| Full name: interleukin 1 receptor antagonist | Alias Symbol: IL1RA|ICIL-1RA|IL1F3|IRAP|IL-1RN|MGC10430 | ||
| Type: protein-coding gene | Cytoband: 2q14.1 | ||
| Entrez ID: 3557 | HGNC ID: HGNC:6000 | Ensembl Gene: ENSG00000136689 | OMIM ID: 147679 |
| Drug and gene relationship at DGIdb | |||
Expression of IL1RN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL1RN | 3557 | 212657_s_at | -2.1545 | 0.2189 | |
| GSE20347 | IL1RN | 3557 | 212657_s_at | -3.0859 | 0.0000 | |
| GSE23400 | IL1RN | 3557 | 212657_s_at | -2.5876 | 0.0000 | |
| GSE26886 | IL1RN | 3557 | 212657_s_at | -5.2636 | 0.0000 | |
| GSE29001 | IL1RN | 3557 | 212657_s_at | -3.0103 | 0.0000 | |
| GSE38129 | IL1RN | 3557 | 212657_s_at | -1.9709 | 0.0109 | |
| GSE45670 | IL1RN | 3557 | 212657_s_at | -0.7376 | 0.0365 | |
| GSE53622 | IL1RN | 3557 | 71437 | -2.2311 | 0.0000 | |
| GSE53624 | IL1RN | 3557 | 71437 | -2.9954 | 0.0000 | |
| GSE63941 | IL1RN | 3557 | 212657_s_at | 2.5575 | 0.1424 | |
| GSE77861 | IL1RN | 3557 | 212657_s_at | -1.7090 | 0.0060 | |
| GSE97050 | IL1RN | 3557 | A_33_P3246829 | 0.2888 | 0.7879 | |
| SRP007169 | IL1RN | 3557 | RNAseq | -5.6669 | 0.0000 | |
| SRP008496 | IL1RN | 3557 | RNAseq | -5.6836 | 0.0000 | |
| SRP064894 | IL1RN | 3557 | RNAseq | -4.2283 | 0.0000 | |
| SRP133303 | IL1RN | 3557 | RNAseq | -3.4622 | 0.0000 | |
| SRP159526 | IL1RN | 3557 | RNAseq | -5.3044 | 0.0000 | |
| SRP193095 | IL1RN | 3557 | RNAseq | -3.5259 | 0.0000 | |
| SRP219564 | IL1RN | 3557 | RNAseq | -3.4525 | 0.0034 | |
| TCGA | IL1RN | 3557 | RNAseq | 0.3007 | 0.1191 |
Upregulated datasets: 0; Downregulated datasets: 15.
Survival by IL1RN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL1RN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL1RN | 3557 | 7 | 2 | 21 | |
| GSE20123 | IL1RN | 3557 | 7 | 2 | 21 | |
| GSE43470 | IL1RN | 3557 | 3 | 1 | 39 | |
| GSE46452 | IL1RN | 3557 | 1 | 4 | 54 | |
| GSE47630 | IL1RN | 3557 | 7 | 0 | 33 | |
| GSE54993 | IL1RN | 3557 | 0 | 6 | 64 | |
| GSE54994 | IL1RN | 3557 | 10 | 2 | 41 | |
| GSE60625 | IL1RN | 3557 | 0 | 3 | 8 | |
| GSE74703 | IL1RN | 3557 | 3 | 1 | 32 | |
| GSE74704 | IL1RN | 3557 | 3 | 2 | 15 | |
| TCGA | IL1RN | 3557 | 31 | 6 | 59 |
Total number of gains: 72; Total number of losses: 29; Total Number of normals: 387.
Somatic mutations of IL1RN:
Generating mutation plots.
Highly correlated genes for IL1RN:
Showing top 20/1269 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL1RN | CSTB | 0.880436 | 12 | 0 | 12 |
| IL1RN | EMP1 | 0.876346 | 11 | 0 | 11 |
| IL1RN | GBP6 | 0.874557 | 4 | 0 | 4 |
| IL1RN | C5orf66-AS1 | 0.86858 | 6 | 0 | 6 |
| IL1RN | CRCT1 | 0.868514 | 12 | 0 | 12 |
| IL1RN | RAB11A | 0.867235 | 10 | 0 | 10 |
| IL1RN | EVPL | 0.863147 | 12 | 0 | 12 |
| IL1RN | CNFN | 0.856601 | 8 | 0 | 8 |
| IL1RN | SCEL | 0.854202 | 13 | 0 | 12 |
| IL1RN | PRSS27 | 0.853274 | 8 | 0 | 8 |
| IL1RN | NCCRP1 | 0.8525 | 4 | 0 | 4 |
| IL1RN | TMPRSS11E | 0.851357 | 12 | 0 | 11 |
| IL1RN | PPL | 0.850242 | 13 | 0 | 13 |
| IL1RN | CLIC3 | 0.849884 | 10 | 0 | 10 |
| IL1RN | CAPN14 | 0.848693 | 7 | 0 | 7 |
| IL1RN | CYSRT1 | 0.84703 | 7 | 0 | 6 |
| IL1RN | SMIM5 | 0.846157 | 6 | 0 | 6 |
| IL1RN | CLCA4 | 0.845197 | 13 | 0 | 13 |
| IL1RN | CRNN | 0.843834 | 12 | 0 | 12 |
| IL1RN | SASH1 | 0.843807 | 10 | 0 | 10 |
For details and further investigation, click here
