NOP2

 

Full name: NOP2 nucleolar protein Alias Symbol: NOP120|NSUN1|p120
Type: protein-coding gene Cytoband: 12p13.31
Entrez ID: 4839 HGNC ID: HGNC:7867 Ensembl Gene: ENSG00000111641 OMIM ID: 164031
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of NOP2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NOP2 4839 214427_at 1.1205 0.0389
GSE20347 NOP2 4839 214427_at 0.8051 0.0002
GSE23400 NOP2 4839 214427_at 0.6716 0.0000
GSE26886 NOP2 4839 214427_at 1.3165 0.0000
GSE29001 NOP2 4839 214427_at 0.8095 0.0030
GSE38129 NOP2 4839 214427_at 0.8083 0.0003
GSE45670 NOP2 4839 214427_at 0.8024 0.0036
GSE53622 NOP2 4839 49224 1.2071 0.0000
GSE53624 NOP2 4839 49224 1.1206 0.0000
GSE63941 NOP2 4839 214427_at 1.4657 0.0009
GSE77861 NOP2 4839 214427_at 0.8404 0.0039
GSE97050 NOP2 4839 A_23_P204364 0.8621 0.1657
SRP007169 NOP2 4839 RNAseq 1.7617 0.0004
SRP008496 NOP2 4839 RNAseq 1.7033 0.0000
SRP064894 NOP2 4839 RNAseq 0.5329 0.0037
SRP133303 NOP2 4839 RNAseq 1.0474 0.0000
SRP159526 NOP2 4839 RNAseq 0.9168 0.0070
SRP193095 NOP2 4839 RNAseq 0.8869 0.0000
SRP219564 NOP2 4839 RNAseq 0.9707 0.0177
TCGA NOP2 4839 RNAseq 0.3555 0.0000

Upregulated datasets: 8; Downregulated datasets: 0.  

 

Survival by NOP2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of NOP2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NOP2 4839 9 4 17
GSE20123 NOP2 4839 9 4 17
GSE43470 NOP2 4839 8 3 32
GSE46452 NOP2 4839 10 1 48
GSE47630 NOP2 4839 12 2 26
GSE54993 NOP2 4839 1 10 59
GSE54994 NOP2 4839 10 2 41
GSE60625 NOP2 4839 0 1 10
GSE74703 NOP2 4839 7 2 27
GSE74704 NOP2 4839 5 3 12
TCGA NOP2 4839 40 6 50

Total number of gains: 111; Total number of losses: 38; Total Number of normals: 339.  

 

Somatic mutations of NOP2:

 

Generating mutation plots.

 

Highly correlated genes for NOP2:

 

Showing top 20/2126 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NOP2DKC10.806874303
NOP2UCK20.787559303
NOP2UBE2T0.778928808
NOP2CAD0.76894912012
NOP2DDX39A0.76493812012
NOP2DNAJB110.762308606
NOP2CDCA30.76174212011
NOP2EFTUD20.759766808
NOP2YARS20.75803412012
NOP2MTBP0.754575606
NOP2NCAPD20.75391512012
NOP2DNMT10.75384212012
NOP2RAD51AP10.7525812012
NOP2BLM0.75223312012
NOP2DNAJC20.74826511011
NOP2FAM89A0.746428303
NOP2HEATR10.74596412011
NOP2XPO50.745318808
NOP2ECE20.745307807
NOP2MRPL470.745005808

For details and further investigation, click here