| Full name: GTP cyclohydrolase 1 | Alias Symbol: GTPCH1|DYT5a | ||
| Type: protein-coding gene | Cytoband: 14q22.2 | ||
| Entrez ID: 2643 | HGNC ID: HGNC:4193 | Ensembl Gene: ENSG00000131979 | OMIM ID: 600225 |
| Drug and gene relationship at DGIdb | |||
Expression of GCH1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GCH1 | 2643 | 204224_s_at | 0.1074 | 0.8980 | |
| GSE20347 | GCH1 | 2643 | 204224_s_at | -0.1093 | 0.7368 | |
| GSE23400 | GCH1 | 2643 | 204224_s_at | 0.1186 | 0.5151 | |
| GSE26886 | GCH1 | 2643 | 204224_s_at | -1.6792 | 0.0005 | |
| GSE29001 | GCH1 | 2643 | 204224_s_at | -0.0917 | 0.7372 | |
| GSE38129 | GCH1 | 2643 | 204224_s_at | 0.0301 | 0.9271 | |
| GSE45670 | GCH1 | 2643 | 204224_s_at | 0.3324 | 0.1871 | |
| GSE53622 | GCH1 | 2643 | 108471 | 0.0854 | 0.5501 | |
| GSE53624 | GCH1 | 2643 | 108471 | -0.2604 | 0.0058 | |
| GSE63941 | GCH1 | 2643 | 204224_s_at | 1.0135 | 0.1512 | |
| GSE77861 | GCH1 | 2643 | 204224_s_at | -0.4747 | 0.2176 | |
| GSE97050 | GCH1 | 2643 | A_33_P3311439 | 0.3584 | 0.2583 | |
| SRP007169 | GCH1 | 2643 | RNAseq | -1.3425 | 0.0058 | |
| SRP008496 | GCH1 | 2643 | RNAseq | -0.9473 | 0.0015 | |
| SRP064894 | GCH1 | 2643 | RNAseq | -0.0942 | 0.6755 | |
| SRP133303 | GCH1 | 2643 | RNAseq | 0.2461 | 0.3477 | |
| SRP159526 | GCH1 | 2643 | RNAseq | -0.1581 | 0.7549 | |
| SRP193095 | GCH1 | 2643 | RNAseq | -0.2567 | 0.1157 | |
| SRP219564 | GCH1 | 2643 | RNAseq | 0.2919 | 0.6214 | |
| TCGA | GCH1 | 2643 | RNAseq | 0.1080 | 0.2188 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by GCH1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GCH1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GCH1 | 2643 | 8 | 3 | 19 | |
| GSE20123 | GCH1 | 2643 | 8 | 3 | 19 | |
| GSE43470 | GCH1 | 2643 | 9 | 1 | 33 | |
| GSE46452 | GCH1 | 2643 | 16 | 3 | 40 | |
| GSE47630 | GCH1 | 2643 | 11 | 10 | 19 | |
| GSE54993 | GCH1 | 2643 | 3 | 8 | 59 | |
| GSE54994 | GCH1 | 2643 | 19 | 4 | 30 | |
| GSE60625 | GCH1 | 2643 | 0 | 2 | 9 | |
| GSE74703 | GCH1 | 2643 | 8 | 1 | 27 | |
| GSE74704 | GCH1 | 2643 | 3 | 2 | 15 | |
| TCGA | GCH1 | 2643 | 33 | 13 | 50 |
Total number of gains: 118; Total number of losses: 50; Total Number of normals: 320.
Somatic mutations of GCH1:
Generating mutation plots.
Highly correlated genes for GCH1:
Showing top 20/48 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GCH1 | CC2D1B | 0.740274 | 3 | 0 | 3 |
| GCH1 | SHOC2 | 0.709247 | 4 | 0 | 4 |
| GCH1 | SUDS3 | 0.688447 | 3 | 0 | 3 |
| GCH1 | MCM9 | 0.66631 | 3 | 0 | 3 |
| GCH1 | SH2D1B | 0.660725 | 3 | 0 | 3 |
| GCH1 | FARP2 | 0.648192 | 3 | 0 | 3 |
| GCH1 | HES2 | 0.641703 | 4 | 0 | 3 |
| GCH1 | ALKBH2 | 0.637755 | 4 | 0 | 3 |
| GCH1 | ZNF501 | 0.635696 | 4 | 0 | 4 |
| GCH1 | CACUL1 | 0.625102 | 3 | 0 | 3 |
| GCH1 | YIPF1 | 0.615871 | 6 | 0 | 4 |
| GCH1 | DSPP | 0.609122 | 4 | 0 | 3 |
| GCH1 | HCAR3 | 0.604247 | 4 | 0 | 3 |
| GCH1 | SIX2 | 0.602117 | 3 | 0 | 3 |
| GCH1 | BCAP31 | 0.589753 | 4 | 0 | 3 |
| GCH1 | CCDC62 | 0.588893 | 4 | 0 | 3 |
| GCH1 | MYCL | 0.586668 | 4 | 0 | 3 |
| GCH1 | UPF2 | 0.586559 | 3 | 0 | 3 |
| GCH1 | GPAM | 0.585339 | 3 | 0 | 3 |
| GCH1 | ABT1 | 0.583605 | 4 | 0 | 3 |
For details and further investigation, click here
