| Full name: glucokinase | Alias Symbol: HK4 | ||
| Type: protein-coding gene | Cytoband: 7p13 | ||
| Entrez ID: 2645 | HGNC ID: HGNC:4195 | Ensembl Gene: ENSG00000106633 | OMIM ID: 138079 |
| Drug and gene relationship at DGIdb | |||
GCK involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04910 | Insulin signaling pathway | |
| hsa04917 | Prolactin signaling pathway | |
| hsa04930 | Type II diabetes mellitus | |
| hsa04950 | Maturity onset diabetes of the young |
Expression of GCK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GCK | 2645 | 211167_s_at | -0.1370 | 0.8307 | |
| GSE20347 | GCK | 2645 | 211167_s_at | -0.0653 | 0.4276 | |
| GSE23400 | GCK | 2645 | 211167_s_at | -0.1554 | 0.0000 | |
| GSE26886 | GCK | 2645 | 211167_s_at | 0.1453 | 0.5485 | |
| GSE29001 | GCK | 2645 | 211167_s_at | -0.1012 | 0.5572 | |
| GSE38129 | GCK | 2645 | 211167_s_at | -0.1135 | 0.2658 | |
| GSE45670 | GCK | 2645 | 211167_s_at | -0.1131 | 0.1694 | |
| GSE53622 | GCK | 2645 | 67944 | 0.0154 | 0.8584 | |
| GSE53624 | GCK | 2645 | 67944 | 0.1911 | 0.0537 | |
| GSE63941 | GCK | 2645 | 211167_s_at | -0.1694 | 0.2229 | |
| GSE77861 | GCK | 2645 | 211167_s_at | -0.1680 | 0.0701 | |
| GSE97050 | GCK | 2645 | A_33_P3342260 | -0.0210 | 0.9396 | |
| SRP133303 | GCK | 2645 | RNAseq | -0.2076 | 0.4246 | |
| SRP219564 | GCK | 2645 | RNAseq | -0.4635 | 0.3392 | |
| TCGA | GCK | 2645 | RNAseq | -0.3786 | 0.4461 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GCK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GCK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GCK | 2645 | 14 | 0 | 16 | |
| GSE20123 | GCK | 2645 | 13 | 0 | 17 | |
| GSE43470 | GCK | 2645 | 4 | 0 | 39 | |
| GSE46452 | GCK | 2645 | 11 | 1 | 47 | |
| GSE47630 | GCK | 2645 | 8 | 1 | 31 | |
| GSE54993 | GCK | 2645 | 0 | 8 | 62 | |
| GSE54994 | GCK | 2645 | 17 | 3 | 33 | |
| GSE60625 | GCK | 2645 | 0 | 0 | 11 | |
| GSE74703 | GCK | 2645 | 4 | 0 | 32 | |
| GSE74704 | GCK | 2645 | 7 | 0 | 13 | |
| TCGA | GCK | 2645 | 51 | 7 | 38 |
Total number of gains: 129; Total number of losses: 20; Total Number of normals: 339.
Somatic mutations of GCK:
Generating mutation plots.
Highly correlated genes for GCK:
Showing top 20/497 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GCK | KLHL35 | 0.711039 | 3 | 0 | 3 |
| GCK | TERT | 0.684207 | 4 | 0 | 4 |
| GCK | SCNN1G | 0.679576 | 4 | 0 | 4 |
| GCK | BRINP2 | 0.676376 | 4 | 0 | 4 |
| GCK | OR11A1 | 0.67422 | 5 | 0 | 5 |
| GCK | CAPN10 | 0.667862 | 3 | 0 | 3 |
| GCK | FOXH1 | 0.654144 | 4 | 0 | 4 |
| GCK | TMPRSS5 | 0.653734 | 3 | 0 | 3 |
| GCK | NEU3 | 0.649239 | 3 | 0 | 3 |
| GCK | CRYAA | 0.647361 | 4 | 0 | 3 |
| GCK | GPAT2 | 0.647191 | 4 | 0 | 3 |
| GCK | KCNQ2 | 0.646882 | 5 | 0 | 4 |
| GCK | CHRNA6 | 0.645449 | 3 | 0 | 3 |
| GCK | BTNL3 | 0.642107 | 4 | 0 | 4 |
| GCK | SYT13 | 0.641614 | 4 | 0 | 4 |
| GCK | ODF1 | 0.640551 | 4 | 0 | 4 |
| GCK | MTAP | 0.638118 | 4 | 0 | 4 |
| GCK | SLC6A5 | 0.637748 | 3 | 0 | 3 |
| GCK | CDAN1 | 0.636977 | 3 | 0 | 3 |
| GCK | SCGB1D1 | 0.636905 | 3 | 0 | 3 |
For details and further investigation, click here
