| Full name: growth arrest specific 8 | Alias Symbol: DRC4 | ||
| Type: protein-coding gene | Cytoband: 16q24.3 | ||
| Entrez ID: 2622 | HGNC ID: HGNC:4166 | Ensembl Gene: ENSG00000141013 | OMIM ID: 605178 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of GAS8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GAS8 | 2622 | 204921_at | -0.3375 | 0.2165 | |
| GSE20347 | GAS8 | 2622 | 204921_at | -0.2170 | 0.0142 | |
| GSE23400 | GAS8 | 2622 | 204921_at | -0.3401 | 0.0000 | |
| GSE26886 | GAS8 | 2622 | 204921_at | -0.4442 | 0.0049 | |
| GSE29001 | GAS8 | 2622 | 204921_at | -0.4120 | 0.0109 | |
| GSE38129 | GAS8 | 2622 | 204921_at | -0.2691 | 0.0047 | |
| GSE45670 | GAS8 | 2622 | 204921_at | -0.0813 | 0.4997 | |
| GSE53622 | GAS8 | 2622 | 49392 | -0.2599 | 0.0000 | |
| GSE53624 | GAS8 | 2622 | 63347 | -0.4991 | 0.0000 | |
| GSE63941 | GAS8 | 2622 | 204921_at | 0.3879 | 0.0956 | |
| GSE77861 | GAS8 | 2622 | 204921_at | -0.2252 | 0.0383 | |
| GSE97050 | GAS8 | 2622 | A_33_P3405921 | -0.1165 | 0.6191 | |
| SRP007169 | GAS8 | 2622 | RNAseq | -0.6018 | 0.1867 | |
| SRP064894 | GAS8 | 2622 | RNAseq | -0.4894 | 0.0117 | |
| SRP133303 | GAS8 | 2622 | RNAseq | -0.4187 | 0.0054 | |
| SRP159526 | GAS8 | 2622 | RNAseq | -0.1173 | 0.5961 | |
| SRP193095 | GAS8 | 2622 | RNAseq | 0.1428 | 0.2411 | |
| SRP219564 | GAS8 | 2622 | RNAseq | -0.5838 | 0.0371 | |
| TCGA | GAS8 | 2622 | RNAseq | -0.1134 | 0.0964 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GAS8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GAS8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GAS8 | 2622 | 4 | 3 | 23 | |
| GSE20123 | GAS8 | 2622 | 4 | 3 | 23 | |
| GSE43470 | GAS8 | 2622 | 1 | 13 | 29 | |
| GSE46452 | GAS8 | 2622 | 38 | 1 | 20 | |
| GSE47630 | GAS8 | 2622 | 11 | 9 | 20 | |
| GSE54993 | GAS8 | 2622 | 3 | 4 | 63 | |
| GSE54994 | GAS8 | 2622 | 9 | 11 | 33 | |
| GSE60625 | GAS8 | 2622 | 4 | 0 | 7 | |
| GSE74703 | GAS8 | 2622 | 1 | 9 | 26 | |
| GSE74704 | GAS8 | 2622 | 3 | 1 | 16 | |
| TCGA | GAS8 | 2622 | 26 | 15 | 55 |
Total number of gains: 104; Total number of losses: 69; Total Number of normals: 315.
Somatic mutations of GAS8:
Generating mutation plots.
Highly correlated genes for GAS8:
Showing top 20/1160 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GAS8 | CYP2A6 | 0.695013 | 6 | 0 | 6 |
| GAS8 | CACNG6 | 0.683858 | 3 | 0 | 3 |
| GAS8 | SNORA68 | 0.682853 | 4 | 0 | 4 |
| GAS8 | C12orf74 | 0.677807 | 3 | 0 | 3 |
| GAS8 | B3GAT2 | 0.671749 | 3 | 0 | 3 |
| GAS8 | ANKRD18B | 0.670443 | 4 | 0 | 3 |
| GAS8 | TMEM139 | 0.666086 | 3 | 0 | 3 |
| GAS8 | GPR15 | 0.657825 | 7 | 0 | 5 |
| GAS8 | CACFD1 | 0.655701 | 7 | 0 | 7 |
| GAS8 | LRRC29 | 0.654362 | 3 | 0 | 3 |
| GAS8 | CAPNS2 | 0.654196 | 5 | 0 | 5 |
| GAS8 | FAM95B1 | 0.652023 | 4 | 0 | 3 |
| GAS8 | MVK | 0.65018 | 10 | 0 | 8 |
| GAS8 | AGFG2 | 0.646923 | 9 | 0 | 8 |
| GAS8 | TYSND1 | 0.646797 | 4 | 0 | 4 |
| GAS8 | NAV2-AS5 | 0.646542 | 3 | 0 | 3 |
| GAS8 | EVPL | 0.642894 | 10 | 0 | 10 |
| GAS8 | CNTF | 0.640699 | 3 | 0 | 3 |
| GAS8 | CD5 | 0.640645 | 7 | 0 | 7 |
| GAS8 | CYP2C19 | 0.63995 | 9 | 0 | 8 |
For details and further investigation, click here
