| Full name: gem nuclear organelle associated protein 4 | Alias Symbol: HHRF-1|DKFZP434B131|p97|DKFZP434D174|HC56|HCAP1 | ||
| Type: protein-coding gene | Cytoband: 17p13.3 | ||
| Entrez ID: 50628 | HGNC ID: HGNC:15717 | Ensembl Gene: ENSG00000179409 | OMIM ID: 606969 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of GEMIN4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GEMIN4 | 50628 | 217099_s_at | 0.4075 | 0.1471 | |
| GSE20347 | GEMIN4 | 50628 | 205527_s_at | 0.4635 | 0.0024 | |
| GSE23400 | GEMIN4 | 50628 | 217099_s_at | 0.1679 | 0.0004 | |
| GSE26886 | GEMIN4 | 50628 | 205527_s_at | 1.1375 | 0.0000 | |
| GSE29001 | GEMIN4 | 50628 | 205527_s_at | 0.4381 | 0.1902 | |
| GSE38129 | GEMIN4 | 50628 | 205527_s_at | 0.5655 | 0.0001 | |
| GSE45670 | GEMIN4 | 50628 | 205527_s_at | 0.2850 | 0.0235 | |
| GSE63941 | GEMIN4 | 50628 | 205527_s_at | 0.5085 | 0.1949 | |
| GSE77861 | GEMIN4 | 50628 | 217099_s_at | 0.3539 | 0.2118 | |
| GSE97050 | GEMIN4 | 50628 | A_23_P66872 | 0.2900 | 0.2316 | |
| SRP007169 | GEMIN4 | 50628 | RNAseq | 0.9673 | 0.0130 | |
| SRP008496 | GEMIN4 | 50628 | RNAseq | 0.7246 | 0.0078 | |
| SRP064894 | GEMIN4 | 50628 | RNAseq | 0.0930 | 0.5539 | |
| SRP133303 | GEMIN4 | 50628 | RNAseq | -0.1493 | 0.4380 | |
| SRP159526 | GEMIN4 | 50628 | RNAseq | 0.0671 | 0.7778 | |
| SRP193095 | GEMIN4 | 50628 | RNAseq | 0.3902 | 0.0025 | |
| SRP219564 | GEMIN4 | 50628 | RNAseq | -0.0522 | 0.8643 | |
| TCGA | GEMIN4 | 50628 | RNAseq | 0.0545 | 0.3411 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by GEMIN4 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GEMIN4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GEMIN4 | 50628 | 5 | 2 | 23 | |
| GSE20123 | GEMIN4 | 50628 | 5 | 3 | 22 | |
| GSE43470 | GEMIN4 | 50628 | 1 | 7 | 35 | |
| GSE46452 | GEMIN4 | 50628 | 34 | 1 | 24 | |
| GSE47630 | GEMIN4 | 50628 | 8 | 1 | 31 | |
| GSE54993 | GEMIN4 | 50628 | 8 | 3 | 59 | |
| GSE54994 | GEMIN4 | 50628 | 7 | 9 | 37 | |
| GSE60625 | GEMIN4 | 50628 | 4 | 0 | 7 | |
| GSE74703 | GEMIN4 | 50628 | 1 | 4 | 31 | |
| GSE74704 | GEMIN4 | 50628 | 3 | 1 | 16 | |
| TCGA | GEMIN4 | 50628 | 19 | 21 | 56 |
Total number of gains: 95; Total number of losses: 52; Total Number of normals: 341.
Somatic mutations of GEMIN4:
Generating mutation plots.
Highly correlated genes for GEMIN4:
Showing top 20/991 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GEMIN4 | SLC30A7 | 0.701596 | 3 | 0 | 3 |
| GEMIN4 | OCIAD2 | 0.697351 | 4 | 0 | 4 |
| GEMIN4 | CYBA | 0.694934 | 3 | 0 | 3 |
| GEMIN4 | NOP2 | 0.681836 | 9 | 0 | 9 |
| GEMIN4 | CLEC11A | 0.673908 | 3 | 0 | 3 |
| GEMIN4 | SHISA2 | 0.673801 | 4 | 0 | 4 |
| GEMIN4 | NOP14 | 0.671354 | 7 | 0 | 7 |
| GEMIN4 | LEMD2 | 0.665526 | 3 | 0 | 3 |
| GEMIN4 | GNL2 | 0.664957 | 4 | 0 | 4 |
| GEMIN4 | ATG2A | 0.66439 | 3 | 0 | 3 |
| GEMIN4 | XPO5 | 0.663341 | 5 | 0 | 5 |
| GEMIN4 | TRIM27 | 0.662533 | 5 | 0 | 5 |
| GEMIN4 | SULT1A2 | 0.662069 | 3 | 0 | 3 |
| GEMIN4 | AGO2 | 0.65958 | 3 | 0 | 3 |
| GEMIN4 | CCDC24 | 0.65852 | 3 | 0 | 3 |
| GEMIN4 | ZDHHC16 | 0.658449 | 4 | 0 | 4 |
| GEMIN4 | SMKR1 | 0.656661 | 3 | 0 | 3 |
| GEMIN4 | IRAK1 | 0.65514 | 6 | 0 | 5 |
| GEMIN4 | SKP2 | 0.649847 | 5 | 0 | 3 |
| GEMIN4 | ERVMER34-1 | 0.649027 | 6 | 0 | 5 |
For details and further investigation, click here
