| Full name: Kruppel like factor 2 | Alias Symbol: LKLF | ||
| Type: protein-coding gene | Cytoband: 19p13.11 | ||
| Entrez ID: 10365 | HGNC ID: HGNC:6347 | Ensembl Gene: ENSG00000127528 | OMIM ID: 602016 |
| Drug and gene relationship at DGIdb | |||
KLF2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04068 | FoxO signaling pathway |
Expression of KLF2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLF2 | 10365 | 219371_s_at | -1.3607 | 0.2727 | |
| GSE20347 | KLF2 | 10365 | 219371_s_at | -0.6543 | 0.0014 | |
| GSE23400 | KLF2 | 10365 | 219371_s_at | -0.7053 | 0.0000 | |
| GSE26886 | KLF2 | 10365 | 219371_s_at | 0.3118 | 0.1464 | |
| GSE29001 | KLF2 | 10365 | 219371_s_at | -0.7388 | 0.0135 | |
| GSE38129 | KLF2 | 10365 | 219371_s_at | -1.2297 | 0.0001 | |
| GSE45670 | KLF2 | 10365 | 219371_s_at | -1.8096 | 0.0000 | |
| GSE53622 | KLF2 | 10365 | 56562 | -1.2610 | 0.0000 | |
| GSE53624 | KLF2 | 10365 | 56562 | -1.0874 | 0.0000 | |
| GSE63941 | KLF2 | 10365 | 219371_s_at | -1.2339 | 0.0072 | |
| GSE77861 | KLF2 | 10365 | 219371_s_at | 0.3698 | 0.3088 | |
| GSE97050 | KLF2 | 10365 | A_23_P119196 | -0.8202 | 0.1936 | |
| SRP007169 | KLF2 | 10365 | RNAseq | -0.8354 | 0.1081 | |
| SRP064894 | KLF2 | 10365 | RNAseq | -0.2755 | 0.5310 | |
| SRP133303 | KLF2 | 10365 | RNAseq | -1.1116 | 0.0003 | |
| SRP159526 | KLF2 | 10365 | RNAseq | -0.5767 | 0.1670 | |
| SRP193095 | KLF2 | 10365 | RNAseq | -0.0746 | 0.8640 | |
| SRP219564 | KLF2 | 10365 | RNAseq | -0.1560 | 0.8680 | |
| TCGA | KLF2 | 10365 | RNAseq | -0.7687 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by KLF2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLF2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLF2 | 10365 | 4 | 3 | 23 | |
| GSE20123 | KLF2 | 10365 | 3 | 2 | 25 | |
| GSE43470 | KLF2 | 10365 | 2 | 6 | 35 | |
| GSE46452 | KLF2 | 10365 | 47 | 1 | 11 | |
| GSE47630 | KLF2 | 10365 | 4 | 8 | 28 | |
| GSE54993 | KLF2 | 10365 | 15 | 4 | 51 | |
| GSE54994 | KLF2 | 10365 | 6 | 14 | 33 | |
| GSE60625 | KLF2 | 10365 | 9 | 0 | 2 | |
| GSE74703 | KLF2 | 10365 | 2 | 4 | 30 | |
| GSE74704 | KLF2 | 10365 | 0 | 1 | 19 | |
| TCGA | KLF2 | 10365 | 18 | 9 | 69 |
Total number of gains: 110; Total number of losses: 52; Total Number of normals: 326.
Somatic mutations of KLF2:
Generating mutation plots.
Highly correlated genes for KLF2:
Showing top 20/956 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLF2 | FZD7 | 0.881111 | 3 | 0 | 3 |
| KLF2 | FIBIN | 0.839764 | 4 | 0 | 4 |
| KLF2 | SORCS1 | 0.797584 | 4 | 0 | 4 |
| KLF2 | ARHGAP6 | 0.789635 | 10 | 0 | 10 |
| KLF2 | ABCA8 | 0.787767 | 10 | 0 | 10 |
| KLF2 | XKR4 | 0.782187 | 5 | 0 | 5 |
| KLF2 | C1QTNF7 | 0.777704 | 5 | 0 | 5 |
| KLF2 | GBA2 | 0.773977 | 3 | 0 | 3 |
| KLF2 | ASPA | 0.766539 | 10 | 0 | 10 |
| KLF2 | APOB | 0.766449 | 3 | 0 | 3 |
| KLF2 | GPIHBP1 | 0.765897 | 3 | 0 | 3 |
| KLF2 | ITIH5 | 0.763582 | 9 | 0 | 9 |
| KLF2 | FXYD1 | 0.759057 | 7 | 0 | 7 |
| KLF2 | MRVI1 | 0.755027 | 7 | 0 | 7 |
| KLF2 | NEGR1 | 0.750825 | 6 | 0 | 6 |
| KLF2 | RCAN2 | 0.750169 | 12 | 0 | 11 |
| KLF2 | C20orf194 | 0.74895 | 3 | 0 | 3 |
| KLF2 | EDNRB | 0.748476 | 8 | 0 | 8 |
| KLF2 | CXCL12 | 0.748065 | 11 | 0 | 10 |
| KLF2 | CHRDL1 | 0.747833 | 8 | 0 | 7 |
For details and further investigation, click here
