| Full name: protein phosphatase 1 regulatory subunit 15A | Alias Symbol: GADD34 | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 23645 | HGNC ID: HGNC:14375 | Ensembl Gene: ENSG00000087074 | OMIM ID: 611048 |
| Drug and gene relationship at DGIdb | |||
Expression of PPP1R15A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP1R15A | 23645 | 37028_at | -0.4292 | 0.7188 | |
| GSE20347 | PPP1R15A | 23645 | 37028_at | -0.2218 | 0.3802 | |
| GSE23400 | PPP1R15A | 23645 | 37028_at | -0.4008 | 0.0000 | |
| GSE26886 | PPP1R15A | 23645 | 37028_at | -0.5143 | 0.0880 | |
| GSE29001 | PPP1R15A | 23645 | 37028_at | -0.3674 | 0.0773 | |
| GSE38129 | PPP1R15A | 23645 | 37028_at | -0.3077 | 0.1990 | |
| GSE45670 | PPP1R15A | 23645 | 37028_at | -0.1133 | 0.6983 | |
| GSE53622 | PPP1R15A | 23645 | 103722 | -0.3427 | 0.0109 | |
| GSE53624 | PPP1R15A | 23645 | 103722 | -0.3003 | 0.0018 | |
| GSE63941 | PPP1R15A | 23645 | 37028_at | 0.6853 | 0.3894 | |
| GSE77861 | PPP1R15A | 23645 | 37028_at | 0.1015 | 0.7788 | |
| GSE97050 | PPP1R15A | 23645 | A_23_P90172 | -0.6926 | 0.2302 | |
| SRP007169 | PPP1R15A | 23645 | RNAseq | -1.8383 | 0.0001 | |
| SRP008496 | PPP1R15A | 23645 | RNAseq | -1.5389 | 0.0000 | |
| SRP064894 | PPP1R15A | 23645 | RNAseq | -0.6589 | 0.0008 | |
| SRP133303 | PPP1R15A | 23645 | RNAseq | -0.4541 | 0.1651 | |
| SRP159526 | PPP1R15A | 23645 | RNAseq | -0.9789 | 0.0004 | |
| SRP193095 | PPP1R15A | 23645 | RNAseq | -0.0927 | 0.7098 | |
| SRP219564 | PPP1R15A | 23645 | RNAseq | -0.1420 | 0.8074 | |
| TCGA | PPP1R15A | 23645 | RNAseq | -0.0202 | 0.8176 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PPP1R15A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPP1R15A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP1R15A | 23645 | 4 | 4 | 22 | |
| GSE20123 | PPP1R15A | 23645 | 4 | 3 | 23 | |
| GSE43470 | PPP1R15A | 23645 | 4 | 10 | 29 | |
| GSE46452 | PPP1R15A | 23645 | 45 | 1 | 13 | |
| GSE47630 | PPP1R15A | 23645 | 9 | 6 | 25 | |
| GSE54993 | PPP1R15A | 23645 | 17 | 4 | 49 | |
| GSE54994 | PPP1R15A | 23645 | 4 | 14 | 35 | |
| GSE60625 | PPP1R15A | 23645 | 9 | 0 | 2 | |
| GSE74703 | PPP1R15A | 23645 | 4 | 7 | 25 | |
| GSE74704 | PPP1R15A | 23645 | 4 | 1 | 15 | |
| TCGA | PPP1R15A | 23645 | 14 | 18 | 64 |
Total number of gains: 118; Total number of losses: 68; Total Number of normals: 302.
Somatic mutations of PPP1R15A:
Generating mutation plots.
Highly correlated genes for PPP1R15A:
Showing top 20/228 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP1R15A | AHSP | 0.772246 | 3 | 0 | 3 |
| PPP1R15A | RFX2 | 0.746353 | 3 | 0 | 3 |
| PPP1R15A | LGI2 | 0.733313 | 3 | 0 | 3 |
| PPP1R15A | GBA2 | 0.730801 | 3 | 0 | 3 |
| PPP1R15A | MAPRE3 | 0.727041 | 3 | 0 | 3 |
| PPP1R15A | DVL1 | 0.717466 | 3 | 0 | 3 |
| PPP1R15A | GTPBP1 | 0.71731 | 3 | 0 | 3 |
| PPP1R15A | CBL | 0.716964 | 3 | 0 | 3 |
| PPP1R15A | NKX6-1 | 0.706473 | 4 | 0 | 3 |
| PPP1R15A | ATN1 | 0.705383 | 3 | 0 | 3 |
| PPP1R15A | C9orf47 | 0.701311 | 4 | 0 | 3 |
| PPP1R15A | SCAMP4 | 0.697768 | 3 | 0 | 3 |
| PPP1R15A | TP53BP2 | 0.694688 | 3 | 0 | 3 |
| PPP1R15A | ARIH2 | 0.691508 | 3 | 0 | 3 |
| PPP1R15A | CLDN18 | 0.68939 | 3 | 0 | 3 |
| PPP1R15A | SLC10A2 | 0.689341 | 3 | 0 | 3 |
| PPP1R15A | KLC1 | 0.678933 | 4 | 0 | 3 |
| PPP1R15A | CREB5 | 0.67803 | 3 | 0 | 3 |
| PPP1R15A | VAMP2 | 0.677347 | 5 | 0 | 4 |
| PPP1R15A | KCNC4 | 0.677288 | 3 | 0 | 3 |
For details and further investigation, click here
