| Full name: ER degradation enhancing alpha-mannosidase like protein 2 | Alias Symbol: FLJ10783|bA4204.1 | ||
| Type: protein-coding gene | Cytoband: 20q11.22 | ||
| Entrez ID: 55741 | HGNC ID: HGNC:15877 | Ensembl Gene: ENSG00000088298 | OMIM ID: 610302 |
| Drug and gene relationship at DGIdb | |||
Expression of EDEM2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EDEM2 | 55741 | 218282_at | 0.9298 | 0.0336 | |
| GSE20347 | EDEM2 | 55741 | 218282_at | 0.4656 | 0.0015 | |
| GSE23400 | EDEM2 | 55741 | 218282_at | 0.3009 | 0.0000 | |
| GSE26886 | EDEM2 | 55741 | 218282_at | 0.2006 | 0.3092 | |
| GSE29001 | EDEM2 | 55741 | 218282_at | 0.5548 | 0.0297 | |
| GSE38129 | EDEM2 | 55741 | 218282_at | 0.5649 | 0.0000 | |
| GSE45670 | EDEM2 | 55741 | 218282_at | 0.4946 | 0.0021 | |
| GSE53622 | EDEM2 | 55741 | 25630 | 0.8552 | 0.0000 | |
| GSE53624 | EDEM2 | 55741 | 25630 | 0.7311 | 0.0000 | |
| GSE63941 | EDEM2 | 55741 | 218282_at | 0.0231 | 0.9726 | |
| GSE77861 | EDEM2 | 55741 | 218282_at | 0.3750 | 0.3146 | |
| GSE97050 | EDEM2 | 55741 | A_24_P627306 | 0.9276 | 0.1239 | |
| SRP007169 | EDEM2 | 55741 | RNAseq | 0.5182 | 0.3354 | |
| SRP008496 | EDEM2 | 55741 | RNAseq | 0.5932 | 0.1027 | |
| SRP064894 | EDEM2 | 55741 | RNAseq | 1.1896 | 0.0000 | |
| SRP133303 | EDEM2 | 55741 | RNAseq | 0.6718 | 0.0000 | |
| SRP159526 | EDEM2 | 55741 | RNAseq | 0.5767 | 0.0389 | |
| SRP193095 | EDEM2 | 55741 | RNAseq | 0.2313 | 0.1344 | |
| SRP219564 | EDEM2 | 55741 | RNAseq | 1.2021 | 0.0004 | |
| TCGA | EDEM2 | 55741 | RNAseq | 0.1366 | 0.0164 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by EDEM2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EDEM2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EDEM2 | 55741 | 16 | 0 | 14 | |
| GSE20123 | EDEM2 | 55741 | 16 | 0 | 14 | |
| GSE43470 | EDEM2 | 55741 | 13 | 0 | 30 | |
| GSE46452 | EDEM2 | 55741 | 29 | 0 | 30 | |
| GSE47630 | EDEM2 | 55741 | 25 | 0 | 15 | |
| GSE54993 | EDEM2 | 55741 | 0 | 17 | 53 | |
| GSE54994 | EDEM2 | 55741 | 25 | 0 | 28 | |
| GSE60625 | EDEM2 | 55741 | 0 | 0 | 11 | |
| GSE74703 | EDEM2 | 55741 | 11 | 0 | 25 | |
| GSE74704 | EDEM2 | 55741 | 11 | 0 | 9 | |
| TCGA | EDEM2 | 55741 | 49 | 3 | 44 |
Total number of gains: 195; Total number of losses: 20; Total Number of normals: 273.
Somatic mutations of EDEM2:
Generating mutation plots.
Highly correlated genes for EDEM2:
Showing top 20/1260 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EDEM2 | NFS1 | 0.718044 | 10 | 0 | 9 |
| EDEM2 | NLN | 0.715128 | 3 | 0 | 3 |
| EDEM2 | METTL23 | 0.709452 | 4 | 0 | 3 |
| EDEM2 | TPX2 | 0.7051 | 11 | 0 | 10 |
| EDEM2 | TTYH3 | 0.701534 | 6 | 0 | 6 |
| EDEM2 | C19orf48 | 0.70101 | 3 | 0 | 3 |
| EDEM2 | TANGO2 | 0.697924 | 4 | 0 | 4 |
| EDEM2 | PSMA7 | 0.697894 | 8 | 0 | 7 |
| EDEM2 | KIF3B | 0.696408 | 10 | 0 | 9 |
| EDEM2 | GCSH | 0.693858 | 3 | 0 | 3 |
| EDEM2 | CSE1L | 0.693603 | 9 | 0 | 7 |
| EDEM2 | NUDT1 | 0.693046 | 9 | 0 | 9 |
| EDEM2 | NOP56 | 0.684811 | 3 | 0 | 3 |
| EDEM2 | CKS1B | 0.682438 | 10 | 0 | 9 |
| EDEM2 | NELFCD | 0.680983 | 9 | 0 | 8 |
| EDEM2 | PPIL1 | 0.679271 | 4 | 0 | 4 |
| EDEM2 | YDJC | 0.678966 | 4 | 0 | 4 |
| EDEM2 | MYBL2 | 0.678307 | 10 | 0 | 8 |
| EDEM2 | C4orf46 | 0.677859 | 4 | 0 | 4 |
| EDEM2 | RPN2 | 0.672732 | 11 | 0 | 8 |
For details and further investigation, click here
