAseq | -0.7432 | 0.2978 | |
| SRP064894 | CXCR6 | 10663 | RNAseq | -0.5070 | 0.1004 | |
| SRP133303 | CXCR6 | 10663 | RNAseq | -0.4227 | 0.0990 | |
| SRP159526 | CXCR6 | 10663 | RNAseq | -1.0701 | 0.1882 | |
| SRP193095 | CXCR6 | 10663 | RNAseq | -0.6210 | 0.0035 | |
| SRP219564 | CXCR6 | 10663 | RNAseq | 0.4453 | 0.4436 | |
| TCGA | CXCR6 | 10663 | RNAseq | -0.0032 | 0.9886 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CXCR6 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CXCR6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CXCR6 | 10663 | 0 | 17 | 13 | |
| GSE20123 | CXCR6 | 10663 | 0 | 18 | 12 | |
| GSE43470 | CXCR6 | 10663 | 0 | 20 | 23 | |
| GSE46452 | CXCR6 | 10663 | 2 | 17 | 40 | |
| GSE47630 | CXCR6 | 10663 | 2 | 23 | 15 | |
| GSE54993 | CXCR6 | 10663 | 7 | 2 | 61 | |
| GSE54994 | CXCR6 | 10663 | 0 | 36 | 17 | |
| GSE60625 | CXCR6 | 10663 | 5 | 0 | 6 | |
| GSE74703 | CXCR6 | 10663 | 0 | 15 | 21 | |
| GSE74704 | CXCR6 | 10663 | 0 | 12 | 8 | |
| TCGA | CXCR6 | 10663 | 1 | 75 | 20 |
Total number of gains: 17; Total number of losses: 235; Total Number of normals: 236.
Somatic mutations of CXCR6:
Generating mutation plots.
Highly correlated genes for CXCR6:
Showing top 20/252 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CXCR6 | FGF6 | 0.75163 | 3 | 0 | 3 |
| CXCR6 | C8A | 0.726993 | 3 | 0 | 3 |
| CXCR6 | CEACAM21 | 0.718037 | 4 | 0 | 3 |
| CXCR6 | GABRD | 0.705273 | 3 | 0 | 3 |
| CXCR6 | HCST | 0.701313 | 4 | 0 | 4 |
| CXCR6 | TSPO2 | 0.700715 | 3 | 0 | 3 |
| CXCR6 | NFE2 | 0.695795 | 3 | 0 | 3 |
| CXCR6 | CYTIP | 0.694892 | 5 | 0 | 5 |
| CXCR6 | HPSE2 | 0.692361 | 3 | 0 | 3 |
| CXCR6 | CETP | 0.690889 | 5 | 0 | 5 |
| CXCR6 | TNFAIP8L2 | 0.690719 | 3 | 0 | 3 |
| CXCR6 | NDOR1 | 0.680948 | 3 | 0 | 3 |
| CXCR6 | NLRC3 | 0.673227 | 4 | 0 | 3 |
| CXCR6 | GK | 0.671871 | 4 | 0 | 4 |
| CXCR6 | ACAP1 | 0.671388 | 3 | 0 | 3 |
| CXCR6 | TRG-AS1 | 0.668818 | 4 | 0 | 4 |
| CXCR6 | FCER2 | 0.664763 | 4 | 0 | 4 |
| CXCR6 | IL2RG | 0.662147 | 7 | 0 | 6 |
| CXCR6 | CAMP | 0.656343 | 3 | 0 | 3 |
| CXCR6 | LCP2 | 0.655888 | 5 | 0 | 5 |
For details and further investigation, click here
