SKP2

 

Full name: S-phase kinase associated protein 2 Alias Symbol: FBXL1|FBL1|p45
Type: protein-coding gene Cytoband: 5p13.2
Entrez ID: 6502 HGNC ID: HGNC:10901 Ensembl Gene: ENSG00000145604 OMIM ID: 601436
Drug and gene relationship at DGIdb
Screen Evidence:

 

SKP2 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle
hsa04150mTOR signaling pathway
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05222Small cell lung cancer

 

Expression of SKP2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SKP2 6502 203625_x_at 1.1230 0.0331
GSE20347 SKP2 6502 203625_x_at 0.5885 0.0005
GSE23400 SKP2 6502 203625_x_at 0.8955 0.0000
GSE26886 SKP2 6502 203625_x_at 0.4016 0.1456
GSE29001 SKP2 6502 203625_x_at 0.6103 0.0773
GSE38129 SKP2 6502 203625_x_at 0.9841 0.0000
GSE45670 SKP2 6502 203625_x_at 0.8249 0.0003
GSE53622 SKP2 6502 102832 1.0213 0.0000
GSE53624 SKP2 6502 102832 1.0257 0.0000
GSE63941 SKP2 6502 203625_x_at 1.6219 0.0045
GSE77861 SKP2 6502 203625_x_at 0.3291 0.4578
GSE97050 SKP2 6502 A_23_P156310 0.7009 0.2043
SRP007169 SKP2 6502 RNAseq 0.8275 0.0238
SRP008496 SKP2 6502 RNAseq 0.7202 0.0329
SRP064894 SKP2 6502 RNAseq 0.1700 0.4432
SRP133303 SKP2 6502 RNAseq 0.3286 0.0412
SRP159526 SKP2 6502 RNAseq 1.2894 0.0123
SRP193095 SKP2 6502 RNAseq 0.2483 0.0766
SRP219564 SKP2 6502 RNAseq 0.0865 0.8563
TCGA SKP2 6502 RNAseq 0.6593 0.0000

Upregulated datasets: 5; Downregulated datasets: 0.  

 

Survival by SKP2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SKP2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SKP2 6502 10 0 20
GSE20123 SKP2 6502 10 0 20
GSE43470 SKP2 6502 17 0 26
GSE46452 SKP2 6502 5 22 32
GSE47630 SKP2 6502 6 12 22
GSE54993 SKP2 6502 5 4 61
GSE54994 SKP2 6502 26 2 25
GSE60625 SKP2 6502 0 0 11
GSE74703 SKP2 6502 13 0 23
GSE74704 SKP2 6502 9 0 11
TCGA SKP2 6502 52 6 38

Total number of gains: 153; Total number of losses: 46; Total Number of normals: 289.  

 

Somatic mutations of SKP2:

 

Generating mutation plots.

 

Highly correlated genes for SKP2:

 

Showing top 20/1523 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SKP2UBA10.772316303
SKP2MMS22L0.763306303
SKP2GORAB0.750537404
SKP2CDC200.746901909
SKP2BCAR10.743374303
SKP2TRIP130.74172213012
SKP2INTS100.734748404
SKP2TPX20.72786811011
SKP2BRIX10.72665912012
SKP2SPNS10.726156303
SKP2TTK0.72490712012
SKP2DHRS130.724205303
SKP2DNA20.72420411011
SKP2DTL0.72209212010
SKP2RACGAP10.71809510010
SKP2LRRC580.718007303
SKP2NUSAP10.71775713011
SKP2NACC10.717661303
SKP2CCT50.71522908
SKP2ORAI10.714385403

For details and further investigation, click here