| Full name: chromosome 12 open reading frame 74 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q22 | ||
| Entrez ID: 338809 | HGNC ID: HGNC:27887 | Ensembl Gene: ENSG00000214215 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of C12orf74:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | C12orf74 | 338809 | 1556514_at | -0.2437 | 0.2311 | |
| GSE26886 | C12orf74 | 338809 | 1556514_at | 0.0419 | 0.7035 | |
| GSE45670 | C12orf74 | 338809 | 1556514_at | -0.0154 | 0.8742 | |
| GSE63941 | C12orf74 | 338809 | 1556514_at | 0.0661 | 0.6296 | |
| GSE77861 | C12orf74 | 338809 | 1556514_at | -0.2053 | 0.0291 | |
| GSE97050 | C12orf74 | 338809 | A_24_P838483 | 0.0451 | 0.8410 | |
| TCGA | C12orf74 | 338809 | RNAseq | -1.5646 | 0.0392 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by C12orf74 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of C12orf74:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | C12orf74 | 338809 | 3 | 2 | 25 | |
| GSE20123 | C12orf74 | 338809 | 3 | 2 | 25 | |
| GSE43470 | C12orf74 | 338809 | 3 | 0 | 40 | |
| GSE46452 | C12orf74 | 338809 | 9 | 1 | 49 | |
| GSE47630 | C12orf74 | 338809 | 10 | 1 | 29 | |
| GSE54993 | C12orf74 | 338809 | 0 | 6 | 64 | |
| GSE54994 | C12orf74 | 338809 | 6 | 1 | 46 | |
| GSE60625 | C12orf74 | 338809 | 0 | 0 | 11 | |
| GSE74703 | C12orf74 | 338809 | 3 | 0 | 33 | |
| GSE74704 | C12orf74 | 338809 | 1 | 2 | 17 | |
| TCGA | C12orf74 | 338809 | 17 | 11 | 68 |
Total number of gains: 55; Total number of losses: 26; Total Number of normals: 407.
Somatic mutations of C12orf74:
Generating mutation plots.
Highly correlated genes for C12orf74:
Showing top 20/183 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| C12orf74 | ANKRD22 | 0.767577 | 3 | 0 | 3 |
| C12orf74 | NMU | 0.764197 | 3 | 0 | 3 |
| C12orf74 | GALNT12 | 0.758546 | 3 | 0 | 3 |
| C12orf74 | ZNF823 | 0.756955 | 3 | 0 | 3 |
| C12orf74 | TTC9 | 0.749024 | 3 | 0 | 3 |
| C12orf74 | CAST | 0.747434 | 3 | 0 | 3 |
| C12orf74 | TMEM9B | 0.737115 | 3 | 0 | 3 |
| C12orf74 | RAB11A | 0.734445 | 3 | 0 | 3 |
| C12orf74 | SOCS6 | 0.732099 | 3 | 0 | 3 |
| C12orf74 | DNASE1L3 | 0.730179 | 3 | 0 | 3 |
| C12orf74 | SASH1 | 0.721817 | 3 | 0 | 3 |
| C12orf74 | THSD4 | 0.717699 | 3 | 0 | 3 |
| C12orf74 | PLEKHA7 | 0.717502 | 3 | 0 | 3 |
| C12orf74 | SIM2 | 0.716847 | 3 | 0 | 3 |
| C12orf74 | MGST2 | 0.714804 | 3 | 0 | 3 |
| C12orf74 | SLC16A9 | 0.713268 | 3 | 0 | 3 |
| C12orf74 | CNPPD1 | 0.710822 | 3 | 0 | 3 |
| C12orf74 | DENND2C | 0.709452 | 3 | 0 | 3 |
| C12orf74 | C18orf25 | 0.709266 | 3 | 0 | 3 |
| C12orf74 | ABLIM1 | 0.709229 | 3 | 0 | 3 |
For details and further investigation, click here
