TPI1

 

Full name: triosephosphate isomerase 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 12p13.31
Entrez ID: 7167 HGNC ID: HGNC:12009 Ensembl Gene: ENSG00000111669 OMIM ID: 190450
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of TPI1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TPI1 7167 213011_s_at 0.1717 0.7346
GSE20347 TPI1 7167 213011_s_at 0.0656 0.7317
GSE23400 TPI1 7167 200822_x_at 0.2399 0.0005
GSE26886 TPI1 7167 213011_s_at -0.1276 0.5677
GSE29001 TPI1 7167 213011_s_at -0.0155 0.9685
GSE38129 TPI1 7167 213011_s_at 0.2264 0.0720
GSE45670 TPI1 7167 213011_s_at 0.2526 0.2489
GSE53622 TPI1 7167 70149 0.1164 0.3129
GSE53624 TPI1 7167 70149 0.4017 0.0000
GSE63941 TPI1 7167 213011_s_at 0.6575 0.1356
GSE77861 TPI1 7167 213011_s_at 0.1877 0.4263
GSE97050 TPI1 A_21_P0000534 0.1181 0.6921
SRP007169 TPI1 7167 RNAseq -0.5305 0.1943
SRP008496 TPI1 7167 RNAseq -0.4136 0.0753
SRP064894 TPI1 7167 RNAseq 0.0217 0.9288
SRP133303 TPI1 7167 RNAseq 0.5609 0.0182
SRP159526 TPI1 7167 RNAseq 0.2210 0.4269
SRP193095 TPI1 7167 RNAseq -0.1524 0.3823
SRP219564 TPI1 7167 RNAseq -0.0942 0.7858
TCGA TPI1 7167 RNAseq 0.2178 0.0000

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by TPI1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TPI1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TPI1 7167 9 3 18
GSE20123 TPI1 7167 9 3 18
GSE43470 TPI1 7167 8 3 32
GSE46452 TPI1 7167 10 1 48
GSE47630 TPI1 7167 12 2 26
GSE54993 TPI1 7167 1 10 59
GSE54994 TPI1 7167 10 2 41
GSE60625 TPI1 7167 0 1 10
GSE74703 TPI1 7167 7 2 27
GSE74704 TPI1 7167 5 3 12
TCGA TPI1 7167 40 6 50

Total number of gains: 111; Total number of losses: 36; Total Number of normals: 341.  

 

Somatic mutations of TPI1:

 

Generating mutation plots.

 

Highly correlated genes for TPI1:

 

Showing top 20/377 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TPI1GAPDH0.74672511010
TPI1RAB11B0.721513303
TPI1LRRC410.689307403
TPI1CDKAL10.688473403
TPI1TNFRSF1A0.67717505
TPI1COG50.661092303
TPI1MLF20.65669912010
TPI1EMG10.6566511010
TPI1C15orf390.650781403
TPI1CYB5B0.650366504
TPI1CCDC770.648362505
TPI1DUS3L0.646805303
TPI1KDELR20.643083606
TPI1POLR3C0.639061403
TPI1DUSP160.63494403
TPI1UBE2M0.632347504
TPI1FPGS0.62448303
TPI1MRPL510.624256906
TPI1TLK20.622544403
TPI1C8orf760.619344303

For details and further investigation, click here