| Full name: cytokine inducible SH2 containing protein | Alias Symbol: CIS|G18|CIS-1|SOCS | ||
| Type: protein-coding gene | Cytoband: 3p21.2 | ||
| Entrez ID: 1154 | HGNC ID: HGNC:1984 | Ensembl Gene: ENSG00000114737 | OMIM ID: 602441 |
| Drug and gene relationship at DGIdb | |||
CISH involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway | |
| hsa04917 | Prolactin signaling pathway |
Expression of CISH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CISH | 1154 | 221223_x_at | -0.1083 | 0.7993 | |
| GSE20347 | CISH | 1154 | 221223_x_at | -0.1977 | 0.0740 | |
| GSE23400 | CISH | 1154 | 221223_x_at | -0.1482 | 0.0011 | |
| GSE26886 | CISH | 1154 | 221223_x_at | -0.4844 | 0.0002 | |
| GSE29001 | CISH | 1154 | 221223_x_at | -0.2310 | 0.1953 | |
| GSE38129 | CISH | 1154 | 221223_x_at | -0.3191 | 0.0053 | |
| GSE45670 | CISH | 1154 | 223377_x_at | -0.1826 | 0.2166 | |
| GSE53622 | CISH | 1154 | 15882 | -0.7311 | 0.0000 | |
| GSE53624 | CISH | 1154 | 15882 | -0.6882 | 0.0000 | |
| GSE63941 | CISH | 1154 | 223377_x_at | 0.3082 | 0.2502 | |
| GSE77861 | CISH | 1154 | 221223_x_at | -0.2923 | 0.0202 | |
| GSE97050 | CISH | 1154 | A_23_P144096 | -0.1325 | 0.5797 | |
| SRP007169 | CISH | 1154 | RNAseq | -0.8354 | 0.1485 | |
| SRP008496 | CISH | 1154 | RNAseq | -0.8781 | 0.0130 | |
| SRP064894 | CISH | 1154 | RNAseq | -0.1895 | 0.3655 | |
| SRP133303 | CISH | 1154 | RNAseq | -0.1569 | 0.3002 | |
| SRP159526 | CISH | 1154 | RNAseq | -1.1376 | 0.0035 | |
| SRP193095 | CISH | 1154 | RNAseq | -0.9095 | 0.0000 | |
| SRP219564 | CISH | 1154 | RNAseq | -0.3612 | 0.3977 | |
| TCGA | CISH | 1154 | RNAseq | -0.3241 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CISH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CISH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CISH | 1154 | 0 | 18 | 12 | |
| GSE20123 | CISH | 1154 | 0 | 19 | 11 | |
| GSE43470 | CISH | 1154 | 0 | 19 | 24 | |
| GSE46452 | CISH | 1154 | 2 | 16 | 41 | |
| GSE47630 | CISH | 1154 | 1 | 24 | 15 | |
| GSE54993 | CISH | 1154 | 6 | 2 | 62 | |
| GSE54994 | CISH | 1154 | 0 | 34 | 19 | |
| GSE60625 | CISH | 1154 | 5 | 0 | 6 | |
| GSE74703 | CISH | 1154 | 0 | 15 | 21 | |
| GSE74704 | CISH | 1154 | 0 | 12 | 8 | |
| TCGA | CISH | 1154 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 237; Total Number of normals: 237.
Somatic mutations of CISH:
Generating mutation plots.
Highly correlated genes for CISH:
Showing top 20/876 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CISH | LGI2 | 0.799884 | 3 | 0 | 3 |
| CISH | CNTF | 0.789901 | 3 | 0 | 3 |
| CISH | KRTAP4-3 | 0.787409 | 3 | 0 | 3 |
| CISH | GABRR2 | 0.73271 | 4 | 0 | 4 |
| CISH | RHOBTB2 | 0.729832 | 3 | 0 | 3 |
| CISH | TP53RK | 0.718808 | 3 | 0 | 3 |
| CISH | KCNC4 | 0.718406 | 5 | 0 | 4 |
| CISH | TTN | 0.715337 | 5 | 0 | 5 |
| CISH | SHB | 0.70534 | 3 | 0 | 3 |
| CISH | SACS-AS1 | 0.703991 | 3 | 0 | 3 |
| CISH | ZCCHC10 | 0.703975 | 3 | 0 | 3 |
| CISH | HFE | 0.697837 | 4 | 0 | 4 |
| CISH | FRAS1 | 0.695684 | 4 | 0 | 4 |
| CISH | FLII | 0.687833 | 3 | 0 | 3 |
| CISH | CXCR1 | 0.683935 | 6 | 0 | 6 |
| CISH | REEP2 | 0.683161 | 5 | 0 | 4 |
| CISH | ATP1A4 | 0.682771 | 3 | 0 | 3 |
| CISH | TSHR | 0.676658 | 4 | 0 | 4 |
| CISH | SCGB1D1 | 0.674303 | 3 | 0 | 3 |
| CISH | HHLA1 | 0.673238 | 6 | 0 | 6 |
For details and further investigation, click here
